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Testing is a crucial control mechanism for an epidemic outbreak because it enables the health authority to detect and isolate the infected cases, thereby limiting the disease transmission to susceptible people, when no effective treatment…

To curb the spread of COVID-19, many governments around the world have implemented tiered lockdowns with varying degrees of stringency. Lockdown levels are typically increased when the disease spreads and reduced when the disease abates. A…

Populations and Evolution · Quantitative Biology 2020-11-16 Laurentz E. Olivier , Stefan Botha , Ian K. Craig

We consider control of reaction and population systems by deterministically imposed transitions between the states with different numbers of particles or individuals. Even where the imposed transitions are significantly less frequent than…

Statistical Mechanics · Physics 2011-02-07 M. Khasin , M. I. Dykman

Once an epidemic outbreak has been effectively contained through non-pharmaceutical interventions, a safe protocol is required for the subsequent release of social distancing restrictions to prevent a disastrous resurgence of the infection.…

Without vaccines and treatments, societies must rely on non-pharmaceutical intervention strategies to control the spread of emerging diseases such as COVID-19. Though complete lockdown is epidemiologically effective, because it eliminates…

Populations and Evolution · Quantitative Biology 2021-01-08 Jason Hindes , Simone Bianco , Ira B. Schwartz

Epidemics of infectious diseases posing a serious risk to human health have occurred throughout history. During recent epidemics there has been much debate about policy, including how and when to impose restrictions on behaviour.…

Theoretical Economics · Economics 2024-04-08 Simon K. Schnyder , John J. Molina , Ryoichi Yamamoto , Matthew S. Turner

In the face of elevated pandemic risk, is it necessary to completely lock down the population, imposing extreme social distancing? Canonical epidemiological models suggest this may be unavoidable for months at a time, despite the heavy…

Physics and Society · Physics 2020-04-21 Eric Friedman , John Friedman , Simon Johnson , Adam Landsberg

We show that the basic reproduction number of an SIS patch model with standard incidence is either strictly decreasing and strictly convex with respect to the diffusion coefficient of infected subpopulation if the patch reproduction numbers…

Populations and Evolution · Quantitative Biology 2020-01-03 Daozhou Gao , Chao-Ping Dong

Strong social distancing restrictions have been crucial to controlling the COVID-19 outbreak thus far, and the next question is when and how to relax these restrictions. A sequential timing of relaxing restrictions across groups is explored…

Populations and Evolution · Quantitative Biology 2020-05-14 Henry Zhao , Zhilan Feng , Carlos Castillo-Chavez , Simon A. Levin

We propose a simple SIR model in order to investigate the impact of various confinement strategies on a most virulent epidemic. Our approach is motivated by the current COVID-19 pandemic. The main hypothesis is the existence of two…

Populations and Evolution · Quantitative Biology 2020-12-30 G. Nakamura , B. Grammaticos , M. Badoual

A cholera transmission model incorporating water-borne and horizontal transmissions as well as infectivity of deceased individuals is formulated and studied. The model also describes an imperfect and waning vaccination. Global stability of…

Populations and Evolution · Quantitative Biology 2025-04-11 Abdramane Annour Saad , Julien Arino , Patrick M Tchepmo Djomegni , Mahamat S Daoussa Haggar

Transmission dynamics of infectious diseases are often studied using compartmental mathematical models, which are commonly represented as systems of autonomous ordinary differential equations. A key step in the analysis of such models is to…

Populations and Evolution · Quantitative Biology 2025-12-15 David J. D. Earn , C. Connell McCluskey

We demonstrate that the epidemic renormalisation group approach to pandemics provides an effective and simple way to investigate the dynamics of disease transmission and spreading across different regions of the world. The framework also…

Physics and Society · Physics 2020-05-12 Giacomo Cacciapaglia , Francesco Sannino

The mitigation of an infectious disease spreading has recently gained considerable attention from the research community. It may be obtained by adopting sanitary measurements social rules, together with an extensive vaccination campaign.…

Social and Information Networks · Computer Science 2022-02-17 Francesco Petrizzelli , Pietro Hiram Guzzi , Tommaso Mazza

The COVID-19 pandemic began over two years ago, yet schools, businesses, and other organizations are still struggling to keep the risk of disease outbreak low while returning to (near) normal functionality. Observations from these past…

Populations and Evolution · Quantitative Biology 2022-02-02 Sarah C. Fay , Dalton J. Jones , Munther A. Dahleh , A. E. Hosoi

In this study initially, we propose an age structured model and calculate the equilibrium points and basic reproduction number. Later we propose an optimal control problem to understand the roles of treatment in controlling the epidemic.…

Dynamical Systems · Mathematics 2020-12-15 Bishal Chhetri , D. K. K Vamsi , Carani B Sanjeevi

We analyze equilibrium behavior and optimal policy within a Susceptible-Infected-Recovered epidemic model augmented with potentially undiagnosed agents who infer their health status and a social planner with imperfect enforcement of social…

Theoretical Economics · Economics 2022-11-01 Thomas Phelan , Alexis Akira Toda

Optimizing the impact on the economy of control strategies aiming at containing the spread of COVID-19 is a critical challenge. We use daily new case counts of COVID-19 patients reported by local health administrations from different…

Populations and Evolution · Quantitative Biology 2021-03-12 Afroza Shirin , Yen Ting Lin , Francesco Sorrentino

Non-pharmaceutical measures such as preventive quarantines, remote working, school and workplace closures, lockdowns, etc. have shown effectivenness from an epidemic control perspective; however they have also significant negative…

We consider three regions with different public health conditions. In the absence of migration among these regions, the first two have good health conditions and the disease free state is stable; for the third region, on the other hand, the…

Populations and Evolution · Quantitative Biology 2017-12-22 Fabio A. C. C. Chalub , Tiago J. Costa , Paula Patrício