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Agent-based modeling plays an essential role in gaining insights into biology, sociology, economics, and other fields. However, many existing agent-based simulation platforms are not suitable for large-scale studies due to the low…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-04-25 Lukas Breitwieser , Ahmad Hesam , Fons Rademakers , Juan Gómez Luna , Onur Mutlu

Motivation: Agent-based modeling is an indispensable tool for studying complex biological systems. However, existing simulators do not always take full advantage of modern hardware and often have a field-specific software design. Results:…

Agent-based modeling is indispensable for studying complex systems across many domains. However, existing simulation platforms exhibit two major issues: performance and modularity. Low performance prevents simulations with a large number of…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-03-17 Lukas Johannes Breitwieser

Multi-agent learning algorithms have been successful at generating superhuman planning in various games but have had limited impact on the design of deployed multi-agent planners. A key bottleneck in applying these techniques to multi-agent…

Artificial Intelligence · Computer Science 2025-02-19 Saman Kazemkhani , Aarav Pandya , Daphne Cornelisse , Brennan Shacklett , Eugene Vinitsky

Computational biology has increasingly turned to agent-based modeling to explore complex biological systems. Biological diffusion (diffusion, decay, secretion, and uptake) is a key driver of biological tissues. GPU computing can vastly…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-10-27 Matt Stack , Paul Macklin , Robert Searles , Sunita Chandrasekaran

Pedestrian movement, although ubiquitous and well-studied, is still not that well understood due to the complicating nature of the embedded social dynamics. Interest among researchers in simulating pedestrian movement and interactions has…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-12-17 Sankha Baran Dutta , Robert McLeod , Marcia Friesen

Agent-based simulation is an indispensable paradigm for studying complex systems. These systems can comprise billions of agents, requiring the computing resources of multiple servers to simulate. Unfortunately, the state-of-the-art…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-30 Lukas Breitwieser , Ahmad Hesam , Abdullah Giray Yağlıkçı , Mohammad Sadrosadati , Fons Rademakers , Onur Mutlu

Computer simulations have become a very powerful tool for scientific research. In order to facilitate research in computational biology, the BioDynaMo project aims at a general platform for biological computer simulations, which should be…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-08-18 Lukas Breitwieser , Roman Bauer , Alberto Di Meglio , Leonard Johard , Marcus Kaiser , Marco Manca , Manuel Mazzara , Fons Rademakers , Max Talanov

The study of biological systems witnessed a pervasive cross-fertilization between experimental investigation and computational methods. This gave rise to the development of new methodologies, able to tackle the complexity of biological…

Computational Engineering, Finance, and Science · Computer Science 2013-10-01 Daniela Besozzi , Giulio Caravagna , Paolo Cazzaniga , Marco Nobile , Dario Pescini , Alessandro Re

The complex regulatory dynamics of a biological network can be succinctly captured using discrete logic models. Given even sparse time-course data from the system of interest, previous work has shown that global optimization schemes are…

Molecular Networks · Quantitative Biology 2026-04-22 Joyce Reimer , Pranta Saha , Chris Chen , Neeraj Dhar , Brook Byrns , Steven Rayan , Gordon Broderick

BioDynaMo is a biological processes simulator developed by an international community of researchers and software engineers working closely with neuroscientists. The authors have been working on gene expression, i.e. the process by which…

Quantitative Methods · Quantitative Biology 2018-03-13 Sadyk Sayfullin , Fedor Akhmetov , Manuel Mazzara , Ruslan Mustafin , Victor Rivera

Due to decelerating gains in single-core CPU performance, computationally expensive simulations are increasingly executed on highly parallel hardware platforms. Agent-based simulations, where simulated entities act with a certain degree of…

Multiagent Systems · Computer Science 2018-07-04 Jiajian Xiao , Philipp Andelfinger , David Eckhoff , Wentong Cai , Alois Knoll

Classical molecular dynamics (MD) simulations are important tools in life and material sciences since they allow studying chemical and biological processes in detail. However, the inherent scalability problem of particle-particle…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-08-14 Michael Schaffner , Luca Benini

We present a hydrodynamic simulation system using the GPU compute shaders of DirectX for simulating virtual agent behaviors and navigation inside a smoothed particle hydrodynamical (SPH) fluid environment with real-time water mesh surface…

Computational Physics · Physics 2023-12-22 Xi Liu , Gizem Kayar , Ken Perlin

While most robotics simulation libraries are built for low-dimensional and intrinsically serial tasks, soft-body and multi-agent robotics have created a demand for simulation environments that can model many interacting bodies in parallel.…

Robotics · Computer Science 2019-11-26 Jacob Austin , Rafael Corrales-Fatou , Sofia Wyetzner , Hod Lipson

Large-scale molecular dynamics simulations with high accuracy have been increasingly popular for their capability to bridge the gap between atomistic modeling and mesoscale phenomena. Both machine learning potentials and enhanced sampling…

Computational Physics · Physics 2026-03-24 Haoting Zhang , Qiuhan Jia , Zhennan Zhang , Yijie Zhu , Zhongwei Zhang , Junjie Wang , Jiuyang Shi , Zheyong Fan , Jian Sun

Computer simulations have become a very powerful tool for scientific research. Given the vast complexity that comes with many open scientific questions, a purely analytical or experimental approach is often not viable. For example,…

Neural and Evolutionary Computing · Computer Science 2016-07-12 Roman Bauer , Lukas Breitwieser , Alberto Di Meglio , Leonard Johard , Marcus Kaiser , Marco Manca , Manuel Mazzara , Max Talanov

We present a GPU implementation of LAMMPS, a widely-used parallel molecular dynamics (MD) software package, and show 5x to 13x single node speedups versus the CPU-only version of LAMMPS. This new CUDA package for LAMMPS also enables…

Materials Science · Physics 2011-03-08 Christian R. Trott , Lars Winterfeld , Paul S. Crozier

We present Megaverse, a new 3D simulation platform for reinforcement learning and embodied AI research. The efficient design of our engine enables physics-based simulation with high-dimensional egocentric observations at more than 1,000,000…

Machine Learning · Computer Science 2021-07-22 Aleksei Petrenko , Erik Wijmans , Brennan Shacklett , Vladlen Koltun

This paper is a brief update on developments in the BioDynaMo project, a new platform for computer simulations for biological research. We will discuss the new capabilities of the simulator, important new concepts simulation methodology as…

Neural and Evolutionary Computing · Computer Science 2018-01-22 Leonard Johard , Lukas Breitwieser , Alberto Di Meglio , Marco Manca , Manuel Mazzara , Max Talanov
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