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Recent advances in single cell sequencing and multi-omics techniques have significantly improved our understanding of biological phenomena and our capacity to model them. Despite combined capture of data modalities showing similar progress,…

Molecular Networks · Quantitative Biology 2025-03-13 Marcello Barylli , Joyaditya Saha , Tineke E. Buffart , Jan Koster , Kristiaan J. Lenos , Louis Vermeulen , Vivek M. Sheraton

Many neuroscientific applications require robust and accurate localization of neurons. It is still an unsolved problem because of the enormous variation in intensity, texture, spatial overlap, morphology and background artifacts. In…

Quantitative Methods · Quantitative Biology 2021-03-22 Tamal Batabyal , Aijaz Ahmad Naik , Daniel Weller , Jaideep Kapur

Autoencoders are techniques for data representation learning based on artificial neural networks. Differently to other feature learning methods which may be focused on finding specific transformations of the feature space, they can be…

Machine Learning · Computer Science 2020-05-12 David Charte , Francisco Charte , María J. del Jesus , Francisco Herrera

Recent advances in deep learning have enabled the development of automated frameworks for analysing medical images and signals, including analysis of cervical cancer. Many previous works focus on the analysis of isolated cervical cells, or…

Computer Vision and Pattern Recognition · Computer Science 2024-03-06 Ruiqi Wang , Mohammad Ali Armin , Simon Denman , Lars Petersson , David Ahmedt-Aristizabal

Accurate and robust prediction of patient's response to drug treatments is critical for developing precision medicine. However, it is often difficult to obtain a sufficient amount of coherent drug response data from patients directly for…

Machine Learning · Computer Science 2021-02-02 Di He , Lei Xie

Many complex systems in the real world can be characterized by attributed networks. To mine the potential information in these networks, deep embedded clustering, which obtains node representations and clusters simultaneously, has been paid…

Machine Learning · Computer Science 2022-05-31 Yimei Zheng , Caiyan Jia , Jian Yu , Xuanya Li

Majority of research in learning based methods has been towards designing and training networks for specific tasks. However, many of the learning based tasks, across modalities, share commonalities and could be potentially tackled in a…

Computer Vision and Pattern Recognition · Computer Science 2023-11-13 Siddharth Srivastava , Gaurav Sharma

In biomedical research, to obtain more accurate prediction results from a target study, leveraging information from multiple similar source studies is proved to be useful. However, in many biomedical applications based on real-world data,…

Methodology · Statistics 2025-12-29 Xiaokang Liu , Jie Hu , Naimin Jing , Yang Ning , Cheng Yong Tang , Runze Li , Yong Chen

The solution of high-dimensional inference and prediction problems in computational biology is almost always a compromise between mathematical theory and practical constraints such as limited computational resources. As time progresses,…

Quantitative Methods · Quantitative Biology 2009-01-13 Anagha Joshi , Riet De Smet , Kathleen Marchal , Yves Van de Peer , Tom Michoel

Artificial neural networks have become important to improve the search for admissible string compactifications and characterize them. In this paper we construct the heterotic orbiencoder, a general deep autoencoder to study heterotic…

High Energy Physics - Theory · Physics 2024-01-31 Enrique Escalante-Notario , Ignacio Portillo-Castillo , Saul Ramos-Sanchez

We present an autoencoder that leverages learned representations to better measure similarities in data space. By combining a variational autoencoder with a generative adversarial network we can use learned feature representations in the…

Machine Learning · Computer Science 2016-02-12 Anders Boesen Lindbo Larsen , Søren Kaae Sønderby , Hugo Larochelle , Ole Winther

We propose a cell segmentation method for analyzing images of densely clustered cells. The method combines the strengths of marker-controlled watershed transformation and a convolutional neural network (CNN). We demonstrate the method…

Image and Video Processing · Electrical Eng. & Systems 2020-04-06 Filip Lux , Petr Matula

Cell segmentation is a critical step for quantitative single-cell analysis in microscopy images. Existing cell segmentation methods are often tailored to specific modalities or require manual interventions to specify hyper-parameters in…

This paper addresses the challenges of detecting anomalies in cellular networks in an interpretable way and proposes a new approach using variational autoencoders (VAEs) that learn interpretable representations of the latent space for each…

Machine Learning · Computer Science 2023-06-29 Amandeep Singh , Michael Weber , Markus Lange-Hegermann

An approach that combines Self-Organizing maps, hierarchical clustering and network components is presented, aimed at comparing protein conformational ensembles obtained from multiple Molecular Dynamic simulations. As a first result the…

Computational Engineering, Finance, and Science · Computer Science 2013-10-01 Domenico Fraccalvieri , Laura Bonati , Fabio Stella

Several recent results in machine learning have established formal connections between autoencoders---artificial neural network models that attempt to reproduce their inputs---and other coding models like sparse coding and K-means. This…

Machine Learning · Computer Science 2013-01-22 Leif Johnson , Craig Corcoran

We introduce a new neural architecture and an unsupervised algorithm for learning invariant representations from temporal sequence of images. The system uses two groups of complex cells whose outputs are combined multiplicatively: one that…

Neural and Evolutionary Computing · Computer Science 2010-06-03 Karo Gregor , Yann LeCun

The incorporation of prior knowledge into learning is essential in achieving good performance based on small noisy samples. Such knowledge is often incorporated through the availability of related data arising from domains and tasks similar…

Machine Learning · Statistics 2026-02-24 Baruch Epstein , Ron Meir , Tomer Michaeli

The voxelized Allen Atlas of the adult mouse brain (at a resolution of 200 microns) has been used in [arXiv:1303.0013] to estimate the region-specificity of 64 cell types whose transcriptional profile in the mouse brain has been measured in…

Neurons and Cognition · Quantitative Biology 2014-02-19 Pascal Grange , Jason W. Bohland , Benjamin Okaty , Ken Sugino , Hemant Bokil , Sacha Nelson , Lydia Ng , Michael Hawrylycz , Partha P. Mitra

Multi-modal learning focuses on training models by equally combining multiple input data modalities during the prediction process. However, this equal combination can be detrimental to the prediction accuracy because different modalities…

Computer Vision and Pattern Recognition · Computer Science 2022-07-25 Hu Wang , Jianpeng Zhang , Yuanhong Chen , Congbo Ma , Jodie Avery , Louise Hull , Gustavo Carneiro