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Although numerous complex algorithms for treatment effect estimation have been developed in recent years, their effectiveness remains limited when handling insufficiently labeled training sets due to the high cost of labeling the effect…

Machine Learning · Computer Science 2025-05-09 Hechuan Wen , Tong Chen , Mingming Gong , Li Kheng Chai , Shazia Sadiq , Hongzhi Yin

Inferring causal effects of continuous-valued treatments from observational data is a crucial task promising to better inform policy- and decision-makers. A critical assumption needed to identify these effects is that all confounding…

Treatment effect estimation is essential for informed decision-making in many fields such as healthcare, economics, and public policy. While flexible machine learning models have been widely applied for estimating heterogeneous treatment…

Machine Learning · Computer Science 2025-09-29 Pascal Memmesheimer , Vincent Heuveline , Jürgen Hesser

Biphasic, non-sigmoidal dose-response relationships are frequently observed in biochemistry and pharmacology, but they are not always analyzed with appropriate statistical methods. Here, we examine curve fitting methods for "hormetic"…

Quantitative Methods · Quantitative Biology 2023-08-21 Venkat D. Abbaraju , Tamaraty L. Robinson , Brian P. Weiser

Informed selection of drug candidates for laboratory experimentation provides an efficient means of identifying suitable anti-cancer treatments. The advancement of artificial intelligence has led to the development of computational models…

Counterfactual explanations are one of the most popular methods to make predictions of black box machine learning models interpretable by providing explanations in the form of `what-if scenarios'. Most current approaches optimize a…

Machine Learning · Statistics 2020-10-16 Susanne Dandl , Christoph Molnar , Martin Binder , Bernd Bischl

Open-domain dialogue generation suffers from the data insufficiency problem due to the vast size of potential responses. In this paper, we propose to explore potential responses by counterfactual reasoning. Given an observed response, the…

Machine Learning · Computer Science 2020-10-12 Qingfu Zhu , Weinan Zhang , Ting Liu , William Yang Wang

Predictions under interventions are estimates of what a person's risk of an outcome would be if they were to follow a particular treatment strategy, given their individual characteristics. Such predictions can give important input to…

Methodology · Statistics 2025-06-17 Ruth H. Keogh , Nan van Geloven

In this paper, we address the challenge of performing counterfactual inference with observational data via Bayesian nonparametric regression adjustment, with a focus on high-dimensional settings featuring multiple actions and multiple…

Machine Learning · Computer Science 2022-11-22 Alberto Caron , Gianluca Baio , Ioanna Manolopoulou

Controlled interventions provide the most direct source of information for learning causal effects. In particular, a dose-response curve can be learned by varying the treatment level and observing the corresponding outcomes. However,…

Machine Learning · Statistics 2016-05-06 Ricardo Silva

Learning curves are a measure for how the performance of machine learning models improves given a certain volume of training data. Over a wide variety of applications and models it was observed that learning curves follow -- to a large…

Machine Learning · Computer Science 2023-10-13 Laura Didyk , Brayden Yarish , Michael A. Beck , Christopher P. Bidinosti , Christopher J. Henry

Individualized treatment regimes (ITRs) aim to improve clinical outcomes by assigning treatment based on patient-specific characteristics. However, existing methods often struggle with high-dimensional covariates, limiting accuracy,…

Machine Learning · Statistics 2026-01-13 Sungtaek Son , Eardi Lila , Kwun Chuen Gary Chan

Estimation of temporal counterfactual outcomes from observed history is crucial for decision-making in many domains such as healthcare and e-commerce, particularly when randomized controlled trials (RCTs) suffer from high cost or…

Machine Learning · Computer Science 2024-02-13 Chuizheng Meng , Yihe Dong , Sercan Ö. Arık , Yan Liu , Tomas Pfister

Counterfactual explanations provide individuals with cost-optimal recommendations to achieve their desired outcomes. However, when a significant number of individuals seek similar state modifications, this individual-centric approach can…

Machine Learning · Computer Science 2025-10-01 Ahmad-Reza Ehyaei , Ali Shirali , Samira Samadi

Molecular property prediction is a crucial task that guides the design of new compounds, including drugs and materials. While explainable artificial intelligence methods aim to scrutinize model predictions by identifying influential…

Machine Learning · Computer Science 2025-08-27 Łukasz Janisiów , Marek Kochańczyk , Bartosz Zieliński , Tomasz Danel

The counterfactual distribution models the effect of the treatment in the untreated group. While most of the work focuses on the expected values of the treatment effect, one may be interested in the whole counterfactual distribution or…

Machine Learning · Statistics 2022-11-04 Diego Martinez-Taboada , Dino Sejdinovic

Counterfactual thinking describes a psychological phenomenon that people re-infer the possible results with different solutions about things that have already happened. It helps people to gain more experience from mistakes and thus to…

Machine Learning · Computer Science 2019-08-19 Yue Wang , Yao Wan , Chenwei Zhang , Lixin Cui , Lu Bai , Philip S. Yu

Learning to Rank (LTR) from user interactions is challenging as user feedback often contains high levels of bias and noise. At the moment, two methodologies for dealing with bias prevail in the field of LTR: counterfactual methods that…

Information Retrieval · Computer Science 2019-07-16 Rolf Jagerman , Harrie Oosterhuis , Maarten de Rijke

Learning-based approaches, such as reinforcement and imitation learning are gaining popularity in decision-making for autonomous driving. However, learned policies often fail to generalize and cannot handle novel situations well. Asking and…

Machine Learning · Computer Science 2020-11-13 Patrick Hart , Alois Knoll

Although pre-trained language models show good performance on various natural language processing tasks, they often rely on non-causal features and patterns to determine the outcome. For natural language inference tasks, previous results…

Computation and Language · Computer Science 2024-10-29 Heerin Yang , Sseung-won Hwang , Jungmin So
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