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Retinitis pigmentosa (RP), one of the leading causes of vision loss and blindness globally, is a progressive retinal disease involving the degradation of photoreceptors (7) and/or retinal pigment epithelial cells (14). Affecting…
Atherosclerosis is a chronic inflammatory disease of the artery wall. The early stages of atherosclerosis are driven by interactions between lipids and monocyte-derived-macrophages (MDMs). The mechanisms that govern the spatial distribution…
Immunological self/not-self discrimination is conventionally seen as an extracellular event, involving interactions been receptors on T cells pre-educated to discriminate, and peptides bound to major histocompatibility complex proteins…
Among various possible causes of autoimmune disease, an important role is played by infections that can result in a breakdown of immune tolerance, primarily through the mechanism of "molecular mimicry". In this paper we propose and analyse…
Retinitis pigmentosa (RP) is a group of inherited degenerative eye diseases characterized by mutations in the genetic structure of the photoreceptors that leads to the premature death of both rod and cone photoreceptors. Defects in…
Multiple Sclerosis (MS) is a severe neurological disease characterized by inflammatory lesions in the central nervous system. Hence, predicting inflammatory disease activity is crucial for disease assessment and treatment. However, MS…
This paper proposes a proof of concept application of a biphasic constitutive model to identify the mechanical properties of in vivo human skin under extension. Although poromechanics theory has been extensively used to model other soft…
Dermatological conditions affect 1.9 billion people globally, yet accurate diagnosis remains challenging due to limited specialist availability and complex clinical presentations. Family history significantly influences skin disease…
Mechanisms of immunity, and of the host-pathogen interactions in general are among the most fundamental problems of medicine, ecology, and evolution studies. Here, we present a microscopic, protein-level, sequence-based model of immune…
Objective: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by unpredictable flares. This study aimed to develop a novel proteomics-based risk prediction model specifically for Asian SLE populations to…
In the studies of plant infections, the plant immune response is known to play an essential role. In this paper we derive and analyse a new mathematical model of plant immune response with particular account for post-transcriptional gene…
Skin diseases are among the most prevalent health issues, and accurate computer-aided diagnosis methods are of importance for both dermatologists and patients. However, most of the existing methods overlook the essential domain knowledge…
Malaria is one of the deadliest infectious diseases globally, causing hundreds of thousands of deaths each year. It disproportionately affects young children, with two-thirds of fatalities occurring in under-fives. Individuals acquire…
Sexually transmitted diseases (STDs) are a group of pathogens infecting new hosts through sexual interactions. Due to its social and economic burden, multiple models have been proposed to study the spreading of pathogens. In parallel, in…
In this work we adopt a statistical mechanics approach to investigate basic, systemic features exhibited by adaptive immune systems. The lymphocyte network made by B-cells and T-cells is modeled by a bipartite spin-glass, where, following…
For many complex diseases, there is a wide variety of ways in which an individual can manifest the disease. The challenge of personalized medicine is to develop tools that can accurately predict the trajectory of an individual's disease,…
This paper deals with the long-term behaviour and incidence of a vaccine-preventable contact disease, under the assumption that both vaccine protection and immunity after recovery are not lifelong. The mathematical model is developed in a…
Crohn's disease is an inflammatory bowel disease (IBD) that is not well understood. In particular, unlike other IBDs, the inflamed parts of the intestine compromise deep layers of the tissue and are not continuous but separated and…
Keratoconus is a pathology of the cornea associated with a tissue thinning and a weakening of its mechanical properties. However, it remains elusive which aspect is the leading cause of the disease. To investigate this question, we combined…
In this paper we propose a new approach to identify melanoma diseases by identifying the distribution of its main skin chromophores (melanin, oxyhemoglobin and deoxyhemoglobin) from multispectral dermatological images. Based on Blind Source…