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Causal structure learning has been a challenging task in the past decades and several mainstream approaches such as constraint- and score-based methods have been studied with theoretical guarantees. Recently, a new approach has transformed…

Machine Learning · Computer Science 2019-11-19 Ignavier Ng , Shengyu Zhu , Zhitang Chen , Zhuangyan Fang

Multimodal learning has mainly focused on learning large models on, and fusing feature representations from, different modalities for better performances on downstream tasks. In this work, we take a detour from this trend and study the…

Computer Vision and Pattern Recognition · Computer Science 2023-05-08 Yifeng Shi , Marc Niethammer

Revealing the functional sites of biological sequences, such as evolutionary conserved, structurally interacting or co-evolving protein sites, is a fundamental, and yet challenging task. Different frameworks and models were developed to…

Quantitative Methods · Quantitative Biology 2019-06-07 Justas Dauparas , Haobo Wang , Avi Swartz , Peter Koo , Mor Nitzan , Sergey Ovchinnikov

We demonstrate in this paper that a generative model can be designed to perform classification tasks under challenging settings, including adversarial attacks and input distribution shifts. Specifically, we propose a conditional variational…

Computer Vision and Pattern Recognition · Computer Science 2019-02-12 Houpu Yao , Malcolm Regan , Yezhou Yang , Yi Ren

Learned image reconstruction techniques using deep neural networks have recently gained popularity, and have delivered promising empirical results. However, most approaches focus on one single recovery for each observation, and thus neglect…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Chen Zhang , Riccardo Barbano , Bangti Jin

Associative memories in the brain receive and store patterns of activity registered by the sensory neurons, and are able to retrieve them when necessary. Due to their importance in human intelligence, computational models of associative…

Machine Learning · Computer Science 2021-09-17 Tommaso Salvatori , Yuhang Song , Yujian Hong , Simon Frieder , Lei Sha , Zhenghua Xu , Rafal Bogacz , Thomas Lukasiewicz

Distributional text clustering delivers semantically informative representations and captures the relevance between each word and semantic clustering centroids. We extend the neural text clustering approach to text classification tasks by…

Computation and Language · Computer Science 2020-11-25 Yekun Chai , Haidong Zhang , Shuo Jin

Multimodal learning leverages complementary information derived from different modalities, thereby enhancing performance in medical image segmentation. However, prevailing multimodal learning methods heavily rely on extensive well-annotated…

Computer Vision and Pattern Recognition · Computer Science 2024-09-05 Xiaogen Zhou , Yiyou Sun , Min Deng , Winnie Chiu Wing Chu , Qi Dou

Convolutional neural networks excel in histopathological image classification, yet their pixel-level focus hampers explainability. Conversely, emerging graph convolutional networks spotlight cell-level features and medical implications.…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Ziqi Yang , Zhongyu Li , Chen Liu , Xiangde Luo , Xingguang Wang , Dou Xu , Chaoqun Li , Xiaoying Qin , Meng Yang , Long Jin

Multi-view representation learning has developed rapidly over the past decades and has been applied in many fields. However, most previous works assumed that each view is complete and aligned. This leads to an inevitable deterioration in…

Computer Vision and Pattern Recognition · Computer Science 2022-11-10 Yiming Wang , Dongxia Chang , Zhiqiang Fu , Jie Wen , Yao Zhao

Computer-aided diagnosis (CAD) systems play a crucial role in analyzing neuroimaging data for neurological and psychiatric disorders. However, small-sample studies suffer from low reproducibility, while large-scale datasets introduce…

Machine Learning · Computer Science 2025-08-12 Xinglin Zhao , Yanwen Wang , Xiaobo Liu , Yanrong Hao , Rui Cao , Xin Wen

Multimodal molecular representation learning, which jointly models molecular graphs and their textual descriptions, enhances predictive accuracy and interpretability by enabling more robust and reliable predictions of drug toxicity,…

Machine Learning · Computer Science 2025-10-21 Yingxu Wang , Kunyu Zhang , Jiaxin Huang , Nan Yin , Siwei Liu , Eran Segal

Deep Learning has been widely applied in the area of image processing and natural language processing. In this paper, we propose an end-to-end communication structure based on autoencoder where the transceiver can be optimized jointly. A…

Information Theory · Computer Science 2019-06-18 Tianjie Mu , Xiaohui Chen , Li Chen , Huarui Yin , Weidong Wang

Modern single-cell flow and mass cytometry technologies measure the expression of several proteins of the individual cells within a blood or tissue sample. Each profiled biological sample is thus represented by a set of hundreds of…

Machine Learning · Computer Science 2022-06-29 Siyuan Shan , Vishal Baskaran , Haidong Yi , Jolene Ranek , Natalie Stanley , Junier Oliva

Neural generative models can be used to learn complex probability distributions from data, to sample from them, and to produce probability density estimates. We propose a computational framework for developing neural generative models…

Machine Learning · Computer Science 2022-01-06 Alexander Ororbia , Daniel Kifer

Discovering genes with similar functions across diverse biomedical contexts poses a significant challenge in gene representation learning due to data heterogeneity. In this study, we resolve this problem by introducing a novel model called…

Machine Learning · Computer Science 2023-10-05 Tianyu Liu , Yuge Wang , Rex Ying , Hongyu Zhao

This work presents a novel method of exploring human brain-visual representations, with a view towards replicating these processes in machines. The core idea is to learn plausible computational and biological representations by correlating…

Computer Vision and Pattern Recognition · Computer Science 2020-04-21 Simone Palazzo , Concetto Spampinato , Isaak Kavasidis , Daniela Giordano , Joseph Schmidt , Mubarak Shah

We present a handcrafted neural network that, without training, solves the seemingly difficult problem of encoding an arbitrary set of integers into a single numerical variable, and then recovering the original elements. While using only…

Neural and Evolutionary Computing · Computer Science 2025-06-17 Assaf Marron

We introduce combinatorial interpretability, a methodology for understanding neural computation by analyzing the combinatorial structures in the sign-based categorization of a network's weights and biases. We demonstrate its power through…

Machine Learning · Computer Science 2025-05-07 Micah Adler , Dan Alistarh , Nir Shavit

This paper introduces an efficient and robust method for discovering interpretable circuits in large language models using discrete sparse autoencoders. Our approach addresses key limitations of existing techniques, namely computational…

Computation and Language · Computer Science 2024-05-22 Charles O'Neill , Thang Bui
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