Related papers: Cahn-Hilliard-Brinkman systems for tumour growth
Cancer is a disease that takes millions of lives every year. Then, to propose treatments, avoid recurrence, and improve the patient's life quality, we need to analyze this disease from a biophysical perspective with a solid mathematical…
Initiation and development of a malignant tumor is a complex phenomenon that has critical stages determining its long time behavior. This phenomenon is mathematically described by means of various models: from simple heuristic models to…
We investigate the dynamics of a nonlinear model for tumor growth within a cellular medium. In this setting the "tumor" is viewed as a multiphase flow consisting of cancerous cells in either proliferating phase or quiescent phase and a…
We prove existence of weak solutions and weak-strong uniqueness for a mathematical model which couples the evolution of a phase-parameter $\varphi$ satisfying a Cahn-Hilliard type relation with the one of an additional variable $\sigma$…
In this work we study a tissue growth model with applications to tumour growth. The model is based on that of Perthame, Quir\'os, and V\'azquez proposed in 2014 but incorporates the advective effects caused, for instance, by the presence of…
In the present article the diffusion equation is used to model the spatio-temporal dynamics of a tumor, taking into account the heterogeneous of the medium. This approach makes it possible to take into account the complex geometric shape of…
We investigate the long-time dynamics and optimal control problem of a diffuse interface model that describes the growth of a tumor in presence of a nutrient and surrounded by host tissues. The state system consists of a Cahn-Hilliard type…
We propose a new type of diffuse interface model describing the evolution of a tumor mass under the effects of a chemical substance (e.g., a nutrient or a drug). The process is described by utilizing the variables $\varphi$, an order…
We develop a field theory-inspired stochastic model for description of tumour growth based on an analogy with an SI epidemic model, where the susceptible individuals (S) would represent the healthy cells and the infected ones (I), the…
In this paper, a distributed optimal control problem is studied for a diffuse interface model of tumor growth which was proposed in [A. Hawkins-Daruud, K.G. van der Zee, J.T. Oden, Numerical simulation of a thermodynamically consistent…
We consider a model describing the evolution of a tumor inside a host tissue in terms of the parameters $\varphi_p$, $\varphi_d$ (proliferating and dead cells, respectively), $u$ (cell velocity) and $n$ (nutrient concentration). The…
In this paper, a two-dimensional model for the growth of multi-layer tumors is presented. The model consists of a free boundary problem for the tumor cell membrane and the tumor is supposed to grow or shrink due to cell proliferation or…
We present a two-dimensional continuum model of tumor growth, which treats the tissue as a composition of six distinct fluid phases; their dynamics are governed by the equations of mass and momentum conservation. Our model divides the…
Using formal asymptotic methods we derive a free boundary problem representing one of the simplest mathematical descriptions of the growth and death of a tumour or other biological tissue. The mathematical model takes the form of a closed…
A nutrient-limited model for avascular cancer growth including cell proliferation, motility and death is presented. The model qualitatively reproduces commonly observed morphologies for primary tumors, and the simulated patterns are…
We propose a dynamical system of tumor cells proliferation based on operatorial methods. The approach we propose is quantum-like: we use ladder and number operators to describe healthy and tumor cells birth and death, and the evolution is…
In this work, a ternary phase-field model for two-phase flows in complex geometries is proposed. In this model, one of the three components in the classical ternary Cahn-Hilliard model is considered as the solid phase, and only one…
In this paper we report on 2D numerical simulations concerning linear and nonlinear evolution of surface-tension-driven instability in two-fluid systems heated from below using classical and phase-field models. In the phase-field formalism,…
In this paper we study a non-local Cahn-Hilliard equation with singular single-well potential and degenerate mobility. This results as a particular case of a more general model derived for a binary, saturated, closed and incompressible…
We present a phase-space analysis of a mathematical model of tumor growth with an immune responses. We consider mathematical analysis of the model equations with multipoint initial condition regarding to dissipativity, boundedness of…