Related papers: The evolution of the GALactose utilization pathway…
The Milky Way bulge offers a unique opportunity to investigate in detail the role that different processes such as dynamical instabilities, hierarchical merging, and dissipational collapse may have played in the history of the Galaxy…
Cell signaling, gene expression, and metabolism are affected by cell-cell heterogeneity and random changes in the environment. The effects of such fluctuations on cell signaling and gene expression have recently been studied intensively…
Many DNA sequence variants influence phenotypes by altering gene expression. Our understanding of these variants is limited by sample sizes of current studies and by measurements of mRNA rather than protein abundance. We developed a…
In the standard model of structure formation, galaxies form in the centre of dark matter haloes that develop as a result of inhomogeneities in the primordial mass distribution of the Universe. Afterwards, galaxies grow by means of…
In this paper we address the issue of the origin of some observational properties of the galactic globular cluster system. After a preliminary study of some general properties of the main evolutionary processes, we investigate the evolution…
Segregation of populations is a key question in evolution theory. One important aspect is the relation between spatial organization and the population's composition. Here we study a specific example -- sectors in expanding bacterial…
The aim of Galactic Archaeology is to recover the evolutionary history of the Milky Way from its present day kinematical and chemical state. Because stars move away from their birth sites, the current dynamical information alone is not…
The Galform semi-analytic model of galaxy formation is used to explore the mechanisms primarily responsible for the three types of galaxies seen in the local universe: bulge, bulge+disk and disk, identified with the visual morphological…
Various bacterial strains exhibit colonial branching patterns during growth on poor substrates. These patterns reflect bacterial cooperative self-organization and cybernetic processes of communication, regulation and control employed during…
A suite of vast stellar surveys mapping the Milky Way, culminating in the Gaia mission, is revolutionizing the empirical information about the distribution and properties of stars in the Galactic stellar disk. We review and lay out what…
Since the late `60s, various genome evolutionary models have been proposed to predict the evolution of a DNA sequence as the generations pass. Most of these models are based on nucleotides evolution, so they use a mutation matrix of size…
We developed an iterative technique to better characterize stellar populations and the central activity of barred galaxies using evolutionary synthesis codes and OASIS data. The case of NGC5430 is presented here. Our results are reinforcing…
Microbial interactions regulate their spread and survival in competitive environments. It is not clear if the physical parameters of the environment regulate the outcome of these interactions. In this work, we show that the opportunistic…
The identification of sets of co-regulated genes that share a common function is a key question of modern genomics. Bayesian profile regression is a semi-supervised mixture modelling approach that makes use of a response to guide inference…
The outcomes of evolution are determined by which mutations occur and fix. In rapidly adapting microbial populations, this process is particularly hard to predict because lineages with different beneficial mutations often spread…
Chlamydiae are bacteria with an interesting unusual developmental cycle. A single bacterium in its infectious form (elementary body, EB) enters the host cell, where it converts into its dividing form (reticulate body, RB), and divides by…
Bacteria pose unique challenges for genome-wide association studies (GWAS) because of strong structuring into distinct strains and substantial linkage disequilibrium across the genome. While methods developed for human studies can correct…
Phylogenetic methods, traditionally used in biology to trace the evolutionary relationships among species, are emerging as a powerful framework to reconstruct evolutionary processes in galaxies from chemical information. We apply galactic…
Conjugation is the primary mechanism of horizontal gene transfer that spreads antibiotic resistance among bacteria. Although conjugation normally occurs in surface-associated growth (e.g., biofilms), it has been traditionally studied in…
Multistable gene regulatory systems sustain different levels of gene expression under identical external conditions. Such multistability is used to encode phenotypic states in processes including nutrient uptake and persistence in bacteria,…