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Retinal fundus images provide valuable insights into the human eye's interior structure and crucial features, such as blood vessels, optic disk, macula, and fovea. However, accurate segmentation of retinal blood vessels can be challenging…

Image and Video Processing · Electrical Eng. & Systems 2025-06-24 Atifa Kalsoom , M. A. Iftikhar , Amjad Ali , Zubair Shah , Shidin Balakrishnan , Hazrat Ali

We present a weakly supervised deep learning method to perform instance segmentation of cells present in microscopy images. Annotation of biomedical images in the lab can be scarce, incomplete, and inaccurate. This is of concern when…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Fidel A. Guerrero-Peña , Pedro D. Marrero Fernandez , Tsang Ing Ren , Alexandre Cunha

We propose performing imbalanced classification by regrouping majority classes into small classes so that we turn the problem into balanced multiclass classification. This new idea is dramatically different from popular loss reweighting and…

Computer Vision and Pattern Recognition · Computer Science 2022-10-28 Le Peng , Yash Travadi , Rui Zhang , Ying Cui , Ju Sun

Red blood cells are highly deformable and present in various shapes. In blood cell disorders, only a subset of all cells is morphologically altered and relevant for the diagnosis. However, manually labeling of all cells is laborious,…

Computer Vision and Pattern Recognition · Computer Science 2020-07-24 Ario Sadafi , Asya Makhro , Anna Bogdanova , Nassir Navab , Tingying Peng , Shadi Albarqouni , Carsten Marr

Automated analysis of tissue sections allows a better understanding of disease biology and may reveal biomarkers that could guide prognosis or treatment selection. In digital pathology, less abundant cell types can be of biological…

Image and Video Processing · Electrical Eng. & Systems 2021-02-24 Yeman Brhane Hagos , Catherine SY Lecat , Dominic Patel , Lydia Lee , Thien-An Tran , Manuel Rodriguez- Justo , Kwee Yong , Yinyin Yuan

Hematological disorders, which involve a variety of malignant conditions and genetic diseases affecting blood formation, present significant diagnostic challenges. One such major challenge in clinical settings is differentiating…

Image and Video Processing · Electrical Eng. & Systems 2024-11-27 Buddhadev Goswami , Adithya B. Somaraj , Prantar Chakrabarti , Ravindra Gudi , Nirmal Punjabi

Class imbalance is a pervasive issue in the field of disease classification from medical images. It is necessary to balance out the class distribution while training a model for decent results. However, in the case of rare medical diseases,…

Image and Video Processing · Electrical Eng. & Systems 2024-02-21 Aminul Huq , Md Tanzim Reza , Shahriar Hossain , Shakib Mahmud Dipto

Pixel-level analysis of blood images plays a pivotal role in diagnosing blood-related diseases, especially Anaemia. These analyses mainly rely on an accurate diagnosis of morphological deformities like shape, size, and precise pixel…

Image and Video Processing · Electrical Eng. & Systems 2022-02-11 Muhammad Shahzad , Arif Iqbal Umar , Syed Hamad Shirazi , Israr Ahmed Shaikh

In this paper we address imbalanced binary classification (IBC) tasks. Applying resampling strategies to balance the class distribution of training instances is a common approach to tackle these problems. Many state-of-the-art methods find…

Machine Learning · Computer Science 2022-05-31 Vitor Cerqueira , Luis Torgo , Paula Branco , Colin Bellinger

Recently, deep learning models have achieved great success in computer vision applications, relying on large-scale class-balanced datasets. However, imbalanced class distributions still limit the wide applicability of these models due to…

Computer Vision and Pattern Recognition · Computer Science 2021-08-05 Yechan Kim , Younkwan Lee , Moongu Jeon

The diagnosis of blood-based diseases often involves identifying and characterizing patient blood samples. Automated methods to detect and classify blood cell subtypes have important medical applications. Automated medical image processing…

Computer Vision and Pattern Recognition · Computer Science 2021-06-24 Sai Sukruth Bezugam

The classification of white blood cells (WBCs) from peripheral blood smears is critical for the diagnosis of leukemia. However, automated approaches still struggle due to challenges including class imbalance, domain shift, and morphological…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Antony Gitau , Martin Paulson , Bjørn-Jostein Singstad , Karl Thomas Hjelmervik , Ola Marius Lysaker , Veralia Gabriela Sanchez

Automatic skin lesion classification from dermoscopy images is important for the early diagnosis of skin diseases such as melanoma. Class imbalance in skin lesion datasets, notably the defects in the representation of malignant(cancerous)…

Quantitative Methods · Quantitative Biology 2025-12-19 Ariful Islam Khandaker , Abdullah Al Shafi , Mohiuddin Ahmad

Accurate multi-class segmentation is a long-standing challenge in medical imaging, especially in scenarios where classes share strong similarity. Segmenting retinal blood vessels in retinal photographs is one such scenario, in which…

Image and Video Processing · Electrical Eng. & Systems 2021-12-10 Yukun Zhou , Moucheng Xu , Yipeng Hu , Hongxiang Lin , Joseph Jacob , Pearse A. Keane , Daniel C. Alexander

In this study, we systematically investigate the impact of class imbalance on classification performance of convolutional neural networks (CNNs) and compare frequently used methods to address the issue. Class imbalance is a common problem…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Mateusz Buda , Atsuto Maki , Maciej A. Mazurowski

Leukemia (blood cancer) is an unusual spread of White Blood Cells or Leukocytes (WBCs) in the bone marrow and blood. Pathologists can diagnose leukemia by looking at a person's blood sample under a microscope. They identify and categorize…

Computer Vision and Pattern Recognition · Computer Science 2023-03-13 Mohammad Zolfaghari , Hedieh Sajedi

Circulating blood cell clusters (CCCs) containing red blood cells (RBCs), white blood cells(WBCs), and platelets are significant biomarkers linked to conditions like thrombosis, infection, and inflammation. Flow cytometry, paired with…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Suqiang Ma , Subhadeep Sengupta , Yao Lee , Beikang Gu , Xianyan Chen , Xianqiao Wang , Yang Liu , Mengjia Xu , Galit H. Frydman , He Li

In this work we propose an approach to select the classification method and features, based on the state-of-the-art, with best performance for diagnostic support through peripheral blood smear images of red blood cells. In our case we used…

Machine Learning · Computer Science 2020-10-12 Nataša Petrović , Gabriel Moyà-Alcover , Antoni Jaume-i-Capó , Manuel González-Hidalgo

Real-world classification domains, such as medicine, health and safety, and finance, often exhibit imbalanced class priors and have asynchronous misclassification costs. In such cases, the classification model must achieve a high recall…

Machine Learning · Computer Science 2021-05-11 Michał Koziarski , Colin Bellinger , Michał Woźniak

The segmentation and classification of carotid plaques in ultrasound images play important roles in the treatment of atherosclerosis and assessment for the risk of stroke. Although deep learning methods have been used for carotid plaque…

Image and Video Processing · Electrical Eng. & Systems 2023-11-21 Haitao Gan , Ran Zhou , Yanghan Ou , Furong Wang , Xinyao Cheng , Aaron Fenster