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This paper presents a novel approach to neuromorphic audio processing by integrating the strengths of Spiking Neural Networks (SNNs), Transformers, and high-performance computing (HPC) into the HPCNeuroNet architecture. Utilizing the Intel…

Audio and Speech Processing · Electrical Eng. & Systems 2023-11-22 Murat Isik , Hiruna Vishwamith , Kayode Inadagbo , I. Can Dikmen

The advent of dedicated Deep Learning (DL) accelerators and neuromorphic processors has brought on new opportunities for applying both Deep and Spiking Neural Network (SNN) algorithms to healthcare and biomedical applications at the edge.…

Genomics is the critical key to enabling precision medicine, ensuring global food security and enforcing wildlife conservation. The massive genomic data produced by various genome sequencing technologies presents a significant challenge for…

Genomics · Quantitative Biology 2019-10-03 Farzaneh Zokaee , Mingzhe Zhang , Lei Jiang

A tandem cell is proposed for DNA sequencing in which an exonuclease enzyme cleaves bases (mononucleotides) from a strand of DNA for identification inside a nanopore. It has two nanopores and three compartments with the structure [cis1,…

Biomolecules · Quantitative Biology 2014-08-21 G. Sampath

Primary motivation for this work was the need to implement hardware accelerators for a newly proposed ANN structure called Auto Resonance Network (ARN) for robotic motion planning. ARN is an approximating feed-forward hierarchical and…

Neural and Evolutionary Computing · Computer Science 2024-02-02 Shilpa Mayannavar , Uday Wali

Deep learning hardware designs have been bottlenecked by conventional memories such as SRAM due to density, leakage and parallel computing challenges. Resistive devices can address the density and volatility issues, but have been limited by…

Emerging Technologies · Computer Science 2020-10-28 Shihui Yin , Xiaoyu Sun , Shimeng Yu , Jae-sun Seo

Data application developers and data scientists spend an inordinate amount of time iterating on machine learning (ML) workflows -- by modifying the data pre-processing, model training, and post-processing steps -- via trial-and-error to…

Machine Learning · Computer Science 2018-08-06 Doris Xin , Litian Ma , Jialin Liu , Stephen Macke , Shuchen Song , Aditya Parameswaran

A very robust and efficient hybrid analytic-numerical Fock build, aMECP+aCOSx, has been developed for accelerating HF/DFT calculations. The essential idea is to extract those portions of the Fock matrix that can readily be evaluated…

Chemical Physics · Physics 2024-11-05 Yong Zhang , Rongding Lei , Bingbing Suo , Wenjian Liu

The ever-increasing computation complexity of fast-growing Deep Neural Networks (DNNs) has requested new computing paradigms to overcome the memory wall in conventional Von Neumann computing architectures. The emerging Computing-In-Memory…

Hardware Architecture · Computer Science 2021-07-21 Kaining Zhou , Yangshuo He , Rui Xiao , Kejie Huang

Manufacturing-viable neuromorphic chips require novel computer architectures to achieve the massively parallel and efficient information processing the brain supports so effortlessly. Emerging event-based architectures are making this dream…

Hardware Architecture · Computer Science 2023-01-25 Lennart Bamberg , Arash Pourtaherian , Luc Waeijen , Anupam Chahar , Orlando Moreira

The rapid growth of deep neural network (DNN) workloads has significantly increased the demand for large-capacity on-chip SRAM in machine learning (ML) applications, with SRAM arrays now occupying a substantial fraction of the total die…

Hardware Architecture · Computer Science 2025-12-30 Subhradip Chakraborty , Ankur Singh , Xuming Chen , Gourav Datta , Akhilesh R. Jaiswal

Generative foundation models have become an important tool for data reconstruction and simulation in scientific computing, showing a tight integration with traditional numerical simulations. At the same time, with the development of new…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-19 Jinxiao Zhang , Yunpu Xu , Xiyong Wu , Runmin Dong , Shenggan Cheng , Yi Zhao , Mengxuan Chen , Qinrui Zheng , Jianting Liu , Haohuan Fu

In this survey paper, we have evaluated several recent deep neural network (DNN) architectures on a TIMIT phone recognition task. We chose the TIMIT corpus due to its popularity and broad availability in the community. It also simulates a…

Computation and Language · Computer Science 2018-06-22 Josef Michalek , Jan Vanek

Fully Homomorphic Encryption (FHE) imposes substantial memory bandwidth demands, presenting significant challenges for efficient hardware acceleration. Near-memory Processing (NMP) has emerged as a promising architectural solution to…

Hardware Architecture · Computer Science 2025-04-01 Shangyi Shi , Husheng Han , Jianan Mu , Xinyao Zheng , Ling Liang , Hang Lu , Zidong Du , Xiaowei Li , Xing Hu , Qi Guo

The proliferation of high-throughput sequencing machines ensures rapid generation of up to billions of short nucleotide fragments in a short period of time. This massive amount of sequence data can quickly overwhelm today's storage and…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-11-13 Subho S. Banerjee , Mohamed El-Hadedy , Jong Bin Lim , Zbigniew T. Kalbarczyk , Deming Chen , Steve Lumetta , Ravishankar K. Iyer

High-performance computing systems are moving towards 2.5D and 3D memory hierarchies, based on High Bandwidth Memory (HBM) and Hybrid Memory Cube (HMC) to mitigate the main memory bottlenecks. This trend is also creating new opportunities…

Hardware Architecture · Computer Science 2017-09-26 Erfan Azarkhish , Davide Rossi , Igor Loi , Luca Benini

We develop a new class of genetic algorithm that computationally determines efficient pulse sequences to implement a quantum gate U in a three-qubit system. The method is shown to be quite general, and the same algorithm can be used to…

Quantum Physics · Physics 2009-12-04 Ashok Ajoy , Anil Kumar

The Mixture-of-Experts (MoE) models have emerged as the state-of-the-art paradigm for scaling up large language models (LLMs) without proportionally increased computational cost. However, its on-device deployment faces a critical challenge…

Hardware Architecture · Computer Science 2026-05-25 Weikai Xu , Meng Li , Shuzhang Zhong , Tianyang Luo , Dongxue Zhao , Ling Liang , Zongwei Wang , Qianqian Huang , Yimao Cai , Ru Huang

Decoder-only Transformer models such as GPT have demonstrated exceptional performance in text generation, by autoregressively predicting the next token. However, the efficacy of running GPT on current hardware systems is bounded by low…

Hardware Architecture · Computer Science 2024-04-16 Yuting Wu , Ziyu Wang , Wei D. Lu

High-performance computing underpins modern artificial intelligence (AI), enabling foundation models, real-time inference and perception in autonomous systems, and data-intensive scientific simulations. Recent advances in quantization…