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The Milky Way is the only galaxy for which we can resolve individual stars at all evolutionary phases, from the Galactic center to the outskirt. The last decade, thanks to the advent of near IR detectors and 8 meter class telescopes, has…
Competition between random genetic drift and natural selection plays a central role in evolution: Whereas non-beneficial mutations often prevail in small populations by chance, mutations that sweep through large populations typically confer…
Despite the importance that fluid flow plays in transporting and organizing populations, few laboratory systems exist to systematically investigate the impact of advection on their spatial evolutionary dynamics. To address this problem, we…
We make use of recent estimates for the parameters of the Milky Way's halo globular clusters and study the influence of the galactic bar on the dynamics of these clusters by computing their orbits. We use both an axisymmetric and…
Baker's yeast (Saccharomyces cerevisiae) is a model organism for studying the morphology that emerges at the scale of multi-cell colonies. To look at how morphology develops, we collect a dataset of time-lapse photographs of the growth of…
Drug gradients are believed to play an important role in the evolution of bacteria resistant to antibiotics and tumors resistant to anti-cancer drugs. We use a statistical physics model to study the evolution of a population of malignant…
The colonic mucus layer is a dynamic and complex structure formed by secreted and transmembrane mucins, which are high-molecular-weight and heavily glycosylated proteins. Colonic mucus consists of a loose outer layer and a dense…
The yeast Saccharomyces cerevisiae is one of the best characterized eukaryotic models. The secretory pathway was the first trafficking pathway clearly understood mainly thanks to the work done in the laboratory of Randy Schekman in the…
Diabetes mellitus is a disease that affects to hundreds of millions of people worldwide. Maintaining a good control of the disease is critical to avoid severe long-term complications. In recent years, several artificial pancreas systems…
The accretion of Gaia-Enceladus/Sausage (GES) onto the Milky Way (MW) is one of the most prominent features of the Galactic halo revealed by the combination of the Gaia satellite and large spectroscopic surveys. This massive accretion…
Deciphering gene regulatory networks is a central problem in computational biology. Here, we explore the use of multi-modal neural networks to learn predictive models of gene expression that include cis and trans regulatory components. We…
Yeast cells produce daughter cells through a DNA replication and mitosis cycle associated with checkpoints and governed by the cell cycle regulatory network. To ensure genome stability and genetic information inheritance, this regulatory…
Galactic archaeology represents a multidisciplinary approach aimed at unraveling the intricate history of the Milky Way galaxy through the study of its stellar populations. This abstract delves into the significance of galactic archaeology…
The evolution of Ly-alpha absorber counts is simulated for a model population of absorbing galaxies. The distribution of gas relative to galaxies could evolve between moderate and low redshifts, but constraints are needed on the strength…
Escherichia coli has long been used as a model organism due to the extensive experimental characterization of its pathways and molecular components. Take chemotaxis as an example, which allows bacteria to sense and swim in response to…
It has recently been suggested that the fundamental haploid-diploid cycle of eukaryotic sex exploits a rudimentary form of the Baldwin effect. Thereafter the other associated phenomena can be explained as evolution tuning the amount and…
New observations in favour of a significant role of secular evolution are reviewed: central star formation boosted in pseudo-bulge barred galaxies, relations between bulge and disk, evidence for rejuvenated bulges. Numerical simulations…
We study the evolution of the galactic globular cluster system to determine its initial mass-function and the fraction of halo stars that could have come from disrupted globular clusters. We study the cluster evolution under the influence…
Transgenerational inheritance of a trait is presumably affected by both genetic and environmental factors but remains poorly understood. We studied the effect of genetic polymorphisms on transgenerational inheritance of yeast segregants…
Construction of synthetic genetic networks requires the assembly of DNA fragments encoding functional biological parts in a defined order. Yet this may become a time-consuming procedure. To address this technical bottleneck, we have created…