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Numerical simulations of waves in highly heterogeneous media have important applications, but direct computations are prohibitively expensive. In this paper, we develop a new generalized multiscale finite element method with the aim of…

Numerical Analysis · Mathematics 2015-09-09 Eric T. Chung , Wing Tat Leung

We developed an optical-resolution photoacoustic microscope (OR-PAM) capable of changing focal plane with high-speed by using a tunable acoustic gradient (TAG) lens. In our system, a TAG lens is designed to continuously changing the focal…

Optics · Physics 2020-09-09 Xianlin Song

Aerosol injectors applied in single-particle diffractive imaging experiments demonstrated their potential in efficiently delivering nanoparticles with high density. Continuous optimization of injector design is crucial for achieving…

We explore a scheme for guiding cold atoms through a hollow Bessel beam generated by a single axicon and a lens from a 2D magneto-optical trap toward a science chamber. We compare the Bessel beam profiles measured along the optical axis to…

Photoacoustic imaging is an emerging technology based on the photoacoustic effect that has developed rapidly in recent years. It combines the high contrast of optical imaging and the high penetration and high resolution of acoustic imaging.…

We present a versatile and highly configurable scanning acoustic platform. This platform, comprising of a high frequency transducer, bespoke positioning system and temperature-regulated sample unit, enables the acoustic probing of materials…

Materials Science · Physics 2010-02-24 N G Parker , P V Nelson , M J W Povey

We report a systematic treatment of the holographic generation of electron Bessel beams, with a view to applications in electron microscopy. We describe in detail the theory underlying hologram patterning, as well as the actual…

Spatial gradients of diffusible signalling molecules play crucial roles in controlling diverse cellular behaviour such as cell differentiation, tissue patterning and chemotaxis. In this paper, we report the design and testing of a…

Quantitative Methods · Quantitative Biology 2016-12-15 Yasushi Saka , Murray MacPherson , Claudiu V. Giuraniuc

This publication extends the HoloTile framework to three dimensions, introducing the ability to generate arbitrary dynamic patterns composed of extended depth-of-field non-diffractive beamlets with theoretically 100% diffraction efficiency.…

Optics · Physics 2024-06-03 Andreas Erik Gejl Madsen , Jesper Glückstad

Optoacoustic image formation is conventionally based upon ultrasound time-of-flight readings from multiple detection positions. Herein, we exploit acoustic scattering to physically encode the position of optical absorbers in the acquired…

Biological Physics · Physics 2019-10-30 Xose Luis Dean-Ben , Ali Ozbek , Hernan Lopez-Schier , Daniel Razansky

Nonlinear optical microscopy techniques have emerged as a set of successful tools for biological imaging. Stimulated emission microscopy belongs to a small subset of pump-probe techniques which can image non-fluorescent samples without…

One primary technical challenge in photoacoustic microscopy (PAM) is the necessary compromise between spatial resolution and imaging speed. In this study, we propose a novel application of deep learning principles to reconstruct…

Image and Video Processing · Electrical Eng. & Systems 2020-06-02 Anthony DiSpirito , Daiwei Li , Tri Vu , Maomao Chen , Dong Zhang , Jianwen Luo , Roarke Horstmeyer , Junjie Yao

Multifocus microscopy enables recording of entire volumes in a single camera exposure. In dense samples, multifocus microscopy is severely hampered by background haze. Here, we introduce a scalable multifocus method that incorporates…

Computer simulations have become an important tool across the biomedical sciences and beyond. For many important problems several different models or hypotheses exist and choosing which one best describes reality or observed data is not…

Quantitative Methods · Quantitative Biology 2010-01-20 Tina Toni , Michael P. H. Stumpf

We present a system for measuring the amplitude and phase profiles of the pressure field of a harmonic acoustic wave with the goal of reconstructing the volumetric sound field. Unlike optical holograms that cannot be reconstructed exactly…

Soft Condensed Matter · Physics 2018-08-09 Hillary W. Gao , Kimberly I. Mishra , Annemarie Winters , Sidney Wolin , David G. Grier

We present an easy-to-use and lightweight surface and volume mesh sampling standalone application tailored for the needs of particle-based simulation. We describe the surface and volume sampling algorithms used in LEAVEN in a…

Graphics · Computer Science 2023-08-04 Alexander Sommer , Ulrich Schwanecke

Photonic sintering (PS) offers an ultra-fast, contact-free alternative to conventional sintering and has demonstrated its potential for enhancing the sinterability of acceptor-doped barium zirconate (BZY) ceramics. However, a central…

Materials Science · Physics 2026-02-02 Junlong Ma , Yangyiwei Yang , Julian N. Ebert , Wolfgang Rheinheimer , Bai-Xiang Xu

Continuum robots are advancing bronchoscopy procedures by accessing complex lung airways and enabling targeted interventions. However, their development is limited by the lack of realistic training and test environments: Real data is…

Photoacoustic microscopy (PAM) is a promising imaging modality because it is able to reveal optical absorption contrast in high resolution on the order of a micrometer. It can be applied in an endoscopic approach by implementing PAM into a…

Medical Physics · Physics 2019-11-22 Zhendong Guo , Zhanhong Ye , Weihao Shao , Lili Jing , Sung-Liang Chen

Beam shaping - the ability to engineer the phase and the amplitude of massive and massless particles - has long interested scientists working on communication, imaging and the foundations of quantum mechanics. In light optics, the shaping…