Related papers: Algorithm for Optimized mRNA Design Improves Stabi…
In this paper we study irreducibility in RNA structures. By RNA structure we mean RNA secondary as well as RNA pseudoknot structures. In our analysis we shall contrast random and minimum free energy (mfe) configurations. We compute various…
Proteins can exhibit dynamic structural flexibility as they carry out their functions, especially in binding regions that interact with other molecules. For the key SARS-CoV-2 spike protein that facilitates COVID-19 infection, studies have…
Antibodies are crucial proteins produced by the immune system in response to foreign substances or antigens. The specificity of an antibody is determined by its complementarity-determining regions (CDRs), which are located in the variable…
Patients with motor control difficulties often "type" on a computer using a switch keyboard to guide a scanning cursor to text elements. We show how to optimize some parts of the design of switch keyboards by casting the design problem as…
mRNA-based vaccines have become a major focus in the pharmaceutical industry. The coding sequence as well as the Untranslated Regions (UTRs) of an mRNA can strongly influence translation efficiency, stability, degradation, and other factors…
Antibodies are versatile proteins that can bind to pathogens and provide effective protection for human body. Recently, deep learning-based computational antibody design has attracted popular attention since it automatically mines the…
The rapid evolution of wireless technologies necessitates automated design frameworks to address antenna miniaturization and performance optimization within constrained development cycles. This study demonstrates a machine learning enhanced…
To improve signal-to-interference ratio (SIR) and make better use of file diversity provided by random caching, we consider two types of linear receivers, i.e., maximal ratio combining (MRC) receiver and partial zero forcing (PZF) receiver,…
Accurate RNA structure modeling remains difficult because RNA backbones are highly flexible, non-canonical interactions are prevalent, and experimentally determined 3D structures are comparatively scarce. We introduce \emph{RiboSphere}, a…
Implantable Brain-machine interfaces (BMIs) are promising for motor rehabilitation and mobility augmentation, and they demand accurate and energy-efficient algorithms. In this paper, we propose a novel spiking neural network (SNN) decoder…
This paper presents an automated antenna design and optimization framework employing multi-objective genetic algorithms (MOGAs) to investigate various evolutionary optimization approaches, with a primary emphasis on multi-band frequency…
Motivation: Non-coding RNAs (ncRNAs) express their functions by adopting molecular structures. Specifically, RNA secondary structures serve as a relatively stable intermediate step before tertiary structures, offering a reliable signature…
Several novel industrial applications involve human control of vehicles, cranes, or mobile robots through various high-throughput feedback systems, such as Virtual Reality (VR) and tactile/haptic signals. The near real-time interaction…
In this paper, a downlink multiple input multiple output (MIMO) non-orthogonal multiple access (NOMA) wireless communication system is considered. In NOMA systems, the base station has unicast data for all users, and multiple users in a…
Matrix-based optimizers have demonstrated immense potential in training Large Language Models (LLMs), however, designing an ideal optimizer remains a formidable challenge. A superior optimizer must satisfy three core desiderata: efficiency,…
In this paper two formulations for the robust optimization of the size of the permanent magnet in a synchronous machine are discussed. The optimization is constrained by a partial differential equation to describe the electromagnetic…
In this paper, we consider linear precoding with SINR constraints for the downlink of a multiuser MISO (multiple-input single-output) communication system in the presence of imperfect channel state information (CSI). The base station is…
Magnetic resonance (MR) fingerprinting is a new quantitative imaging paradigm, which simultaneously acquires multiple MR tissue parameter maps in a single experiment. In this paper, we present an estimation-theoretic framework to perform…
The rapidly advancing fields of statistical modeling and machine learning have significantly enhanced data-driven design and optimization. This paper focuses on leveraging these design algorithms to optimize a medical walker, an integral…
In Near Memory Processing (NMP), processing elements(PEs) are placed near the 3D memory, reducing unnecessary data transfers between the CPU and the memory. However, as the CPUs and the PEs of the NMP use a shared memory space, maintaining…