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Related papers: Achieving GWAS with Homomorphic Encryption

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Homomorphic Encryption (HE) enables computation on encrypted data without decryption, making it a cornerstone of privacy-preserving computation in untrusted environments. As HE sees growing adoption in sensitive applications such as secure…

Cryptography and Security · Computer Science 2025-09-30 Matias Mazzanti , Augusto Vega , Pradip Bose , Esteban Mocskos

The aetiology of polygenic obesity is multifactorial, which indicates that life-style and environmental factors may influence multiples genes to aggravate this disorder. Several low-risk single nucleotide polymorphisms (SNPs) have been…

Genomics · Quantitative Biology 2018-08-27 Casimiro A. Curbelo Montañez , Paul Fergus , Carl Chalmers , Jade Hind

We present an alternative method for genome-wide association studies (GWAS) that is more powerful than the regular GWAS method for locus detection. The regular GWAS method suffers from a substantial multiple-testing burden because of the…

Applications · Statistics 2018-12-19 William Denault , Håkon K. Gjessing , Julius Juodakis , Bo Jacobsson , Astanand Jugessur

Modern face recognition systems utilize deep neural networks to extract salient features from a face. These features denote embeddings in latent space and are often stored as templates in a face recognition system. These embeddings are…

Cryptography and Security · Computer Science 2024-04-26 Bharat Yalavarthi , Arjun Ramesh Kaushik , Arun Ross , Vishnu Boddeti , Nalini Ratha

We present automatically parameterised Fully Homomorphic Encryption (FHE) for encrypted neural network inference and exemplify our inference over FHE compatible neural networks with our own open-source framework and reproducible examples.…

Machine Learning · Computer Science 2022-10-19 George Onoufriou , Marc Hanheide , Georgios Leontidis

Sparse matrix-vector multiplication (SpMV) is a fundamental operation in scientific computing, data analysis, and machine learning. When the data being processed are sensitive, preserving privacy becomes critical, and homomorphic encryption…

Cryptography and Security · Computer Science 2026-03-06 Yang Gao , Gang Quan , Wujie Wen , Scott Piersall , Qian Lou , Liqiang Wang

Homomorphic encryption is a sophisticated encryption technique that allows computations on encrypted data to be done without the requirement for decryption. This trait makes homomorphic encryption appropriate for safe computation in…

Cryptography and Security · Computer Science 2023-05-11 Nimish Jain , Aswani Kumar Cherukuri

Outsourced computation for neural networks allows users access to state of the art models without needing to invest in specialized hardware and know-how. The problem is that the users lose control over potentially privacy sensitive data.…

Cryptography and Security · Computer Science 2022-01-04 Robert Podschwadt , Daniel Takabi , Peizhao Hu

Data privacy is a significant concern when using numerical simulations for sensitive information such as medical, financial, or engineering data -- especially in untrusted environments like public cloud infrastructures. Fully homomorphic…

Numerical Analysis · Mathematics 2025-09-25 Arseniy Kholod , Yuriy Polyakov , Michael Schlottke-Lakemper

Homomorphic encryption (HE) is a promising cryptographic technique for enabling secure collaborative machine learning in the cloud. However, support for homomorphic computation on ciphertexts under multiple keys is inefficient. Current…

Cryptography and Security · Computer Science 2019-11-12 Asma Aloufi , Peizhao Hu

Homomorphic encryption (HE) is a privacy-preserving technique that enables computation directly over ciphertext. Unfortunately, a key challenge for HE is that implementations can be impractically slow and have limits on computation that can…

Cryptography and Security · Computer Science 2022-03-08 Hsuan Hsiao , Vincent Lee , Brandon Reagen , Armin Alaghi

Homomorphic encryption (HE) has found extensive utilization in federated learning (FL) systems, capitalizing on its dual advantages: (i) ensuring the confidentiality of shared models contributed by participating entities, and (ii) enabling…

Cryptography and Security · Computer Science 2023-08-10 Dongfang Zhao

Encrypted control has been introduced to protect controller data by encryption at the stage of computation and communication, by performing the computation directly on encrypted data. In this article, we first review and categorize recent…

Cryptography and Security · Computer Science 2022-10-12 Junsoo Kim , Dongwoo Kim , Yongsoo Song , Hyungbo Shim , Henrik Sandberg , Karl H. Johansson

In this paper we compare the performance of various homomorphic encryption methods on a private search scheme that can achieve $k$-anonymity privacy. To make our benchmarking fair, we use open sourced cryptographic libraries which are…

Cryptography and Security · Computer Science 2017-03-27 Shiyu Ji , Kun Wan

The use of Machine Learning (ML) for data-driven decision-making often relies on access to sensitive datasets, which introduces privacy challenges. Traditional encryption methods protect data at rest or in transit but fail to secure it…

Cryptography and Security · Computer Science 2026-04-28 Alexandre Marques , Beatriz Sá , Rui Botelho , Pedro Pinto

Machine learning on encrypted data can address the concerns related to privacy and legality of sharing sensitive data with untrustworthy service providers. Fully Homomorphic Encryption (FHE) is a promising technique to enable machine…

Cryptography and Security · Computer Science 2021-02-02 Nayna Jain , Karthik Nandakumar , Nalini Ratha , Sharath Pankanti , Uttam Kumar

We present a method to search for a probe (or query) image representation against a large gallery in the encrypted domain. We require that the probe and gallery images be represented in terms of a fixed-length representation, which is…

Computer Vision and Pattern Recognition · Computer Science 2022-06-22 Joshua J. Engelsma , Anil K. Jain , Vishnu Naresh Boddeti

Privacy concerns have thrust privacy-preserving computation into the spotlight. Homomorphic encryption (HE) is a cryptographic system that enables computation to occur directly on encrypted data, providing users with strong privacy (and…

Cryptography and Security · Computer Science 2024-05-21 Juran Ding , Yuanzhe Liu , Lingbin Sun , Brandon Reagen

Standard approaches to analysing data in genome-wide association studies (GWAS) ignore any potential functional relationships between genetic markers. In contrast gene pathways analysis uses prior information on functional structure within…

Methodology · Statistics 2013-02-26 M. Silver , P. Chen , L. Ruoying , C. Y. Cheng , T. Y. Wong , E. Tai , Y. Y. Teo , G. Montana

Traditional approaches to vector similarity search over encrypted data rely on fully homomorphic encryption (FHE) to enable computation without decryption. However, the substantial computational overhead of FHE makes it impractical for…

Cryptography and Security · Computer Science 2025-02-21 Dongfang Zhao