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Fiber-based micro-endoscopes are a critically important tool for minimally-invasive deep-tissue imaging. However, the state-of-the-art micro-endoscopes cannot perform three-dimensional imaging through dynamically-bent fibers without the use…

Optics · Physics 2022-11-09 Noam Badt , Ori Katz

Lens-free on-chip digital holographic microscopy (LFOCDHM) is a modern imaging technique whereby the sample is placed directly onto or very close to the digital sensor, and illuminated by a partially coherent source located far above it.…

Optics · Physics 2019-06-17 Jialin Zhang , Jiasong Sun , Qian Chen , Chao Zuo

This study developed handheld and low-cost digital holographic microscopy (DHM) by adopting an in-line type hologram, a webcam, a high power RGB light emitting diode (LED), and a pinhole. It cost less than 20,000 yen (approximately 250 US…

Microscopes are vital pieces of equipment in much of biological research and medical diagnostics. However, access to a microscope can represent a bottleneck in research, especially in lower-income countries. `Smart' computer controlled…

Instrumentation and Detectors · Physics 2022-07-08 Samuel McDermott , Filip Ayazi , Joel Collins , Joe Knapper , Julian Stirling , Richard Bowman , Pietro Cicuta

Digital holography (DH) enables non-contact, noninvasive 3D imaging of transparent and moving microscopic samples by capturing amplitude and phase information in a single shot. In this work, we present a compact, low-cost, real-time…

Optics · Physics 2025-03-18 Yuki Nagahama

Digital holography has applications in bio-imaging because it can simultaneously obtain the amplitude and phase information of a microscopic sample in a single shot, thus facilitating non-contact, noninvasive observation of the 3D shape of…

Graphics · Computer Science 2024-06-14 Yuki Nagahama

Three-dimensional (3D) printing has emerged as a powerful tool for material, food, and life science research and development, where the technology democratization necessitates the advancement of open-source platforms. Herein, we developed a…

Soft Condensed Matter · Physics 2022-03-16 Iek Man Lei , Yaqi Sheng , Chon Lok Lei , Cillian Leow , Yan Yan Shery Huang

Open source hardware has the potential to revolutionise the way we build scientific instruments; with the advent of readily-available 3D printers, mechanical designs can now be shared, improved and replicated faster and more easily than…

Instrumentation and Detectors · Physics 2016-07-25 James P. Sharkey , Darryl C. W. Foo , Alexandre Kabla , Jeremy J. Baumberg , Richard W. Bowman

Ultrathin lensless fibre endoscopes offer minimally invasive investigation, but they mostly operate as a rigid type due to the need for prior calibration of a fibre probe. Furthermore, most implementations work in fluorescence mode rather…

Optics · Physics 2020-10-23 Wonjun Choi , Munkyu Kang , Jin Hee Hong , Ori Katz , Youngwoon Choi , Wonshik Choi

We propose to use high numerical aperture single mode optical fibers like photonic crystal fiber for lensless in-line holographic microscopy. Highly divergent beam helps to overcome the spatial sampling limitation of the image sensor. In…

Optics · Physics 2020-07-01 Sanjeev Kumar , Manjunatha Mahadevappa , Pranab K. Dutta

Microscopic analysis of micro particles in situ in diverse water environments is necessary for monitoring water quality and localizing contamination sources. Conventional sensors such as optical microscopes and fluorometers often require…

Robotics · Computer Science 2019-11-26 Kevin Mallery , Dario Canelon , Jiarong Hong , Nikolaos Papanikolopoulos

Exposure to laser light alters cell culture examination via optical microscopic imaging techniques, also based on label-free coherent digital holography. To mitigate this detrimental feature, researchers tend to use a broader spectrum and…

Multimodal nonlinear endoscopes have been a topic of intense research over the past two decades, enabling sub-cellular and label-free imaging in areas not reachable with table-top microscopes. They are sophisticated systems that can be…

The outbreak of COVID-19 exposed the inadequacy of our technical tools for home health surveillance, and recent studies have shown the potential of smartphones as a universal optical microscopic imaging platform for such applications.…

Image and Video Processing · Electrical Eng. & Systems 2023-12-20 Haoran Zhang , Weiyi Zhang , Zirui Zuo , Jianlong Yang

High-resolution lithographic techniques are often limited by low volumetric throughput, since there is no universal and scalable manufacturing process that can produce 3D metasurfaces. In this work, we demonstrate a high-speed holographic…

We demonstrate a simple and cost-efficient scanning confocal microscope setup for use in advanced instructional physics laboratories. The setup is constructed from readily available commercial products, and the implementation of a…

Physics Education · Physics 2023-05-03 A. Reguilon , W. Bethard , E. Brekke

Photolithography is a key part of modern semiconductor process flows, and photolithography steppers have been used for decades to achieve precise patterning for device fabrication. However, these tools are often large and expensive, which…

Instrumentation and Detectors · Physics 2025-10-20 B. Joel Gonzalez , Elio Bourcart , J. Kent Wirant , Michael Juan , Justin Wang , Matthew T. Moneck

Digital holographic microscopy is a powerful tool for characterizing transparent and reflective phase objects. Its ability to reconstruct amplitude and phase can also offer great insight into wavefront shaping and design of all-dielectric…

Lensless microscopy with coherent or partially coherent light sources is a well known imaging technique, commonly referred as digital in-line holographic microscopy. In the established methods, both the spatial and temporal coherence of…

Optics · Physics 2020-11-04 Sanjeev Kumar , Manjunatha Mahadevappa , Pranab Kumar Dutta

We present a 3D-printing-based design to produce wire-guided liquid microfilms that can be used for versatile spectroscopic applications. We demonstrate the ability of our instrument to provide optically useful liquid microfilms with highly…

Chemical Physics · Physics 2025-07-04 Matthew J. Silverstein , Yasashri Ranathunga , Yuki Kobayashi
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