Related papers: Cahn-Hilliard-Brinkman systems for tumour growth
In this paper we present a method for estimating unknown parameters that appear on an avascular, spheric tumour growth model. The model for the tumour is based on nutrient driven growth of a continuum of live cells, whose birth and death…
The phase separation of an isothermal incompressible binary fluid in a porous medium can be described by the so-called Brinkman equation coupled with a convective Cahn-Hilliard (CH) equation. The former governs the average fluid velocity…
We introduce a multi-species diffuse interface model for tumor growth, characterized by its incorporation of essential features related to chemotaxis, angiogenesis and proliferation mechanisms. We establish the weak well-posedness of the…
In this manuscript, we study a nonlinear model of tumor growth, described by a coupled hyperbolic-elliptic system of partial differential equations. In this model, the compressible flow of tumor cells is modeled by a transport equation for…
In this work, we study a phase-field model for curvature-driven pattern formation in biomembranes. The model is derived as a gradient flow of an energy functional that approximates the two-phase Canham--Helfrich energy. This leads to a…
We investigate a new diffuse-interface model that describes creeping two-phase flows (i.e., flows exhibiting a low Reynolds number), especially flows that permeate a porous medium. The system of equations consists of a Brinkman equation for…
Tumor growth has a number of features in common with a physical process known as molecular beam epitaxy. Both growth processes are characterized by the constraint of growth development to the body border, and surface diffusion of…
Free boundaries of biofilms advancing on surfaces evolve according to conservation laws coupled with systems of partial differential equations for velocities, pressures and chemicals affecting cell behavior. Thin film approximations lead to…
We propose a model for describing the growth on an untreated tumor, which is characterized in a simple way by a minimal number of parameters with a well-defined physical interpretation. The model is motivated by invoking the Master Equation…
Microscale oxygenation plays a prominent role in tumour progression. Spatiotemporal variability of oxygen distribution in the tumour microenvironment contributes to cellular heterogeneity and to the emergence of normoxic and hypoxic…
We study the well-posedness of a modified degenerate Cahn-Hilliard type model for surface diffusion. With degenerate phase-dependent diffusion mobility and additional stabilizing function, this model is able to give the correct sharp…
In this paper, we propose a tumor growth model to incorporate and investigate the spatial effects of autophagy. The cells are classified into two phases: normal cells and autophagic cells, whose dynamics are also coupled with the nutrients.…
In this study, we model avascular tumour growth in epithelial tissue. This can help us to get a macroscopic view of the interaction between the tumour with its surrounding microenvironment and the physical changes within the tumour…
Phase field models frequently provide insight to phase transitions, and are robust numerical tools to solve free boundary problems corresponding to the motion of interfaces. A body of prior literature suggests that interface motion via…
The Cahn-Hilliard equation is a fundamental model for phase separation phenomena. Its rigorous derivation from the nonlocal aggregation equation, motivated by the desire to link interacting particle systems and continuous descriptions, has…
This paper tackles the approximation of surface diffusion flow using a Cahn--Hilliard-type model. We introduce and analyze a new second order variational phase field model which associates the classical Cahn--Hilliard energy with two…
The Cahn-Hilliard model with reaction terms can lead to situations in which no coarsening is taking place and, in contrast, growth and division of droplets occur which all do not grow larger than a certain size. This phenomenon has been…
We derive a class of Navier--Stokes--Cahn--Hilliard systems that models two-phase flows with mass transfer coupled to the process of chemotaxis. These thermodynamically consistent models can be seen as the natural Navier--Stokes analogues…
In this paper, we studied phase-space analysis of a certain mathematical model of tumor growth with an immune responses and chemotherapy therapy. Mathematical modelling of this process is viewed as a potentially powerful tool in the…
Cancer is a very complex phenomenon that involves many different scales and situations. In this paper we consider a free boundary problem describing the evolution of a tumor colony and we derive a new asymptotic model for tumor growth. We…