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Brain tumor segmentation is one of the most challenging problems in medical image analysis. The goal of brain tumor segmentation is to generate accurate delineation of brain tumor regions. In recent years, deep learning methods have shown…

Image and Video Processing · Electrical Eng. & Systems 2021-11-18 Zhihua Liu , Lei Tong , Zheheng Jiang , Long Chen , Feixiang Zhou , Qianni Zhang , Xiangrong Zhang , Yaochu Jin , Huiyu Zhou

Due to their increasing spread, confidence in neural network predictions became more and more important. However, basic neural networks do not deliver certainty estimates or suffer from over or under confidence. Many researchers have been…

Medical Image Foundation Models have proven to be powerful tools for mask prediction across various datasets. However, accurately assessing the uncertainty of their predictions remains a significant challenge. To address this, we propose a…

Image and Video Processing · Electrical Eng. & Systems 2025-01-20 Xin Wang , Xiaoyu Liu , Peng Huang , Pu Huang , Shu Hu , Hongtu Zhu

Medical image segmentation modeling is a high-stakes task where understanding of uncertainty is crucial for addressing visual ambiguity. Prior work has developed segmentation models utilizing probabilistic or generative mechanisms to infer…

Computer Vision and Pattern Recognition · Computer Science 2025-06-13 Andre Ye , Quan Ze Chen , Amy Zhang

Manual segmentation is used as the gold-standard for evaluating neural networks on automated image segmentation tasks. Due to considerable heterogeneity in shapes, colours and textures, demarcating object boundaries is particularly…

Image and Video Processing · Electrical Eng. & Systems 2021-11-02 Michael Yeung , Guang Yang , Evis Sala , Carola-Bibiane Schönlieb , Leonardo Rundo

Quantitative characterizations and estimations of uncertainty are of fundamental importance in optimization and decision-making processes. Herein, we propose intuitive scores, which we call certainty and doubt, that can be used in both a…

Performance metrics for medical image segmentation models are used to measure the agreement between the reference annotation and the predicted segmentation. Usually, overlap metrics, such as the Dice, are used as a metric to evaluate the…

Image and Video Processing · Electrical Eng. & Systems 2024-03-26 Sophie Ostmeier , Brian Axelrod , Jeroen Bertels , Fabian Isensee , Maarten G. Lansberg , Soren Christensen , Gregory W. Albers , Li-Jia Li , Jeremy J. Heit

Brain tumors, particularly gliomas, pose significant chall-enges due to their complex growth patterns, infiltrative nature, and the variability in brain structure across individuals, which makes accurate diagnosis and monitoring difficult.…

Glioma is the most deadly brain tumor with high mortality. Treatment planning by human experts depends on the proper diagnosis of physical symptoms along with Magnetic Resonance(MR) image analysis. Highly variability of a brain tumor in…

Image and Video Processing · Electrical Eng. & Systems 2021-03-09 Rupal Agravat , Mehul S Raval

Uncertainty estimation is important for ensuring safety and robustness of AI systems. While most research in the area has focused on un-structured prediction tasks, limited work has investigated general uncertainty estimation approaches for…

Machine Learning · Statistics 2021-02-12 Andrey Malinin , Mark Gales

Reliable tumor segmentation in thoracic computed tomography (CT) remains challenging due to boundary ambiguity, class imbalance, and anatomical variability. We propose an uncertainty-guided, coarse-to-fine segmentation framework that…

Computer Vision and Pattern Recognition · Computer Science 2025-07-04 Ilkin Sevgi Isler , David Mohaisen , Curtis Lisle , Damla Turgut , Ulas Bagci

This paper explores uncertainty quantification (UQ) as an indicator of the trustworthiness of automated deep-learning (DL) tools in the context of white matter lesion (WML) segmentation from magnetic resonance imaging (MRI) scans of…

Neural cellular automata (NCA) provide a lightweight alternative to encoder-decoder segmentation networks. However, it can be difficult to decide when a prediction should be trusted. Here, we study uncertainty estimation for NCA-based…

Image and Video Processing · Electrical Eng. & Systems 2026-05-27 Ario Sadafi , Michael Deutges , Nassir Navab , Carsten Marr

The diagnosis of brain tumours is an extremely sensitive and complex clinical task that must rely upon information gathered through non-invasive techniques. One such technique is magnetic resonance, in the modalities of imaging or…

Image and Video Processing · Electrical Eng. & Systems 2025-03-13 Carlos Arizmendi , Alfredo Vellido , Enrique Romero

In machine learning, accurately predicting the probability that a specific input is correct is crucial for risk management. This process, known as uncertainty (or confidence) estimation, is particularly important in mission-critical…

Machine Learning · Computer Science 2023-01-12 Gabriella Chouraqui , Liron Cohen , Gil Einziger , Liel Leman

Deep learning-based brain tumor segmentation (BTS) models for multi-modal MRI images have seen significant advancements in recent years. However, a common problem in practice is the unavailability of some modalities due to varying scanning…

Computer Vision and Pattern Recognition · Computer Science 2024-06-17 Weide Liu , Jingwen Hou , Xiaoyang Zhong , Huijing Zhan , Jun Cheng , Yuming Fang , Guanghui Yue

Reliable uncertainty quantification is a first step towards building explainable, transparent, and accountable artificial intelligent systems. Recent progress in Bayesian deep learning has made such quantification realizable. In this paper,…

Computation and Language · Computer Science 2018-11-20 Yijun Xiao , William Yang Wang

Neoadjuvant therapy (NAT) for breast cancer is a common treatment option in clinical practice. Tumor cellularity (TC), which represents the percentage of invasive tumors in the tumor bed, has been widely used to quantify the response of…

Image and Video Processing · Electrical Eng. & Systems 2022-06-15 Xiangyu Li , Xinjie Liang , Gongning Luo , Wei Wang , Kuanquan Wang , Shuo Li

Uncertainty estimation bears the potential to make deep learning (DL) systems more reliable. Standard techniques for uncertainty estimation, however, come along with specific combinations of strengths and weaknesses, e.g., with respect to…

Machine Learning · Computer Science 2022-05-02 Joachim Sicking , Maram Akila , Jan David Schneider , Fabian Hüger , Peter Schlicht , Tim Wirtz , Stefan Wrobel

Breast cancer is a heterogeneous disease with different molecular subtypes, clinical behavior, treatment responses as well as survival outcomes. The development of a reliable, accurate, available and inexpensive method to predict the…

Computer Vision and Pattern Recognition · Computer Science 2024-12-20 Mohaddeseh Chegini , Ali Mahloojifar