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Related papers: Model-Based Reinforcement Learning for Sepsis Trea…

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Sepsis is a life-threatening condition affecting over 48.9 million people globally and causing 11 million deaths annually. Despite medical advancements, predicting sepsis remains a challenge due to non-specific symptoms and complex…

Machine Learning · Computer Science 2025-05-30 Dharambir Mahto , Prashant Yadav , Mahesh Banavar , Jim Keany , Alan T Joseph , Srinivas Kilambi

We develop and analyze explainable machine learning (ML) models for sepsis outcome prediction using a novel Electronic Health Record (EHR) dataset from 12,286 hospitalizations at a large emergency hospital in Romania. The dataset includes…

Machine Learning · Computer Science 2026-04-07 Andrei-Alexandru Bunea , Ovidiu Ghibea , Dan-Matei Popovici , Ion Daniel , Octavian Andronic

Segmentation of Multiple Sclerosis (MS) lesions is a challenging problem. Several deep-learning-based methods have been proposed in recent years. However, most methods tend to be static, that is, a single model trained on a large,…

Reinforcement learning (RL) has shown great success in estimating sequential treatment strategies which take into account patient heterogeneity. However, health-outcome information, which is used as the reward for reinforcement learning…

Machine Learning · Computer Science 2021-02-24 Aaron Sonabend-W , Nilanjana Laha , Ashwin N. Ananthakrishnan , Tianxi Cai , Rajarshi Mukherjee

Reinforcement learning (RL) is a powerful machine learning technique that enables an intelligent agent to learn an optimal policy that maximizes the cumulative rewards in sequential decision making. Most of methods in the existing…

Machine Learning · Statistics 2023-01-06 Chengchun Shi , Zhengling Qi , Jianing Wang , Fan Zhou

Many multi-genic systemic diseases such as neurological disorders, inflammatory diseases, and the majority of cancers do not have effective treatments yet. Reinforcement learning powered systems pharmacology is a potentially effective…

Biomolecules · Quantitative Biology 2022-02-25 Ryan K. Tan , Yang Liu , Lei Xie

Recent advances have demonstrated the effectiveness of Reinforcement Learning (RL) in improving the reasoning capabilities of Large Language Models (LLMs). However, existing works inevitably rely on high-quality instructions and verifiable…

Computation and Language · Computer Science 2026-01-27 Wenkai Fang , Shunyu Liu , Yang Zhou , Kongcheng Zhang , Tongya Zheng , Kaixuan Chen , Mingli Song , Dacheng Tao

As a paradigm for sequential decision making in unknown environments, reinforcement learning (RL) has received a flurry of attention in recent years. However, the explosion of model complexity in emerging applications and the presence of…

Machine Learning · Statistics 2025-07-22 Yuejie Chi , Yuxin Chen , Yuting Wei

Reinforcement learning (RL) has increasingly become a pivotal technique in the post-training of large language models (LLMs). The effective exploration of the output space is essential for the success of RL. We observe that for complex…

Machine Learning · Computer Science 2025-07-08 Shihan Dou , Muling Wu , Jingwen Xu , Rui Zheng , Tao Gui , Qi Zhang , Xuanjing Huang

Reinforcement Learning (RL) has proven a stunning ability to learn optimal policies from data without any prior knowledge on the process. The main drawback of RL is that it is typically very difficult to guarantee stability and safety. On…

Systems and Control · Electrical Eng. & Systems 2020-05-12 Mario Zanon , Vyacheslav Kungurtsev , Sébastien Gros

In this article, we aim to provide a literature review of different formulations and approaches to continual reinforcement learning (RL), also known as lifelong or non-stationary RL. We begin by discussing our perspective on why RL is a…

Machine Learning · Computer Science 2022-11-15 Khimya Khetarpal , Matthew Riemer , Irina Rish , Doina Precup

Reinforcement learning (RL) has achieved remarkable success in real-world decision-making across diverse domains, including gaming, robotics, online advertising, public health, and natural language processing. Despite these advances, a…

Applications · Statistics 2026-01-23 Asim H. Gazi , Yongyi Guo , Daiqi Gao , Ziping Xu , Kelly W. Zhang , Susan A. Murphy

Reinforcement Learning (RL) has been shown to be effective in many scenarios. However, it typically requires the exploration of a sufficiently large number of state-action pairs, some of which may be unsafe. Consequently, its application to…

Systems and Control · Electrical Eng. & Systems 2022-06-24 Yousef Emam , Gennaro Notomista , Paul Glotfelter , Zsolt Kira , Magnus Egerstedt

The success of Reinforcement Learning (RL) heavily relies on the ability to learn robust representations from the observations of the environment. In most cases, the representations learned purely by the reinforcement learning loss can…

Machine Learning · Computer Science 2024-02-12 Somjit Nath , Rushiv Arora , Samira Ebrahimi Kahou

Reinforcement learning (RL) has achieved phenomenal success in various domains. However, its data-driven nature also introduces new vulnerabilities that can be exploited by malicious opponents. Recent work shows that a well-trained RL agent…

Machine Learning · Computer Science 2024-03-08 Xiaolin Sun , Zizhan Zheng

Safe exploration remains a fundamental challenge in reinforcement learning (RL), limiting the deployment of RL agents in the real world. We propose Sampling-Based Safe Reinforcement Learning (SBSRL), a model-based RL algorithm that…

Machine Learning · Computer Science 2026-05-20 Luca Vignola , Bruce D. Lee , Manish Prajapat , Manuel Wendl , Melanie Zeilinger , Andreas Krause , Yarden As

Modern precision medicine aims to utilize real-world data to provide the best treatment for an individual patient. An individualized treatment rule (ITR) maps each patient's characteristics to a recommended treatment scheme that maximizes…

Applications · Statistics 2025-01-07 Andong Wang , Kelly Wentzlof , Johnny Rajala , Miontranese Green , Yunshu Zhang , Shu Yang

Sepsis is a leading cause of mortality and critical illness worldwide. While robust biomarkers for early diagnosis are still missing, recent work indicates that hyperspectral imaging (HSI) has the potential to overcome this bottleneck by…

Over the years, complex control approaches have been developed to control the motion of a bicycle. Reinforcement Learning (RL), a branch of machine learning, promises easy deployment of so-called agents. Deployed agents are increasingly…

Machine Learning · Computer Science 2024-07-25 Sebastian Weyrer , Peter Manzl , A. L. Schwab , Johannes Gerstmayr

Reinforcement Learning (RL) has emerged as a highly effective technique for addressing various scientific and applied problems. Despite its success, certain complex tasks remain challenging to be addressed solely with a single model and…

Machine Learning · Computer Science 2023-12-14 Yanjie Song , P. N. Suganthan , Witold Pedrycz , Junwei Ou , Yongming He , Yingwu Chen , Yutong Wu
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