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DNA sequence alignment is an important workload in computational genomics. Reference-guided DNA assembly involves aligning many read sequences against candidate locations in a long reference genome. To reduce the computational load of this…

Hardware Architecture · Computer Science 2024-01-23 Courtney Golden , Dan Ilan , Nicholas Cebry , Christopher Batten

A lot of recent progress has been made in ultra low-bit quantization, promising significant improvements in latency, memory footprint and energy consumption on edge devices. Quantization methods such as Learned Step Size Quantization can…

Computing on encrypted data is a promising approach to reduce data security and privacy risks, with homomorphic encryption serving as a facilitator in achieving this goal. In this work, we accelerate homomorphic operations using the…

Cryptography and Security · Computer Science 2023-10-04 Harshita Gupta , Mayank Kabra , Juan Gómez-Luna , Konstantinos Kanellopoulos , Onur Mutlu

Neural network (NN) accelerators with multi-chip-module (MCM) architectures enable integration of massive computation capability; however, they face challenges of computing resource underutilization and off-chip communication overheads.…

Hardware Architecture · Computer Science 2026-02-17 Zongle Huang , Hongyang Jia , Kaiwei Zou , Yongpan Liu

Fully Homomorphic Encryption (FHE) allows for computation directly on encrypted data and enables privacy-preserving neural inference in the cloud. Prior work has focused on models with dense inputs (e.g., CNNs), with less attention given to…

Cryptography and Security · Computer Science 2026-02-23 Karthik Garimella , Austin Ebel , Gabrielle De Micheli , Brandon Reagen

Time series analysis is a key technique for extracting and predicting events in domains as diverse as epidemiology, genomics, neuroscience, environmental sciences, economics, and more. Matrix profile, the state-of-the-art algorithm to…

Computational chemistry has become an important tool to predict and understand molecular properties and reactions. Even though recent years have seen a significant growth in new algorithms and computational methods that speed up quantum…

Chemical Physics · Physics 2023-07-26 Albert Thie , Maximilian F. S. J. Menger , Shirin Faraji

Computing-in-memory (CIM) is an emerging computing paradigm, offering noteworthy potential for accelerating neural networks with high parallelism, low latency, and energy efficiency compared to conventional von Neumann architectures.…

Neural and Evolutionary Computing · Computer Science 2024-09-30 Kam Chi Loong , Shihao Han , Sishuo Liu , Ning Lin , Zhongrui Wang

PIM architectures aim to reduce data transfer costs between processors and memory by integrating processing units within memory layers. Prior PIM architectures have shown potential to improve energy efficiency and performance. However, such…

Hardware Architecture · Computer Science 2025-10-10 Parker Hao Tian , Zahra Yousefijamarani , Alaa Alameldeen

Homomorphic encryption (HE) is a promising technology for confidential cloud computing, as it allows computations on encrypted data. However, HE is computationally expensive and often memory-bound on conventional computer architectures.…

Cryptography and Security · Computer Science 2026-05-12 Niklas Klinger , Jonas Sander , Peterson Yuhala , Pascal Felber , Thomas Eisenbarth

Expanding Deep Learning applications toward edge computing demands architectures capable of delivering high computational performance and efficiency while adhering to tight power and memory constraints. Digital In-Memory Computing (DIMC)…

Hardware Architecture · Computer Science 2026-02-03 Tommaso Spagnolo , Cristina Silvano , Riccardo Massa , Filippo Grillotti , Thomas Boesch , Giuseppe Desoli

Over the past few years, silicon photonics-based computing has emerged as a promising alternative to CMOS-based computing for Deep Neural Networks (DNN). Unfortunately, the non-linear operations and the high-precision requirements of DNNs…

Poor DRAM technology scaling over the course of many years has caused DRAM-based main memory to increasingly become a larger system bottleneck. A major reason for the bottleneck is that data stored within DRAM must be moved across a…

Hardware Architecture · Computer Science 2018-02-02 Saugata Ghose , Kevin Hsieh , Amirali Boroumand , Rachata Ausavarungnirun , Onur Mutlu

Photonics is a promising technology to accelerate Deep Neural Networks as it can use optical interconnects to reduce data movement energy and it enables low-energy, high-throughput optical-analog computations. To realize these benefits in a…

Emerging Technologies · Computer Science 2024-11-01 Tanner Andrulis , Gohar Irfan Chaudhry , Vinith M. Suriyakumar , Joel S. Emer , Vivienne Sze

The cost involved in training deep neural networks (DNNs) on von-Neumann architectures has motivated the development of novel solutions for efficient DNN training accelerators. We propose a hybrid in-memory computing (HIC) architecture for…

Hardware Architecture · Computer Science 2021-02-11 Vinay Joshi , Wangxin He , Jae-sun Seo , Bipin Rajendran

We present a portable platform, called PIC_ENGINE, for accelerating Particle-In-Cell (PIC) codes on heterogeneous many-core architectures such as Graphic Processing Units (GPUs). The aim of this development is efficient simulations on…

Computational Physics · Physics 2016-06-08 F. Hariri , T. M. Tran , A. Jocksch , E. Lanti , J. Progsch , P. Messmer , S. Brunner , G. Gheller , L. Villard

Hierarchical matrices provide a powerful representation for significantly reducing the computational complexity associated with dense kernel matrices. For general kernel functions, interpolation-based methods are widely used for the…

Numerical Analysis · Mathematics 2022-06-07 Difeng Cai , Hua Huang , Edmond Chow , Yuanzhe Xi

General matrix-matrix multiplication (GEMM) is a cornerstone of AI computations, making tensor processing engines (TPEs) increasingly critical in GPUs and domain-specific architectures. Existing architectures primarily optimize dataflow or…

Hardware Architecture · Computer Science 2025-03-11 Qizhe Wu , Huawen Liang , Yuchen Gui , Zhichen Zeng , Zerong He , Linfeng Tao , Xiaotian Wang , Letian Zhao , Zhaoxi Zeng , Wei Yuan , Wei Wu , Xi Jin

Rapid advancements in artificial intelligence have given rise to transformative models, profoundly impacting our lives. These models demand massive volumes of data to operate effectively, exacerbating the data-transfer bottleneck inherent…

Emerging Technologies · Computer Science 2024-01-12 Zhicheng Xu , Che-Kai Liu , Chao Li , Ruibin Mao , Jianyi Yang , Thomas Kämpfe , Mohsen Imani , Can Li , Cheng Zhuo , Xunzhao Yin

Applications of Binary Neural Networks (BNNs) are promising for embedded systems with hard constraints on computing power. Contrary to conventional neural networks with the floating-point datatype, BNNs use binarized weights and activations…

Emerging Technologies · Computer Science 2022-11-14 Mahdi Zahedi , Taha Shahroodi , Stephan Wong , Said Hamdioui