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Molecular variants of vitamin B12, siderophores and glycans occur. To take up variant forms, bacteria may express an array of receptors. The gut microbe Bacteroides thetaiotaomicron has three different receptors to take up variants of…
Organisms across all domains of life regulate the size of their cells. However, the means by which this is done is poorly understood. We study two abstracted "molecular" models for size regulation: inhibitor dilution and initiator…
We investigate the structural and dynamical properties of the transcriptional regulatory network of the yeast {\it Saccharomyces cerevisiae} and compare it with two unbiased ensembles: one obtained by reshuffling the edges and the other…
We consider a general growth mechanism, which acts at cellular level and above (organs, systems and whole organisms). Using its mathematical representation, the growth equation, we study the growth and division mechanisms of amoeba and…
The history of the formation and evolution of the Milky Way Galaxy is found in the spatial distribution, kinematics, age and chemical abundance distributions of long-lived stars. From this fossil record one can in principle extract the star…
Bulges are of different types, morphologies and kinematics, from pseudo-bulges, close to disk properties (Sersic index, rotation fraction, flatenning), to classical de Vaucouleurs bulges, close to elliptical galaxies. Secular evolution and…
During batch growth on mixtures of two growth-limiting substrates, microbes consume the substrates either sequentially or simultaneously. These growth patterns are manifested in all types of bacteria and yeasts. The ubiquity of these growth…
In this series of lectures I discuss the basic principles and the modelling of the chemical evolution of galaxies. In particular, I present models for the chemical evolution of the Milky Way galaxy and compare them with the available…
Glucose is a primary energy source for cancer cells. Several lines of evidence support the idea that monocarboxylate transporters, such as MCT1, elicit metabolic reprogramming of cancer cells in glucose-poor environments, allowing them to…
Galaxies are not isolated systems; they continuously interact with their surroundings by ejecting gas via stellar feedback and accreting gas from the environment. Understanding the interplay between outflows from the disc and the…
In current $\Lambda$CDM galaxy formation scenarios, at least three physical phenomena could contribute to the mass assembly: monolithic collapse, hierarchical mergers and more quiescent external gas accretion, with secular evolution. The…
We model the evolution of the galactic bulge and of the bulges of a selected sample of external spiral galaxies, via the multiphase multizone evolution model. We address a few questions concerning the role of the bulges within galactic…
Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity…
The Milky Way serves as a template for understanding the formation and evolution of late-type massive disk galaxies since we can obtain detailed chemical and kinematic information for large samples of individual stars. However, the early…
This paper deals with branching processes in varying environment, namely, whose offspring distributions depend on the generations. We provide sufficient conditions for survival or extinction which rely only on the first and second moments…
The mating pathway in \emph{Saccharomyces cerevisiae} is one of the best understood signal transduction pathways in eukaryotes. It transmits the mating signal from plasma membrane into the nucleus through the G-protein coupled receptor and…
How do galaxies form and evolve? This is one of the most puzzling questions in astronomy. Galaxy assembly takes place throughout the entire history of the Universe, but our understanding of it is hampered by the unfortunate fact that we can…
Since stellar populations enhance particular element abundances according to the yields and lifetimes of the stellar progenitors, the chemical evolution of galaxies serves as one of the key tools that allows the tracing of galaxy evolution.…
Globular Cluster (GC) formation seems to be a widespread mode of star formation in extreme starbursts triggered by strong interactions and mergers of massive gas-rich galaxies. We use our detailed chemically consistent evolutionary…
This paper develops simplified mathematical models describing the mutation-selection balance for the asexual and sexual replication pathways in {\it Saccharomyces cerevisiae}. We assume diploid genomes consisting of two chromosomes, and we…