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Pulmonary arterial hypertension (PAH) is a progressive cardiopulmonary disease that leads to increased pulmonary pressures, vascular remodeling, and eventual right ventricular (RV) failure. Pediatric PAH remains understudied due to limited…
Dementia affects cognitive functions of adults, including memory, language, and behaviour. Standard diagnostic biomarkers such as MRI are costly, whilst neuropsychological tests suffer from sensitivity issues in detecting dementia onset.…
Atrial fibrillation is increasingly prevalent, especially in the elderly, and challenging to detect due paroxysmal nature. Here, we propose novel computational methods based on heart beat intervals to facilitate rapid and robust…
Ischemic heart disease (IHD), particularly in its chronic stable form, is a subtle pathology due to its silent behavior before developing in unstable angina, myocardial infarction or sudden cardiac death. Machine learning techniques applied…
This paper proposes a prototype of a new biofeedback training based on mathematical models of cardiovascular control. For this purpose we develop a low-cost device that is able to record and process arterial pulse wave via…
Notwithstanding the significant efforts to develop estimators of long-range correlations (LRC) and to compare their performance, no clear consensus exists on what is the best method and under which conditions. In addition, synthetic tests…
This paper considers the practically important case of nonparametrically estimating heterogeneous average treatment effects that vary with a limited number of discrete and continuous covariates in a selection-on-observables framework where…
Aims. Clinical data indicating a heart rate (HR) target during rate control therapy for permanent atrial fibrillation (AF) and assessing its eventual relationship with reduced exercise tolerance are lacking. The present study aims at…
Photoplethysmography (PPG) sensors allow for non-invasive and comfortable heart-rate (HR) monitoring, suitable for compact wrist-worn devices. Unfortunately, Motion Artifacts (MAs) severely impact the monitoring accuracy, causing high…
We present algorithms for nonparametric regression in settings where the data are obtained sequentially. While traditional estimators select bandwidths that depend upon the sample size, for sequential data the effective sample size is…
Statistically simulated time series of wave parameters are required for many coastal and offshore engineering applications, often at the resolution of approximately one hour. Various studies have relied on autoregressive moving-average…
Transcranial Magnetic Stimulation (TMS) combined with EEG recordings (TMS-EEG) has shown great potential in the study of the brain and in particular of Alzheimer's Disease (AD). In this study, we propose an automatic method of determining…
Heart Rate Variability (HRV) measures the variation of the time between consecutive heartbeats and is a major indicator of physical and mental health. Recent research has demonstrated that photoplethysmography (PPG) sensors can be used to…
The attention for personalized mental health care is thriving. Research data specific to the individual, such as time series sensor data or data from intensive longitudinal studies, is relevant from a research perspective, as analyses on…
Nonparametric estimation of the mean and covariance functions is ubiquitous in functional data analysis and local linear smoothing techniques are most frequently used. Zhang and Wang (2016) explored different types of asymptotic properties…
An efficient estimator is constructed for the quadratic covariation or integrated co-volatility matrix of a multivariate continuous martingale based on noisy and nonsynchronous observations under high-frequency asymptotics. Our approach…
Quantitative characterization of disease progression using longitudinal data can provide long-term predictions for the pathological stages of individuals. This work studies the robust modeling of Alzheimer's disease progression using…
Repeated observations have become increasingly common in biomedical research and longitudinal studies. For instance, wearable sensor devices are deployed to continuously track physiological and biological signals from each individual over…
Marginal structural models are a popular method for estimating causal effects in the presence of time-varying exposures. In spite of their popularity, no scalable non-parametric estimator exist for marginal structural models with…
The use of spontaneous language to derive appropriate digital markers has become an emergent, promising and non-intrusive method to diagnose and monitor dementia. Here we propose methods to capture language coherence as a cost-effective,…