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Historically, patient datasets have been used to develop and validate various reconstruction algorithms for PET/MRI and PET/CT. To enable such algorithm development, without the need for acquiring hundreds of patient exams, in this paper we…

We propose a 3D neural network with specific loss functions for quantitative computed tomography (QCT) noise reduction to compute micro-structural parameters such as tissue mineral density (TMD) and bone volume ratio (BV/TV) with…

Image and Video Processing · Electrical Eng. & Systems 2020-11-11 Felix Thomsen , José M. Fuertes García , Manuel Lucena , Juan Pisula , Rodrigo de Luis García , Jan Broggrefe , Claudio Delrieux

In positron emission tomography (PET), time-of-flight (TOF) information localizes source positions along lines of response. Cherenkov-radiator-integrated microchannel-plate photomultiplier tubes have achieved 30 ps TOF resolution,…

Ultra high field (UHF) brain MRI has proved its value by providing enhanced SNR, contrast, and higher resolution derived from the higher magnetic field (B0). Nonetheless, with the increased B0 of UHF MRI, the transmit RF magnetic field…

Medical Physics · Physics 2019-11-14 Yunchan Hwang , Hansol Noh , Minkyu Park , Jongho Lee , Namkyoo Park

Positron Emission Tomography (PET) image reconstruction is inherently challenged by Poisson noise and physical degradation factors, which are further exacerbated in limited-angle acquisitions. While deep learning methods demonstrate…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Rüveyda Yilmaz , Yuli Wu , Johannes Stegmaier , Volkmar Schulz

We conducted a multi-institutional audit of dosimetric variability between FLASH and conventional dose rate (CONV) electron irradiations by using an anatomically realistic 3D-printed mouse phantom. A CT scan of a live mouse was used to…

Although supervised convolutional neural networks (CNNs) often outperform conventional alternatives for denoising positron emission tomography (PET) images, they require many low- and high-quality reference PET image pairs. Herein, we…

Medical Physics · Physics 2021-09-29 Yuya Onishi , Fumio Hashimoto , Kibo Ote , Hiroyuki Ohba , Ryosuke Ota , Etsuji Yoshikawa , Yasuomi Ouchi

Tissue and water equivalence of some phantom materials originally developed for conventional radiation therapy was investigated on the ITEP medical proton beam facility. The proton CSDA range in three variants of Plastic Water, lung,…

Despite its tremendous value for the diagnosis, treatment monitoring and surveillance of children with cancer, whole body staging with positron emission tomography (PET) is time consuming and associated with considerable radiation exposure.…

With the increasing popularity of PET-MR scanners in clinical applications, synthesis of CT images from MR has been an important research topic. Accurate PET image reconstruction requires attenuation correction, which is based on the…

Computer Vision and Pattern Recognition · Computer Science 2018-07-31 Snehashis Roy , John A. Butman , Dzung L. Pham

OBJECTIVES: Quantitative MRI techniques such as T2 and T1$\rho$ mapping are beneficial in evaluating cartilage and meniscus. We aimed to evaluate the MIXTURE (Multi-Interleaved X-prepared Turbo-Spin Echo with IntUitive RElaxometry)…

Background: Treatment verification with PET imaging in charged particle therapy is conventionally done by comparing measurements of spatial distributions with Monte Carlo (MC) predictions. However, decay curves can provide additional…

Whole-body PET imaging is often hindered by respiratory motion during acquisition, causing significant degradation in the quality of reconstructed activity images. An additional challenge in PET/CT imaging arises from the respiratory phase…

Osteoclastic resorption of bone plays a central role in both osteoporosis and bone metastasis. A reliable in vitro assay that simulates osteoclastic resorption in vivo would significantly speed up the process of devel-oping effective…

Tissues and Organs · Quantitative Biology 2021-04-13 Sijia Chen , Qiong Wang , Felipe Eltit , Yubin Guo , Michael Cox , Rizhi Wang

We report on the synthesis, characterization, stability and pharmacokinetics of novel iron based contrast agents for magnetic resonance imaging (MRI). Statistical copolymers combining multiple phosphonic acid groups and poly(ethylene…

Biomolecules · Quantitative Biology 2021-09-21 G. Ramniceanu , B. -T. Doan , C. Vezignol , A. Graillot , C. Loubat , N. Mignet , J. -F. Berret

Partial Volume effects are present at the boundary between any two types of material in a CT image due to the scanner's Point Spread Function, finite voxel resolution, and importantly, the discrepancy in radiodensity between the two…

Image and Video Processing · Electrical Eng. & Systems 2023-09-06 Aren Beagley , Hannah Richards , Joshua W. Giles

The inclusion of small amounts of copper is often reported to enhance the mechanical and biointegrative performance of bioceramics towards tissue engineering applications. In this work, 3D scaffolds were additively manufactured by…

Medical Physics · Physics 2022-05-24 Shumin Pang , Dongwei Wu , Franz Kamutzki , Jens Kurreck , Aleksander Gurlo , Dorian A. H. Hanaor

This paper presents a practical guide to prepare inorganic solutions that mimic the photoacoustic properties of whole blood at specific levels of oxygenation in the range of 700 nm to 850 nm, both in terms of optical absorption properties…

Medical Physics · Physics 2025-12-02 Léa Davenet , Arthur Billon , Jacques Battaglia , S Lori Bridal , Jérôme Gateau

Standard dual-energy computed tomography (CT) uses two different X-ray energies to obtain energy-dependent tissue attenuation information to allow quantitative material decomposition. The combined use of dual-energy CT and positron emission…

Medical Physics · Physics 2020-12-30 Guobao Wang

We report on an hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA…