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The correct evaluation of the reproductive number $R$ for COVID-19 -- which characterizes the average number of secondary cases generated by each typical primary case -- is central in the quantification of the potential scope of the…

Applications · Statistics 2021-04-15 Claire Donnat , Susan Holmes

The recent COVID-19 pandemic has shown that when the reproduction number is high and there are no proper measurements in place, the number of infected people can increase dramatically in a short time, producing a phenomenon that many…

Populations and Evolution · Quantitative Biology 2022-09-20 Jonathan A. Chávez Casillas

Epidemic disease spreading is conventionally often modelled and analyzed by means of rate and diffusion equations, following the paradigms of well-controlled chemical reactions and diffusive dynamics in a test tube. Yet, serious worries…

Physics and Society · Physics 2023-01-03 Klaus Kroy

Human to human transmissible infectious diseases spread in a population using human interactions as its transmission vector. The early stages of such an outbreak can be modeled by a graph whose edges encode these interactions between…

Populations and Evolution · Quantitative Biology 2020-06-11 Goncalo Oliveira

The interplay of biological, social, structural and random factors makes disease forecasting extraordinarily complex. The course of an epidemic exhibits average growth dynamics determined by features of the pathogen and the population, yet…

Populations and Evolution · Quantitative Biology 2022-02-24 Andrea J. Allen , Mariah C. Boudreau , Nicholas J. Roberts , Antoine Allard , Laurent Hébert-Dufresne

Coronavirus COVID-19 spreads through the population mostly based on social contact. To gauge the potential for widespread contagion, to cope with associated uncertainty and to inform its mitigation, more accurate and robust modelling is…

A primary quantity of interest in the study of infectious diseases is the average number of new infections that an infected person produces. This so-called reproduction number has significant implications for the disease progression. There…

The fundamental models of epidemiology describe the progression of an infectious disease through a population using compartmentalized differential equations, but do not incorporate population-level heterogeneity in infection susceptibility.…

Populations and Evolution · Quantitative Biology 2023-08-04 Christopher Rose , Andrew J. Medford , C. Franklin Goldsmith , Tejs Vegge , Joshua S. Weitz , Andrew A. Peterson

The outbreak and propagation of COVID-19 have posed a considerable challenge to modern society. In particular, the different restrictive actions taken by governments to prevent the spread of the virus have changed the way humans interact…

Populations and Evolution · Quantitative Biology 2021-10-05 Sebastian Contreras , H. Andres Villavicencio , David Medina-Ortiz , Juan Pablo Biron-Lattes , Alvaro Olivera-Nappa

SARS-CoV-2 causing COVID-19 disease has moved rapidly around the globe, infecting millions and killing hundreds of thousands. The basic reproduction number, which has been widely used and misused to characterize the transmissibility of the…

Populations and Evolution · Quantitative Biology 2020-05-29 Benjamin M. Althouse , Edward A. Wenger , Joel C. Miller , Samuel V. Scarpino , Antoine Allard , Laurent Hébert-Dufresne , Hao Hu

Epidemics unfold by means of a spreading process from each infected individual to a random number of secondary cases. It has been claimed that the so-called superspreading events in COVID-19 are governed by a power-law tailed distribution…

Physics and Society · Physics 2022-06-29 Carles Falcó , Álvaro Corral

The emergence due to the outbreak of the COVID-19 disease, caused by the SARS-CoV-2 virus, suddenly erupted at the beginning of 2020 in China and soon spread worldwide. This has caused an outstanding increase on research about the virus…

Physics and Society · Physics 2022-03-30 Daniele Vilone , Giulia Andrighetto

We investigate the problem of estimating the distribution of the individual reproduction number governing the COVID-19 pandemic. Under the assumption that this random variable follows a Negative Binomial distribution, we focus on…

Applications · Statistics 2021-01-21 Alexander Braumann , Jonas Krampe , Jens-Peter Kreiss , Efstathios Paparoditis

In this work, we aim to understand the influence of the heterogeneity of infection rates on the Susceptible-Infected-Susceptible (SIS) epidemic spreading. Employing the classic SIS model as the benchmark, we study the influence of the…

Physics and Society · Physics 2016-04-06 Bo Qu , Huijuan Wang

The basic reproductive number -- $R_0$ -- is one of the most common and most commonly misapplied numbers in public health. Although often used to compare outbreaks and forecast pandemic risk, this single number belies the complexity that…

Populations and Evolution · Quantitative Biology 2020-04-15 Laurent Hébert-Dufresne , Benjamin M. Althouse , Samuel V. Scarpino , Antoine Allard

Motivated by the increasing number of COVID-19 cases that have been observed in many countries after the vaccination and relaxation of non-pharmaceutical interventions, we propose a mathematical model on time-varying networks for the spread…

Dynamical Systems · Mathematics 2022-03-09 Kathinka Frieswijk , Lorenzo Zino , Ming Cao

Intent of this research is to explore how mathematical models, specifically Susceptible-Infected-Removed (SIR) model, can be utilized to forecast peak outbreak timeline of COVID-19 epidemic amongst a population of interest starting from the…

Populations and Evolution · Quantitative Biology 2020-09-14 Amit Tewari

Most models of epidemic spread, including many designed specifically for COVID-19, implicitly assume mass-action contact patterns and undirected contact networks, meaning that the individuals most likely to spread the disease are also the…

In stochastic modeling of infectious diseases, it has been established that variations in infectivity affect the probability of a major outbreak, but not the shape of the curves during a major outbreak, which is predicted by deterministic…

Physics and Society · Physics 2022-12-12 F Rousse , M Carlsson , M Ogren , B Kalischer Wellander

Motivated by the importance of individual differences in risk perception and behavior change in people's responses to infectious disease outbreaks (particularly the ongoing COVID-19 pandemic), we propose a heterogeneous…

Physics and Society · Physics 2020-11-04 Yang Ye , Qingpeng Zhang , Zhongyuan Ruan , Zhidong Cao , Qi Xuan , Daniel Dajun Zeng
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