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A key parameter in models for the spread of infectious diseases is the basic reproduction number $R_0$, which is the expected number of secondary cases a typical infected primary case infects during its infectious period in a large mostly…

Populations and Evolution · Quantitative Biology 2017-09-05 Kristoffer Spricer , Pieter Trapman

We propose a novel approach to approximate the basic reproduction number $R_0$ as spectral radius of the Next-Generation Operator in time-periodic population models by characterizing the latter via evolution semigroups. Once birth/infection…

Numerical Analysis · Mathematics 2025-09-03 Dimitri Breda , Simone De Reggi , Jordi Ripoll

As the interactions between people increases, the impending menace of COVID-19 outbreaks materialize, and there is an inclination to apply lockdowns. In this context, it is essential to have easy-to-use indicators for people to use as a…

Populations and Evolution · Quantitative Biology 2021-01-26 Joaquín Salas

In this study we analyze the evolution of the effective reproduction number, $R$, through a SIR spreading process in heterogeneous networks; Characterizing its decay process allows to analytically study the effects of countermeasures on the…

Social and Information Networks · Computer Science 2022-07-26 Jhonatan Tavori , Hanoch Levy

In this paper we consider epidemic models of directly transmissible SIR (susceptible $\to$ infective $\to$ recovered) and SEIR (with an additional latent class) infections in fully-susceptible populations with a social structure, consisting…

Populations and Evolution · Quantitative Biology 2015-12-11 Frank Ball , Lorenzo Pellis , Pieter Trapman

This paper is an exploratory study of two epidemiological questions on a worldwide basis. How fast is the disease spreading? Are the restrictions (especially mobility restrictions) for people bring the expected effect? To answer the first…

Social and Information Networks · Computer Science 2021-08-30 Tatiana Petrova , Dmitri Soshnikov , Andrey Grunin

To control the current outbreak of the Coronavirus Disease 2019, constant monitoring of the epidemic is required since, as of today, no vaccines or antiviral drugs against it are known. We provide daily updated estimates of the reproduction…

Populations and Evolution · Quantitative Biology 2020-04-21 Thomas Hotz , Matthias Glock , Stefan Heyder , Sebastian Semper , Anne Böhle , Alexander Krämer

Modeling the spread of COVID-19 is crucial for informing public health policy. All models for COVID-19 epidemiology rely on parameters describing the dynamics of the infection process. The meanings of epidemiological parameters like R_0,…

Other Quantitative Biology · Quantitative Biology 2020-07-13 Yinon M. Bar-On , Ron Sender , Avi I. Flamholz , Rob Phillips , Ron Milo

We investigate the problem of estimating the distribution of the individual reproduction number governing the COVID-19 pandemic. Under the assumption that this random variable follows a Negative Binomial distribution, we focus on…

Applications · Statistics 2021-01-21 Alexander Braumann , Jonas Krampe , Jens-Peter Kreiss , Efstathios Paparoditis

In this article, we investigate the importance of demographic and contact patterns in determining the spread of COVID-19 and to the effectiveness of social distancing policies. We investigate these questions proposing an augmented…

Populations and Evolution · Quantitative Biology 2022-05-12 M. A. Ridenti , L. K. Teles , A. Maranhão , V. K. Teles

As widely known, the basic reproduction number plays a key role in weighing birth/infection and death/recovery processes in several models of population dynamics. In this general setting, its characterization as the spectral radius of next…

Numerical Analysis · Mathematics 2020-04-29 Dimitri Breda , Francesco Florian , Jordi Ripoll , Rossana Vermiglio

Since the beginning of the corona pandemic in March 2020, various parameters for describing the spread of the disease have been specified for Germany in addition to the daily infection figures (new infections and total infections), which…

Populations and Evolution · Quantitative Biology 2020-11-18 Thomas Götz , Silja Mohrmann , Robert Rockenfeller , Moritz Schäfer , Karunia Putra Wijaya

In epidemiology, the effective reproduction number $R_e$ is used to characterize the growth rate of an epidemic outbreak. In this paper, we investigate properties of $R_e$ for a modified SEIR model of COVID-19 in the city of Houston, TX…

Populations and Evolution · Quantitative Biology 2021-04-22 Christopher Thron , Vianney Mbazumutima , Luis Vargas Tamayo , Leonard Todjihounde

The outbreak of COVID-19 in 2020 has led to a surge in interest in the mathematical modeling of infectious diseases. Such models are usually defined as compartmental models, in which the population under study is divided into compartments…

Populations and Evolution · Quantitative Biology 2021-02-16 Malú Grave , Alex Viguerie , Gabriel F. Barros , Alessandro Reali , Alvaro L. G. A. Coutinho

An important issue in theoretical epidemiology is the epidemic threshold phenomenon, which specify the conditions for an epidemic to grow or die out. In standard (mean-field-like) compartmental models the concept of the basic reproductive…

Biological Physics · Physics 2007-05-23 D. Alves , V. J. Haas , A. Caliri

The basic reproduction number R0 -- the number of individuals directly infected by an infectious person in an otherwise susceptible population -- is arguably the most widely used estimator of how severe an epidemic outbreak can be. This…

Populations and Evolution · Quantitative Biology 2016-03-18 Petter Holme , Naoki Masuda

For nearly a century, the initial reproduction number (R0) has been used as a one number summary to compare outbreaks of infectious disease, yet there is no `standard' estimator for R0. Difficulties in estimating R0 arise both from how a…

Populations and Evolution · Quantitative Biology 2020-03-25 Shannon Gallagher , Andersen Chang , William F. Eddy

We consider an epidemic spreading in a city which is divided geographically into different districts. We introduce the reproduction matrix $\R=\bigl(R(i,j)\bigr)$ between districts, where $R(i,j)$ is the mean number of individuals in…

Physics and Society · Physics 2020-05-20 Vicente Acuña , María Paz Cortés , Andrew Hart , Servet Martínez , Juan Carlos Maureira

This study investigates the utilization of various mathematical models for comprehending and managing outbreaks of infectious diseases, with a specific focus on how different distributions of incubation times influence predictions regarding…

Adaptation and Self-Organizing Systems · Physics 2024-03-08 Eric Rozan , Marcelo N Kuperman , Sebastian Bouzat

A key problem in modelling the evolution dynamics of infectious diseases is the mathematical representation of the mechanism of transmission of the contagion. Models with a finite number of subpopulations can be described via systems of…

Optimization and Control · Mathematics 2017-03-09 Sebastian Anita , Vincenzo Capasso