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Dendritic keratitis is a form of eye infection caused by herpes simplex virus (HSV). The virus spreads via direct cell-to-cell infection among corneal epithelial cells. This leads to the formation of dendritic lesions characterized by…
When the body gets infected by a pathogen or receives a vaccine dose, the immune system develops pathogen-specific immunity. Induced immunity decays in time and years after recovery/vaccination the host might become susceptible again.…
Macrophages in atherosclerotic lesions exhibit a spectrum of behaviours or phenotypes. The phenotypic distribution of monocyte-derived macrophages (MDMs), its correlation with MDM lipid content, and relation to blood lipoprotein densities…
Developing epithelial tissues coordinate cell proliferation and mechanical forces to achieve proper size and shape. As epithelial cells tightly adhere together to form the confluent tissue, the distribution of cell areas significantly…
It is now increasingly realized that the underlying mechanism which governs aging (ageing) is a complex interplay of genetic regulation and damage-accumulation. "Aging as a result of accumulation of 'faults' on cellular and molecular…
Understanding the spread of diseases through complex networks is of great interest where realistic, heterogeneous contact patterns play a crucial role in the spread. Most works have focused on mean-field behavior -- quantifying how contact…
To better describe the spread of a disease, we extend a discrete time stochastic SIR-type epidemic model of Tuckwell and Williams. We assume the dependence on time of the number of daily encounters and include a parameter to represent a…
Fibrous dysplasia (FD) is a mosaic non-inheritable genetic disorder of the skeleton in which normal bone is replaced by structurally unsound fibro-osseous tissue. There is no curative treatment for FD, partly because its pathophysiology is…
In this paper we study a mathematical model for an infectious disease such as Cholera without life-time immunity. Due to the different mobility for susceptible, infected human and recovered human hosts, the diffusion coefficients are…
In this study, we provide a dynamical systems perspective to the modelling of pathological states induced by tumors or infection. A unified disease model is established using the innate immune system as the reference point. We propose a…
During embryonic development tissue morphogenesis and signaling are tightly coupled. It is therefore important to simulate both tissue morphogenesis and signaling simultaneously in in silico models of developmental processes. The resolution…
The histological assessment of human tissue has emerged as the key challenge for detection and treatment of cancer. A plethora of different data sources ranging from tissue microarray data to gene expression, proteomics or metabolomics data…
Millions of melanocytic skin lesions are examined by pathologists each year, the majority of which concern common nevi (i.e., ordinary moles). While most of these lesions can be diagnosed in seconds, writing the corresponding pathology…
We develop a model for speciation due to postzygotic incompatibility generated by autoimmune reactions. The model is based on predator-prey interactions between a host plants and their pathogens. Such interactions are often…
Lipolysis is a life-essential metabolic process, which supplies fatty acids stored in lipid droplets to the body in order to match the demands of building new cells and providing cellular energy. In this paper, we present a first…
We found the analytical solution to the problem of the skin effect for Maxwell plasma with the use of the kinetic equation, where the frequency of electron collisions is constant. We use the specular reflection of electrons from the surface…
Advances in healthcare and in the quality of life significantly increase human life expectancy. With the ageing of populations, new un-faced challenges are brought to science. The human body is naturally selected to be well-functioning…
Therapeutic strategies to correct an excessive immune response to pathogenic infection is investigated as an optimal control problem. The control problem is formulated around a four dimensional mathematical model describing the inflammatory…
Malignant melanoma has one of the most rapidly increasing incidences in the world and has a considerable mortality rate. Early diagnosis is particularly important since melanoma can be cured with prompt excision. Dermoscopy images play an…
There are a lot of hidden dangers in the change of human skin conditions, such as the sunburn caused by long-time exposure to ultraviolet radiation, which not only has aesthetic impact causing psychological depression and lack of…