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Automated segmentation of medical imaging is of broad interest to clinicians and machine learning researchers alike. The goal of segmentation is to increase efficiency and simplicity of visualization and quantification of regions of…

Image and Video Processing · Electrical Eng. & Systems 2020-06-04 Shruti Jadon , Owen P. Leary , Ian Pan , Tyler J. Harder , David W. Wright , Lisa H. Merck , Derek L. Merck

Traumatic Brain Injury (TBI) results from an impact or concussion to the head with the injury being specifically characterized through pathological degradation at various biological length scales. Following injury, various mechanical…

Quantitative Methods · Quantitative Biology 2025-11-26 Debabrata Auddya , Shiva Rudraraju

Mild traumatic brain injury (mTBI) is a growing public health problem with an estimated incidence of one million people annually in US. Neurocognitive tests are used to both assess the patient condition and to monitor the patient progress.…

Computer Vision and Pattern Recognition · Computer Science 2018-02-16 Shervin Minaee , Siyun Wang , Yao Wang , Sohae Chung , Xiuyuan Wang , Els Fieremans , Steven Flanagan , Joseph Rath , Yvonne W. Lui

Mild Traumatic Brain Injury (mTBI) is a significant public health problem. The most troubling symptoms after mTBI are cognitive complaints. Studies show measurable differences between patients with mTBI and healthy controls with respect to…

Image and Video Processing · Electrical Eng. & Systems 2019-11-12 Tongda Xu , Xiyan Cai , Yao Wang , Xiuyuan Wang , Sohae Chung , Els Fieremans , Joseph Rath , Steven Flanagan , Yvonne W Lui

Brain network analysis for traumatic brain injury (TBI) patients is critical for its consciousness level assessment and prognosis evaluation, which requires the segmentation of certain consciousness-related brain regions. However, it is…

Image and Video Processing · Electrical Eng. & Systems 2022-08-15 Xiangyu Zhao , Di Zang , Sheng Wang , Zhenrong Shen , Kai Xuan , Zeyu Wei , Zhe Wang , Ruizhe Zheng , Xuehai Wu , Zheren Li , Qian Wang , Zengxin Qi , Lichi Zhang

Tensor-based morphometry (TBM) aims at showing local differences in brain volumes with respect to a common template. TBM images are smooth but they exhibit (especially in diseased groups) higher values in some brain regions called lateral…

Background: Ventilator-associated pneumonia (VAP) in traumatic brain injury (TBI) patients poses a significant mortality risk and imposes a considerable financial burden on patients and healthcare systems. Timely detection and…

Machine Learning · Computer Science 2024-08-05 Negin Ashrafi , Armin Abdollahi , Maryam Pishgar

Brain deformation caused by a head impact leads to traumatic brain injury (TBI). The maximum principal strain (MPS) was used to measure the extent of brain deformation and predict injury, and the recent evidence has indicated that…

Signal Processing · Electrical Eng. & Systems 2024-09-16 Xianghao Zhan , Zhou Zhou , Yuzhe Liu , Nicholas J. Cecchi , Marzieh Hajiahamemar , Michael M. Zeineh , Gerald A. Grant , David Camarillo

A major challenge in stroke research and stroke recovery predictions is the determination of a stroke lesion's extent and its impact on relevant brain systems. Manual segmentation of stroke lesions from 3D magnetic resonance (MR) imaging…

Image and Video Processing · Electrical Eng. & Systems 2023-06-21 Sovesh Mohapatra , Advait Gosai , Anant Shinde , Aleksei Rutkovskii , Sirisha Nouduri , Gottfried Schlaug

Recently, the potential of dynamic brain networks as a neuroimaging biomarkers for mental illnesses is being increasingly recognized. However, there are several unmet challenges in developing such biomarkers, including the need for methods…

Neurons and Cognition · Quantitative Biology 2019-10-10 Suprateek Kundu , Jin Ming , Jennifer Stevens

The accurate diagnosis and assessment of neurodegenerative disease and traumatic brain injuries (TBI) remain open challenges. Both cause cognitive and functional deficits due to focal axonal swellings (FAS), but it is difficult to deliver a…

Neurons and Cognition · Quantitative Biology 2016-12-15 Bethany Lusch , Jake Weholt , Pedro D. Maia , J. Nathan Kutz

The discovery that repetitive mild traumatic brain injury (mTBI) can result in chronic traumatic encephalopathy (CTE) in high risk contact sports has led to increased scrutiny of head protective gear. In this work, we asked if it was…

Quantitative Methods · Quantitative Biology 2019-10-18 Hossein Vahid Alizadeh , Michael G. Fanton , August G. Domel , Gerald Grant , David Benjamin Camarillo

We present an algorithm for determining the acceleration field of a rigid body using measurements from four tri-axial accelerometers. The acceleration field is an important quantity in bio-mechanics problems, especially in the study of mild…

Medical Physics · Physics 2019-11-22 Mohammad Masiur Rahaman , Wenqiang Fang , Alice Lux Fawzi , Yang Wan , Haneesh Kesari

Magnetoencephalography (MEG) scanner has been shown to be more accurate than other medical devices in detecting mild traumatic brain injury (mTBI). However, MEG scan data in certain spectrum ranges can be skewed, multimodal and…

Methodology · Statistics 2025-02-07 Jian Zhang , Gary Green

Disease in the brain is often associated with subtle, spatially diffuse, or complex tissue changes that may lie beneath the level of gross visual inspection, even on magnetic resonance imaging (MRI). Unfortunately, current computer-assisted…

Computer Vision and Pattern Recognition · Computer Science 2017-05-16 Shinjini Kundu , Soheil Kolouri , Kirk I Erickson , Arthur F Kramer , Edward McAuley , Gustavo K Rohde

Computational biomechanics models of the brain have become an important tool for investigating the brain responses to mechanical loads. The geometry, loading conditions, and constitutive properties of such brain models are well-studied and…

Computational Engineering, Finance, and Science · Computer Science 2025-12-10 Sajjad Arzemanzadeh , Benjamin Zwick , Karol Miller , Tim Rosenow , Stuart I. Hodgetts , Adam Wittek

When a patient is admitted to the intensive care unit (ICU) after a traumatic brain injury (TBI), an early prognosis is essential for baseline risk adjustment and shared decision making. TBI outcomes are commonly categorised by the Glasgow…

Existing methods to characterise the evolving condition of traumatic brain injury (TBI) patients in the intensive care unit (ICU) do not capture the context necessary for individualising treatment. Here, we integrate all heterogenous data…

The trajectory of an individual's recovery after traumatic brain injury (TBI) is heterogeneous, with complete recovery in some cases but persistent disability in others. We hypothesized that changes in structural brain network abnormalities…

Mild Traumatic Brain Injury (mTBI) is a common and challenging condition to diagnose accurately. Timely and precise diagnosis is essential for effective treatment and improved patient outcomes. Traditional diagnostic methods for mTBI often…

Image and Video Processing · Electrical Eng. & Systems 2024-04-09 Hanem Ellethy , Shekhar S. Chandra , Viktor Vegh