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Understanding sickle cell dynamics requires accurate identification of morphological transitions under diverse biophysical conditions, particularly in densely packed and overlapping cell populations. Here, we present an automated deep…

Computer Vision and Pattern Recognition · Computer Science 2026-02-06 Nikhil Kadivar , Guansheng Li , Jianlu Zheng , Ming Dao , George Em Karniadakis , Mengjia Xu

Data imbalance between common and rare diseases during model training often causes intelligent diagnosis systems to have biased predictions towards common diseases. The state-of-the-art approaches apply a two-stage learning framework to…

Computer Vision and Pattern Recognition · Computer Science 2022-07-15 Chenghua Zeng , Huijuan Lu , Kanghao Chen , Ruixuan Wang , Wei-Shi Zheng

Classification data sets with skewed class proportions are called imbalanced. Class imbalance is a problem since most machine learning classification algorithms are built with an assumption of equal representation of all classes in the…

Machine Learning · Computer Science 2022-12-22 Azal Ahmad Khan

The application of machine learning techniques to the medical domain is especially challenging due to the required level of precision and the incurrence of huge risks of minute errors. Employing these techniques to a more complex subdomain…

Computer Vision and Pattern Recognition · Computer Science 2021-10-19 Ekta Gavas , Kaustubh Olpadkar

White blood cells (WBC) are important parts of our immune system, and they protect our body against infections by eliminating viruses, bacteria, parasites and fungi. The number of WBC types and the total number of WBCs provide important…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Sibasish Dhibar

Human blood primarily comprises plasma, red blood cells, white blood cells, and platelets. It plays a vital role in transporting nutrients to different organs, where it stores essential health-related data about the human body. Blood cells…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Rabia Asghar , Sanjay Kumar , Paul Hynds , Abeera Mahfooz

Differing from traditional semi-supervised learning, class-imbalanced semi-supervised learning presents two distinct challenges: (1) The imbalanced distribution of training samples leads to model bias towards certain classes, and (2) the…

Machine Learning · Computer Science 2023-12-29 Lan Li , Bowen Tao , Lu Han , De-chuan Zhan , Han-jia Ye

Automating white blood cell classification for diagnosis of leukaemia is a promising alternative to time-consuming and resource-intensive examination of cells by expert pathologists. However, designing robust algorithms for classification…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Siddharth Srivastava , Adam Smith , Scott Brooks , Jack Bacon , Till Bretschneider

Chromosome analysis and identification from metaphase images is a critical part of cytogenetics based medical diagnosis. It is mainly used for identifying constitutional, prenatal and acquired abnormalities in the diagnosis of genetic…

Computer Vision and Pattern Recognition · Computer Science 2022-09-13 Amritha S Pallavoor , Prajwal A , Sundareshan TS , Sreekanth K Pallavoor

Certain cancer types, notably pancreatic cancer, are difficult to detect at an early stage, motivating robust biomarker-based screening. Liquid biopsies enable non-invasive monitoring of circulating biomarkers, but typical machine learning…

Machine Learning · Computer Science 2025-11-21 Chongmin Lee , Jihie Kim

In many real-world binary classification tasks (e.g. detection of certain objects from images), an available dataset is imbalanced, i.e., it has much less representatives of a one class (a minor class), than of another. Generally, accurate…

Machine Learning · Statistics 2017-07-14 Evgeny Burnaev , Pavel Erofeev , Artem Papanov

Machine learning has endless applications in the health care industry. White blood cell classification is one of the interesting and promising area of research. The classification of the white blood cells plays an important part in the…

Computer Vision and Pattern Recognition · Computer Science 2021-12-14 Nalla Praveen , Narinder Singh Punn , Sanjay Kumar Sonbhadra , Sonali Agarwal , M. Syafrullah , Krisna Adiyarta

Segmentation and classification of cell nuclei in histopathology images using deep neural networks (DNNs) can save pathologists' time for diagnosing various diseases, including cancers, by automating cell counting and morphometric…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 Amruta Parulekar , Utkarsh Kanwat , Ravi Kant Gupta , Medha Chippa , Thomas Jacob , Tripti Bameta , Swapnil Rane , Amit Sethi

Binary classification (BC) is a practical task that is ubiquitous in real-world problems, such as distinguishing healthy and unhealthy objects in biomedical diagnostics and defective and non-defective products in manufacturing inspections.…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Imam Mustafa Kamal , Hyerim Bae

Automatic detection of leukemic B-lymphoblast cancer in microscopic images is very challenging due to the complicated nature of histopathological structures. To tackle this issue, an automatic and robust diagnostic system is required for…

Image and Video Processing · Electrical Eng. & Systems 2019-09-27 Sara Hosseinzadeh Kassani , Peyman Hosseinzadeh kassani , Michal J. Wesolowski , Kevin A. Schneider , Ralph Deters

Recognizing the types of white blood cells (WBCs) in microscopic images of human blood smears is a fundamental task in the fields of pathology and hematology. Although previous studies have made significant contributions to the development…

Image and Video Processing · Electrical Eng. & Systems 2023-05-22 Satoshi Tsutsui , Zhengyang Su , Bihan Wen

The accurate automated classification of variable stars into their respective sub-types is difficult. Machine learning based solutions often fall foul of the imbalanced learning problem, which causes poor generalisation performance in…

Instrumentation and Methods for Astrophysics · Physics 2020-03-18 Zafiirah Hosenie , Robert Lyon , Benjamin Stappers , Arrykrishna Mootoovaloo , Vanessa McBride

Medical image segmentation methods are generally designed as fully-supervised to guarantee model performance, which require a significant amount of expert annotated samples that are high-cost and laborious. Semi-supervised image…

Computer Vision and Pattern Recognition · Computer Science 2023-10-10 Xiangyu Zhao , Zengxin Qi , Sheng Wang , Qian Wang , Xuehai Wu , Ying Mao , Lichi Zhang

The manual evaluation, classification and counting of biological objects demands for an enormous expenditure of time and subjective human input may be a source of error. Investigating the shape of red blood cells (RBCs) in microcapillary…

Biological Physics · Physics 2018-06-22 Alexander Kihm , Lars Kaestner , Christian Wagner , Stephan Quint

The poor contrast and the overlapping of cervical cell cytoplasm are the major issues in the accurate segmentation of cervical cell cytoplasm. This paper presents an automated unsupervised cytoplasm segmentation approach which can…

Computer Vision and Pattern Recognition · Computer Science 2018-07-16 Pranav Kumar , S L Happy , Swarnadip Chatterjee , Debdoot Sheet , Aurobinda Routray