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Proteins are macromolecules that perform essential functions in all living organisms. Designing novel proteins with specific structures and desired functions has been a long-standing challenge in the field of bioengineering. Existing…
The US FDA's Project Optimus initiative that emphasizes dose optimization prior to marketing approval represents a pivotal shift in oncology drug development. It has a ripple effect for rethinking what changes may be made to conventional…
We study the stability of wireless networks under stochastic arrival processes of packets, and design efficient, distributed algorithms that achieve stability in the SINR (Signal to Interference and Noise Ratio) interference model.…
Survival analysis, the art of time-to-event modeling, plays an important role in clinical treatment decisions. Recently, continuous time models built from neural ODEs have been proposed for survival analysis. However, the training of neural…
We study the use of "sign $\alpha$-stable random projections" (where $0<\alpha\leq 2$) for building basic data processing tools in the context of large-scale machine learning applications (e.g., classification, regression, clustering, and…
A permanent magnet array (PMA) is a preferred source of magnetic field for body-part-dedicated low-field (<0.5 T) portable magnetic resonance imaging (MRI) because it has a small footprint, no power consumption, and no need for a cooling…
In neural circuits, recurrent connectivity plays a crucial role in network function and stability. However, existing recurrent spiking neural networks (RSNNs) are often constructed by random connections without optimization. While RSNNs can…
Random Linear Network Coding (RLNC) has emerged as a powerful tool for robust high-throughput multicast. Projection analysis - a recently introduced technique - shows that the distributed packetized RLNC protocol achieves (order) optimal…
For many next-generation high intensity proton accelerator applications including the Spallation Neutron Source (SNS), superconducting (SC) RF provides the technology of choice for the linac. In designing the superconducting cavity, several…
Spiking Neural Networks (SNNs) can offer ultra-low power/energy consumption for machine learning-based application tasks due to their sparse spike-based operations. Currently, most of the SNN architectures need a significantly larger model…
The success of deep learning in the past decade is partially shrouded in the shadow of adversarial attacks. In contrast, the brain is far more robust at complex cognitive tasks. Utilizing the advantage that neurons in the brain communicate…
Two-dimensional, resonant scanners have been utilized in a large variety of imaging modules due to their compact form, low power consumption, large angular range, and high speed. However, resonant scanners have problems with non-optimal and…
We consider the downlink of a single-cell multi-user MIMO system in which the base station makes use of $N$ antennas to communicate with $K$ single-antenna user equipments (UEs) randomly positioned in the coverage area. In particular, we…
Applications in machine learning, optimization, and control require the sequential selection of a few system elements, such as sensors, data, or actuators, to optimize the system performance across multiple time steps. However, in…
A general method for obtaining highly efficient factorial designs of relatively small sizes is developed for cDNA microarray experiments. The method allows the main effects and interactions of successive orders to be of possibly unequal…
Recent advances have shown that SNN-based systems can efficiently perform unsupervised continual learning due to their bio-plausible learning rule, e.g., Spike-Timing-Dependent Plasticity (STDP). Such learning capabilities are especially…
We introduce RosettaSearch, an inference-time multi-objective optimization approach for backbone conditioned protein sequence design. We use large language models (LLMs) as a generative optimizer within a search algorithm capable of…
The protein design problem involves finding polypeptide sequences folding into a given threedimensional structure. Its rigorous algorithmic solution is computationally demanding, involving a nested search in sequence and structure spaces.…
Spiking neural networks have gained significant attention due to their brain-like information processing capabilities. The use of surrogate gradients has made it possible to train spiking neural networks with backpropagation, leading to…
Over the brief time intervals available for processing retinal output, roughly 50 to 300 msec, the number of extra spikes generated by individual ganglion cells can be quite variable. Here, computer-generated spike trains were used to…