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Recent advances in deep learning for tomographic reconstructions have shown great potential to create accurate and high quality images with a considerable speed-up. In this work we present a deep neural network that is specifically designed…

Computer Vision and Pattern Recognition · Computer Science 2020-09-07 Andreas Hauptmann , Felix Lucka , Marta Betcke , Nam Huynh , Jonas Adler , Ben Cox , Paul Beard , Sebastien Ourselin , Simon Arridge

The promise of artificial intelligence (AI) to process complex datasets has brought about innovative computing paradigms. While recent developments in quantum-photonic computing have reached significant feats, mimicking our brain's ability…

Optics · Physics 2021-11-23 Vincent R. Daria

Deep learning has been used to improve photoacoustic (PA) image reconstruction. One major challenge is that errors cannot be quantified to validate predictions when ground truth is unknown. Validation is key to quantitative applications,…

Image and Video Processing · Electrical Eng. & Systems 2024-07-04 Ruibo Shang , Geoffrey P. Luke , Matthew O'Donnell

Our aim was to enhance visual quality and quantitative accuracy of dynamic positron emission tomography (PET)uptake images by improved image reconstruction, using sophisticated sparse penalty models that incorporate both 2D spatial+1D…

Computer Vision and Pattern Recognition · Computer Science 2019-06-17 Ida Häggström , Yizun Lin , Si Li , Andrzej Krol , Yuesheng Xu , C. Ross Schmidtlein

We deal with the photoacoustic imaging modality using dielectric nanoparticles as contrast agents. Exciting the heterogeneous tissue, localized in a bounded domain $\Omega$, with an electromagnetic wave, at a given incident frequency,…

Analysis of PDEs · Mathematics 2020-03-09 Ahcene Ghandriche , Mourad Sini

Acousto-optical coherence tomography (AOCT) consists in using random phase jumps on ultrasound and light to achieve a millimeter resolution when imaging thick scattering media. We combined this technique with heterodyne off-axis digital…

Structural microvascular alterations and dysfunction serve as key disease indicators of cancer, diabetes, ischemic stroke, neurodegenerative disorders and many other conditions. In vivo visualization of the microvasculature has…

Biological Physics · Physics 2020-07-02 Xosé Luís Deán-Ben , Justine Robin , Ruiqing Ni , Daniel Razansky

A universal unanswered question in neuroscience and machine learning is whether computers can decode the patterns of the human brain. Multi-Voxels Pattern Analysis (MVPA) is a critical tool for addressing this question. However, there are…

Machine Learning · Statistics 2016-09-06 Muhammad Yousefnezhad , Daoqiang Zhang

Three-dimensional (3D) photoacoustic computed tomography (PACT) is a powerful noninvasive biomedical imaging modality that provides volumetric data for structural and functional assessment \textit{in vivo}. To maximize angular coverage and…

Medical Physics · Physics 2026-03-26 Wanqing Zhang , Hengyue Zhu , Yide Zhang

Photoacoustic computed tomography (PACT), also known as optoacoustic tomography, is an emerging imaging modality that has great potential for a wide range of biomedical imaging applications. In this Note, we derive a hybrid reconstruction…

Analysis of PDEs · Mathematics 2015-06-11 Kun Wang , Mark A. Anastasio

Purpose: Optoacoustic tomography (OAT) is inherently a three-dimensional (3D) inverse problem. However, most studies of OAT image reconstruction still employ two-dimensional (2D) imaging models. One important reason is because 3D image…

Medical Physics · Physics 2013-04-09 Kun Wang , Chao Huang , Yu-Jiun Kao , Cheng-Ying Chou , Alexander A. Oraevsky , Mark A. Anastasio

Acoustic holographic lenses, also known as acoustic holograms, can change the phase of a transmitted wavefront in order to shape and construct complex ultrasound pressure fields, often for focusing the acoustic energy on a target region.…

Photoacoustic tomography (PAT) offers optical contrast, whereas magnetic resonance imaging (MRI) excels in imaging soft tissue and organ anatomy. The fusion of PAT with MRI holds promising application prospects due to their complementary…

Image and Video Processing · Electrical Eng. & Systems 2025-03-20 Yutian Zhong , Jinchuan He , Zhichao Liang , Shuangyang Zhang , Qianjin Feng , Lijun Lu , Li Qi

Photoacoustic imaging (PAI) is a novel hybrid imaging technique that combines the benefits of both optical and acoustic imaging modalities, which provides functional and molecular optical contrasts of deep tissue. Commonly used ultrasound…

Medical Physics · Physics 2025-09-24 Xiyu Chen , Junxiang Cai , Rui Zheng , Tao Wu , Fei Gao

Quantitative photoacoustic tomography is an emerging imaging technique aimed at estimating the distribution of optical parameters inside tissues from photoacoustic images, which are formed by combining optical information and ultrasonic…

Numerical Analysis · Mathematics 2016-06-02 Antti Hannukainen , Nuutti Hyvönen , Helle Majander , Tanja Tarvainen

Objective Positron emission tomography (PET) allows imaging of patho-physiological information as a form of rate constants from a dynamic image. The rate constant image(s) may be affected from noise on the dynamic image. We introduced an…

Medical Physics · Physics 2023-08-10 Nobuyuki Kudomi , Yukito Maeda

During brain tumour resection, localising cancerous tissue and delineating healthy and pathological borders is challenging, even for experienced neurosurgeons and neuroradiologists. Intraoperative imaging is commonly employed for…

3D-Polarized Light Imaging (3D-PLI) reconstructs nerve fibers in histological brain sections by measuring their birefringence. This study investigates another effect caused by the optical anisotropy of brain tissue - diattenuation. Based on…

Medical Physics · Physics 2017-06-13 Miriam Menzel , Julia Reckfort , Daniel Weigand , Hasan Köse , Katrin Amunts , Markus Axer

Photo-acoustic tomography is a newly developed hybrid imaging modality that combines a high-resolution modality with a high-contrast modality. We analyze the reconstruction of diffusion and absorption parameters in an elliptic equation and…

Analysis of PDEs · Mathematics 2015-06-04 Jie Chen , Yang Yang

Non-invasive observation of spatiotemporal neural activity of large neural populations distributed over entire brains is a longstanding goal of neuroscience. We developed a real-time volumetric and multispectral optoacoustic tomography…

Neurons and Cognition · Quantitative Biology 2015-01-13 Gali Sela , Antonella Lauri , X. Luís Deán-Ben , Moritz Kneipp , Vasilis Ntziachristos , Shy Shoham , Gil G. Westmeyer , Daniel Razansky