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Diffuse optical tomography (DOT) has been investigated as an alternative imaging modality for breast cancer detection thanks to its excellent contrast to hemoglobin oxidization level. However, due to the complicated non-linear photon…
Enhancement of human vision to get an insight to information content is of vital importance. The traditional histogram equalization methods have been suffering from amplified contrast with the addition of artifacts and a surprising…
High throughput real-time instruments are needed to acquire large data sets for detection and classification of rare events. Enabled by the photonic time stretch digitizer, a new class of instruments with record throughputs have led to the…
In medicine, visualizing chromosomes is important for medical diagnostics, drug development, and biomedical research. Unfortunately, chromosomes often overlap and it is necessary to identify and distinguish between the overlapping…
Synchrotron-based X-ray computed tomography is widely used for investigating inner structures of specimens at high spatial resolutions. However, potential beam damage to samples often limits the X-ray exposure during tomography experiments.…
Deep learning (DL) models for disease classification or segmentation from medical images are increasingly trained using transfer learning (TL) from unrelated natural world images. However, shortcomings and utility of TL for specialized…
Cortical lesions (CLs) have emerged as valuable biomarkers in multiple sclerosis (MS), offering high diagnostic specificity and prognostic relevance. However, their routine clinical integration remains limited due to subtle magnetic…
Optical micro-spectroscopy is an invaluable tool for studying and characterizing samples ranging from classical semiconductors to low-dimensional materials and heterostructures. To date, most implementations are based on point-scanning…
Content-based medical image retrieval is an important diagnostic tool that improves the explainability of computer-aided diagnosis systems and provides decision making support to healthcare professionals. Medical imaging data, such as…
Holography is an optical technique enabling to record phase objects. Holographic interferometry uses this faculty to make a phase object interfere with a memory of itself at a preceding time, recorded on a hologram. Interference fringes…
We are developing multi-chroic antenna-coupled TES detectors for CMB polarimetry. Multi-chroic detectors increase the mapping speed per focal plane area and provide greater discrimination of polarized galactic foregrounds with no increase…
Laser scanning microscopy enables the acquisition of 3D data in biomedical research. A fundamental challenge in visualizing 3D data is that common flat-panel displays, being 2D in nature, cannot faithfully reproduce light fields. Recent…
Hyperspectral imaging (HSI) is an advanced medical imaging modality that captures optical data across a broad spectral range, providing novel insights into the biochemical composition of tissues. HSI may enable precise differentiation…
In this paper, we review spatial light interference microscopy (SLIM), a common-path, phase-shifting interferometer, built onto a phase-contrast microscope, with white-light illumination. As one of the most sensitive quantitative phase…
An interferometric fluorescent microscope and a novel theoretic image reconstruction approach were developed and used to obtain super-resolution images of live biological samples and to enable dynamic real time tracking. The tracking…
In this paper we apply digital in-line holography to image opaque objects through a thick plano-concave pipe. Opaque fibers and opaque particles are considered}. Analytical expression of the intensity distribution in the CCD sensor plane is…
We suggest a new multimodal imaging technique for quantitatively measuring the integral (thickness-average) refractive index of the nuclei of live biological cells in suspension. For this aim, we combined quantitative phase microscopy with…
Current in vivo microscopy allows us detailed spatiotemporal imaging (3D+t) of complete organisms and offers insights into their development on the cellular level. Even though the imaging speed and quality is steadily improving,…
In this paper the bright-field defocusing microscopy (DM) technique is presented. DM is able to obtain quantitative information of each plane/surface of pure phase objects, as live unlabeled cells, and its application to red blood cells…
Digital holographic microcopy is a thriving imaging modality that attracts considerable research interest due to its ability to not only create excellent label-free contrast, but also supply valuable physical information regarding the…