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Objective: Many recent studies have suggested that brain deformation resulting from a head impact is linked to the corresponding clinical outcome, such as mild traumatic brain injury (mTBI). Even though several finite element (FE) head…

Traumatic brain injury (TBI) occurs when local mechanical load exceeds certain tolerance levels for brain tissue. Extensive research has been done previously for brain matter experiencing compression at quasistatic loading; however, limited…

Biological Physics · Physics 2013-02-20 Badar Rashid , Michel Destrade , Michael Gilchrist

The mechanical characterization of brain tissue at high loading velocities is vital for understanding and modeling Traumatic Brain Injury (TBI). The most severe form of TBI is diffuse axonal injury (DAI) which involves damage to individual…

Biological Physics · Physics 2013-02-19 Badar Rashid , Michel Destrade , Michael Gilchrist

Mild Traumatic Brain Injuries (mTBI) are caused by violent head motions or impacts. Most mTBI prevention strategies explicitly or implicitly rely on a "brain injury criterion". A brain injury criterion takes some descriptor of the head's…

Medical Physics · Physics 2022-01-19 Yang Wan , Alice Lux Fawzi , Haneesh Kesari

Traumatic brain injury (TBI) is intrinsically heterogeneous, and typical clinical outcome measures like the Glasgow Coma Scale complicate this diversity. The large variability in severity and patient outcomes render it difficult to link…

Prognoses of Traumatic Brain Injury (TBI) outcomes are neither easily nor accurately determined from clinical indicators. This is due in part to the heterogeneity of damage inflicted to the brain, ultimately resulting in diverse and complex…

Head motion induced by impacts has been deemed as one of the most important measures in brain injury prediction, given that the majority of brain injury metrics use head kinematics as input. Recently, researchers have focused on using fast…

Quantitative Methods · Quantitative Biology 2020-12-11 Patricio Arrue , Nima Toosizadeh , Hessam Babaee , Kaveh Laksari

The identification and segmentation of moderate-severe traumatic brain injury (TBI) lesions pose a significant challenge in neuroimaging. This difficulty arises from the extreme heterogeneity of these lesions, which vary in size, number,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Ghanshyam Dhamat , Vaanathi Sundaresan

Traumatic brain injury (TBI) presents a significant public health challenge, often resulting in mortality or lasting disability. Predicting outcomes such as mortality and Functional Status Scale (FSS) scores can enhance treatment strategies…

Machine Learning · Computer Science 2024-10-29 Lucas Steinmetz , Shivam Maheshwari , Garik Kazanjian , Abigail Loyson , Tyler Alexander , Venkat Margapuri , C. Nataraj

Brain strain and strain rate are effective in predicting traumatic brain injury (TBI) caused by head impacts. However, state-of-the-art finite element modeling (FEM) demands considerable computational time in the computation, limiting its…

Traumatic brain injury (TBI) is caused by a sudden trauma to the head that may result in hematomas and contusions and can lead to stroke or chronic disability. An accurate quantification of the lesion volumes and their locations is…

Computer Vision and Pattern Recognition · Computer Science 2018-07-31 Snehashis Roy , John A. Butman , Leighton Chan , Dzung L. Pham

The accurate prognosis for traumatic brain injury (TBI) patients is difficult yet essential to inform therapy, patient management, and long-term after-care. Patient characteristics such as age, motor and pupil responsiveness, hypoxia and…

Computer Vision and Pattern Recognition · Computer Science 2022-08-09 Margherita Rosnati , Eyal Soreq , Miguel Monteiro , Lucia Li , Neil S. N. Graham , Karl Zimmerman , Carlotta Rossi , Greta Carrara , Guido Bertolini , David J. Sharp , Ben Glocker

Mechanical characterization of brain tissue at high loading velocities is crucial for modeling Traumatic Brain Injury (TBI). During severe impact conditions, brain tissue experiences compression, tension and shear. Limited experimental data…

Soft Condensed Matter · Physics 2020-09-03 Badar Rashid , Michel Destrade , Michael D. Gilchrist

Computer Tomography (CT) is the gold standard technique for brain damage evaluation after acute Traumatic Brain Injury (TBI). It allows identification of most lesion types and determines the need of surgical or alternative therapeutic…

Computer Vision and Pattern Recognition · Computer Science 2021-04-01 Ezequiel de la Rosa , Diana M. Sima , Thijs Vande Vyvere , Jan S. Kirschke , Bjoern Menze

Purpose: Computational head models are essential tools for studying the risk of mild traumatic brain injury (mTBI) under different activities and across populations. However, different computational models incorporate varied levels of…

Tissues and Organs · Quantitative Biology 2025-11-07 Anu Tripathi , Alison Brooks , Traci Snedden , Peter Ferrazzano , Christian Franck , Rika Wright Carlsen

Traumatic Brain Injury (TBI) is a common cause of death and disability. However, existing tools for TBI diagnosis are either subjective or require extensive clinical setup and expertise. The increasing affordability and reduction in size of…

Signal Processing · Electrical Eng. & Systems 2021-02-01 Navjodh Singh Dhillon , Agustinus Sutandi , Manoj Vishwanath , Miranda M. Lim , Hung Cao , Dong Si

Strain and strain rate are effective traumatic brain injury predictors. Kinematics-based models estimating these metrics suffer from significant different distributions of both kinematics and the injury metrics across head impact types. To…

Quantitative Methods · Quantitative Biology 2022-12-07 Xianghao Zhan , Yuzhe Liu , Nicholas J. Cecchi , Olivier Gevaert , Michael M. Zeineh , Gerald A. Grant , David B. Camarillo

Rotational head motions have been shown to play a key role in traumatic brain injury. There is great interest in developing methods to rapidly predict brain tissue strains and strain rates resulting from rotational head motions to estimate…

Medical Physics · Physics 2023-08-09 Yang Wan , Wenqiang Fang , Rika Wright Carlsen , Haneesh Kesari

Brain tissue deformation resulting from head impacts is primarily caused by rotation and can lead to traumatic brain injury. To quantify brain injury risk based on measurements of kinematics on the head, finite element (FE) models and…

Traumatic brain injuries (TBI) are considered a silent epidemic. It affects many people, from automobiles to sports to service members. In this study, we employed a musculoskeletal head-neck model to understand the effect of impact…

Tissues and Organs · Quantitative Biology 2024-12-09 Rahid Zaman , Ashfaq Adnan
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