Related papers: Cahn-Hilliard-Brinkman systems for tumour growth
In this paper we study the rigorous sharp interface limit of a diffuse interface model related to the dynamics of tumor growth, when a parameter $\epsilon$, representing the interface thickness between the tumorous and non tumorous cells,…
In this paper we present a mathematical model to describe the phenomenon of phase separation, which is modelled as space regions where an order parameter changes smoothly. The model proposed, including thermal and mixing effects, is deduced…
We give a very short introduction to discrete and continuum models for the evolutionary and spatial dynamics of cancer through two case studies: a model for the evolutionary dynamics of cancer cells under cytotoxic therapy and a model for…
We analyze a Navier-Stokes-Cahn-Hilliard model for viscous incompressible two-phase flows where the mechanisms of chemotaxis, active transport and reaction are taken into account. The evolution system couples the Navier-Stokes equations for…
In this paper, we study an optimal control problem for a macroscopic mechanical tumour model based on the phase field approach. The model couples a Cahn--Hilliard type equation to a system of linear elasticity and a reaction-diffusion…
We analyze a coupled Cahn-Hilliard-Forchheimer system featuring concentration-dependent mobility, mass source and convective transport. The velocity field is governed by a generalized quasi-incompressible Forchheimer equation with…
In cancer, treatment failure and disease recurrence have been associated with small subpopulations of cancer cells with a stem-like phenotype. In this paper, we develop and investigate a phenotype-structured model of solid tumour growth in…
In this work, we investigate a distributed optimal control problem for an extended phase field system of Cahn--Hilliard type which physical context is that of tumor growth dynamics. In a previous contribution, the author has already studied…
In this paper, we study the longtime asymptotic behavior of a phase separation process occurring in a three-dimensional domain containing a fluid flow of given velocity. This process is modeled by a viscous convective Cahn-Hilliard system,…
The inverse geometric approach to the modeling of the growth of circular objects revealing required features, such as the velocity of the growth and fractal behavior of their contours, is presented. It enables to reproduce some of the…
Making sense of complex inhomogeneous systems composed of many interacting species is a grand challenge that pervades basically all natural sciences. Phase separation and pattern formation in reaction-diffusion systems have been largely…
The link between compressible models of tissue growth and the Hele-Shaw free boundary problem of fluid mechanics has recently attracted a lot of attention. In most of these models, only repulsive forces and advection terms are taken into…
Models of tissue growth are now well established, in particular in relation to their applications to cancer. They describe the dynamics of cells subject to motion resulting from a pressure gradient generated by the death and birth of cells,…
We consider two-phase fluid deformable surfaces as model systems for biomembranes. Such surfaces are modeled by incompressible surface Navier-Stokes-Cahn-Hilliard-like equations with bending forces. We derive this model using the…
The Rayleigh--Taylor instability of two immiscible fluids in the limit of small Atwood numbers is studied by means of a phase-field description. In this method the sharp fluid interface is replaced by a thin, yet finite, transition layer…
In this work we investigate a mathematical model describing tumour growth under a treatment by chemotherapy that incorporates time-delay related to the conversion from resting to hunting cells. We study the model using values for the…
The Cahn--Hilliard equation is one of the most common models to describe phase separation processes of a mixture of two materials. For a better description of short-range interactions between the material and the boundary, various dynamic…
In this paper we study a model describing the growth of necrotic tumors in different regimes of vascularisation. The tumor consists of a necrotic core of death cells and a surrounding nonnecrotic shell. The corresponding mathematical…
We study the long-time dynamics of a bulk-surface convective Cahn--Hilliard system describing phase separation processes with bulk-surface interaction. The presence of convection terms leads to a non-autonomous dynamical system and prevents…
A thermodynamically consistent framework able to model either diffusive and displacive phase transitions is proposed. The first law of thermodynamics, the balance of linear momentum equation and the Cahn-Hilliard equation for solute mass…