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Proper quantification of predictive uncertainty is essential for the use of machine learning in safety-critical applications. Various uncertainty measures have been proposed for this purpose, typically claiming superiority over other…

Machine Learning · Computer Science 2025-12-16 Paul Hofman , Yusuf Sale , Eyke Hüllermeier

Despite the state-of-the-art performance for medical image segmentation, deep convolutional neural networks (CNNs) have rarely provided uncertainty estimations regarding their segmentation outputs, e.g., model (epistemic) and image-based…

Computer Vision and Pattern Recognition · Computer Science 2019-02-12 Guotai Wang , Wenqi Li , Michael Aertsen , Jan Deprest , Sebastien Ourselin , Tom Vercauteren

We address the problem of uncertainty quantification and propose measures of total, aleatoric, and epistemic uncertainty based on a known decomposition of (strictly) proper scoring rules, a specific type of loss function, into a divergence…

Machine Learning · Computer Science 2025-05-29 Paul Hofman , Yusuf Sale , Eyke Hüllermeier

Uncertainty quantification (UQ) has become critical for evaluating the reliability of artificial intelligence systems, especially in medical image segmentation. This study addresses the interpretability of instance-wise uncertainty values…

Multi-contrast magnetic resonance imaging (MRI) plays a vital role in brain tumor segmentation and diagnosis by leveraging complementary information from different contrasts. Each contrast highlights specific tumor characteristics, enabling…

Image and Video Processing · Electrical Eng. & Systems 2025-03-10 Zhenxuan Zhang , Hongjie Wu , Jiahao Huang , Baihong Xie , Zhifan Gao , Junxian Du , Pete Lally , Guang Yang

Precise segmentation of a lesion area is important for optimizing its treatment. Deep learning makes it possible to detect and segment a lesion field using annotated data. However, obtaining precisely annotated data is very challenging in…

Computer Vision and Pattern Recognition · Computer Science 2021-02-02 Ling Huang , Su Ruan , Thierry Denoeux

Brain tumour segmentation is an essential task in medical image processing. Early diagnosis of brain tumours plays a crucial role in improving treatment possibilities and increases the survival rate of the patients. Manual segmentation of…

Image and Video Processing · Electrical Eng. & Systems 2021-11-08 Angad Ripudaman Singh Bajwa

Uncertainty quantification in automated image analysis is highly desired in many applications. Typically, machine learning models in classification or segmentation are only developed to provide binary answers; however, quantifying the…

Brain tumor analysis in MRI images is a significant and challenging issue because misdiagnosis can lead to death. Diagnosis and evaluation of brain tumors in the early stages increase the probability of successful treatment. However, the…

Image and Video Processing · Electrical Eng. & Systems 2021-12-30 Zahra Sobhaninia , Nader Karimi , Pejman Khadivi , Shadrokh Samavi

The complex heterogeneity of brain tumours is increasingly recognized to demand data of magnitudes and richness only fully-inclusive, large-scale collections drawn from routine clinical care could plausibly offer. This is a task…

Computer Vision and Pattern Recognition · Computer Science 2023-05-01 James K Ruffle , Samia Mohinta , Robert J Gray , Harpreet Hyare , Parashkev Nachev

Accurately segmenting brain tumors from MRI scans is important for developing effective treatment plans and improving patient outcomes. This study introduces a new implementation of the Columbia-University-Net (CU-Net) architecture for…

Computer Vision and Pattern Recognition · Computer Science 2024-06-21 Qimin Zhang , Weiwei Qi , Huili Zheng , Xinyu Shen

Automatic brain tumor segmentation plays an important role for diagnosis, surgical planning and treatment assessment of brain tumors. Deep convolutional neural networks (CNNs) have been widely used for this task. Due to the relatively small…

Computer Vision and Pattern Recognition · Computer Science 2019-02-26 Guotai Wang , Wenqi Li , Sebastien Ourselin , Tom Vercauteren

Prediction uncertainty estimation has clinical significance as it can potentially quantify prediction reliability. Clinicians may trust 'blackbox' models more if robust reliability information is available, which may lead to more models…

Machine Learning · Computer Science 2022-10-04 Michael Dohopolski , Kai Wang , Biling Wang , Ti Bai , Dan Nguyen , David Sher , Steve Jiang , Jing Wang

Uncertainty quantification is necessary for developers, physicians, and regulatory agencies to build trust in machine learning predictors and improve patient care. Beyond measuring uncertainty, it is crucial to express it in clinically…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Jacopo Teneggi , J Webster Stayman , Jeremias Sulam

Advances in computing technology have allowed researchers across many fields of endeavor to collect and maintain vast amounts of observational statistical data such as clinical data, biological patient data, data regarding access of web…

Computer Vision and Pattern Recognition · Computer Science 2014-01-24 Narkhede Sachin G , Vaishali Khairnar

In this PhD thesis, we propose a novel framework for uncertainty quantification in machine learning, which is based on proper scores. Uncertainty quantification is an important cornerstone for trustworthy and reliable machine learning…

Machine Learning · Computer Science 2025-08-26 Sebastian G. Gruber

This paper proposes a novel approach for uncertainty quantification in dense Conditional Random Fields (CRFs). The presented approach, called Perturb-and-MPM, enables efficient, approximate sampling from dense multi-label CRFs via random…

Computer Vision and Pattern Recognition · Computer Science 2017-03-03 Raphael Meier , Urspeter Knecht , Alain Jungo , Roland Wiest , Mauricio Reyes

Early detection and quantification of tumour growth would help clinicians to prescribe more accurate treatments and provide better surgical planning. However, the multifactorial and heterogeneous nature of lung tumour progression hampers…

Computer Vision and Pattern Recognition · Computer Science 2021-04-20 Xavier Rafael-Palou , Anton Aubanell , Mario Ceresa , Vicent Ribas , Gemma Piella , Miguel A. González Ballester

In this work, we describe a Bayesian framework for reconstructing the boundaries of piecewise smooth regions in the X-ray computed tomography (CT) problem in an infinite-dimensional setting. In addition to the reconstruction, we are also…

Numerical Analysis · Mathematics 2022-12-20 Babak Maboudi Afkham , Yiqiu Dong , Per Christian Hansen

Recently deep learning has been playing a major role in the field of computer vision. One of its applications is the reduction of human judgment in the diagnosis of diseases. Especially, brain tumor diagnosis requires high accuracy, where…

Computer Vision and Pattern Recognition · Computer Science 2018-09-24 Zahra Sobhaninia , Safiyeh Rezaei , Alireza Noroozi , Mehdi Ahmadi , Hamidreza Zarrabi , Nader Karimi , Ali Emami , Shadrokh Samavi