Related papers: Immunopathogenesis in Psoriasis through a Density-…
During growth, tissue expands and deforms. Given its elastic properties, stresses emerge in an expanding and deforming tissue. Cell rearrangements can dissipate these stresses and numerous experiments confirm the viscoelastic properties of…
We consider machine-learning-based malignancy prediction and lesion identification from clinical dermatological images, which can be indistinctly acquired via smartphone or dermoscopy capture. Additionally, we do not assume that images…
In this work we propose a new biophysical computational model of brain regions relevant to Parkinson's Disease based on local field potential data collected from the brain of marmoset monkeys. Parkinson's disease is a neurodegenerative…
Recent experiments in epithelial wound healing have demonstrated the necessity of Mitogen-activated protein kinase (MAPK) for coordinated cell movement after damage. This MAPK activity is characterized by two wave-like phenomena. One MAPK…
Skin diseases, such as skin cancer, are a significant public health issue, and early diagnosis is crucial for effective treatment. Artificial intelligence (AI) algorithms have the potential to assist in triaging benign vs malignant skin…
Melanoma is one of the most aggressive forms of skin cancer, causing a large proportion of skin cancer deaths. However, melanoma diagnoses by pathologists shows low interrater reliability. As melanoma is a cancer of the melanocyte, there is…
Two factors that are often ignored but could play a crucial role in the progression of an infectious disease are the distributions of inherent susceptibility ($\sigma_{inh}$) and external infectivity ($\iota_{ext}$), in a given population.…
Tip growth in filamentous cells, such as root hairs, moss protonemata, and fungal hyphae, depends on coordinated cell wall extension driven by turgor pressure, wall mechanics, and exocytosis. We introduce a dual-configuration model that…
Sarcoidosis is a rare inflammatory disease characterized by the formation of granulomas in various organs. The disease presents diagnostic and treatment challenges due to its diverse manifestations and unpredictable nature. In this study,…
Parkinson's disease (PD) is a common neurodegenerative disorder with a poorly understood physiopathology and no established biomarkers for the diagnosis of early stages and for prediction of disease progression. Several neuroimaging…
The main purpose of this paper is to study the existence of periodic solutions for a nonautonomous differential-difference system describing the dynamics of hematopoietic stem cell (HSC) population under some external periodic regulatory…
The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immunodegradation that indicate signs of functionality loss possibly leading to death. Even though it…
Immunotherapy has recently shown important clinical successes in a substantial number of oncology indications. Additionally, the tumor somatic mutation load has been shown to associate with response to these therapeutic agents, and specific…
Hemostasis and thrombosis are often thought as two sides of the same clotting mechanism whereas hemostasis is a natural protective mechanism to prevent bleeding and thrombosis is a blood clot abnormally formulated inside a blood vessel,…
We explore the emergence of persistent infection in a patch of population, where the disease progression of the individuals is given by the SIRS model and an individual becomes infected on contact with another infected individual. We…
Models for resident infectious diseases, like the SIRS model, may settle into an endemic state with constant numbers of susceptible ($S$), infected ($I$) and recovered ($R$) individuals, where recovered individuals attain a temporary…
A key problem in modelling the evolution dynamics of infectious diseases is the mathematical representation of the mechanism of transmission of the contagion. Models with a finite number of subpopulations can be described via systems of…
Image-based personalized medicine has the potential to transform healthcare, particularly for diseases that exhibit heterogeneous progression such as Multiple Sclerosis (MS). In this work, we introduce the first treatment-aware…
Neuroinflammation immediately follows the onset of ischemic stroke. During this process, microglial cells are activated in and recruited to the tissue surrounding the irreversibly injured infarct core, referred to as the penumbra.…
The incubation period of a disease is the time between an initiating pathologic event and the onset of symptoms. For typhoid fever, polio, measles, leukemia and many other diseases, the incubation period is highly variable. Some affected…