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The heart beats due to the synchronized contraction of cardiomyocytes triggered by a periodic sequence of electrical signals called action potentials, which originate in the sinoatrial node and spread through the heart's electrical system.…

Pattern Formation and Solitons · Physics 2024-04-26 E. Angelaki , N. Lazarides , G. D. Barmparis , I. Kourakis , M. E. Marketou , G. P. Tsironis

Thanks to intrinsically short electronic relaxation on the ps time scale, III-V semiconductor unipolar devices are ideal candidates for ultrahigh-speed operation at mid-infrared frequencies. In this work, antenna-coupled, GaAs-based multi…

Instrumentation and Detectors · Physics 2024-06-13 Quyang Lin , Michael Hakl , Sylvie Lepillet , Hua Li , Jean-Francois Lampin , Emilien Peytavit , Stefano Barbieri

The recent introduction of coherent optical communications has created a compelling need for ultra-fast phase-sensitive measurement techniques operating at milliwatt peak power levels and in time scales ranging from sub-picoseconds to…

Electric pulses in biological cells (action potentials) have been reported to be accompanied by a propagating cell-surface deformation with a nano-scale amplitude. Typically, this cell surface is covered by external layers of polymer…

Biological Physics · Physics 2022-11-15 Matan Mussel , Christian Fillafer , Gal Ben-Porath , Matthias F. Schneider

Photoelectron momentum microscopy is an emerging powerful method for angle-resolved photoelectron spectroscopy (ARPES), especially in combination with imaging spin filters. These instruments record kx-ky images, typically exceeding a full…

Applied Physics · Physics 2021-02-03 G. Schoenhense , S. Babenkov , D. Vasilyev , H. -J. Elmers , K. Medjanik

Understanding how neurons coordinate their activity is a fundamental question in neuroscience, with implications for learning, memory, and neurological disorders. Calcium imaging has emerged as a powerful method to observe large-scale…

Methodology · Statistics 2026-03-03 Laura D'Angelo , Francesco Denti , Antonio Canale , Michele Guindani

Mid-infrared spectroscopy probes molecular vibrations to identify chemical species and functional groups. Therefore, mid-infrared hyperspectral imaging is one of the most powerful and promising candidates for chemical imaging using optical…

Optics · Physics 2023-07-06 Yue Zhao , Shota Kusama , Yuji Furutani , Wei-Hong Huang , Chih-Wei Luo , Takao Fuji

Dynamic scattering and imaging with coherent, ultrafast, extreme ultraviolet (EUV) light sources can resolve charge, phonon and spin processes on their intrinsic length and time scales. However, full field coherent diffraction imaging…

Coded aperture imaging transcends planar imaging with conventional collimators in efficiency and Field of View (FoV). We present experimental results for the detection of 141keV and 122keV {\gamma}-photons emitted by uniformly extended…

We introduce and experimentally demonstrate a method, where the two intrinsic time scales of a molecule, the slow nuclear motion and the fast electronic motion, are simultaneously measured in a photo-electron photo-ion coincidence…

X-ray photoelectron diffraction is a powerful tool for determining the structure of clean and adsorbate-covered surfaces. Extending the technique into the ultrafast time domain will open the door to studies as diverse as the direct…

Nonlinear interferometry with entangled photons allows for characterizing a sample without detecting the photons interacting with it. This method enables highly sensitive optical sensing in the wavelength regions where efficient detectors…

Optics · Physics 2025-08-11 Kazuki Hashimoto , Dmitri B. Horoshko , Maria V. Chekhova

We developed a new endogenous approach to reveal subcellular metabolic contrast in fresh ex vivo tissues taking advantage of the time dependence of the full field optical coherence tomography interferometric signals. This method reveals…

Medical Physics · Physics 2016-01-07 Clement Apelian , Fabrice Harms , Olivier Thouvenin , A. Claude Boccara

Hybrid pixel detectors have a well-established array of applications ranging from particle physics to life sciences. The small dimensions of Timepix3 as well as its relatively low energetic expenses make it an intriguing option additionally…

Instrumentation and Detectors · Physics 2025-09-10 Radu-Emanuel Mihai , Benedikt Bergmann , Petr Smolyanskiy

We demonstrate an alternative to Kelvin Probe Force Microscopy for imaging surface potential. The open-loop, single-pass technique applies a low-frequency AC voltage to the atomic force microscopy tip while driving the cantilever near its…

Mesoscale and Nanoscale Physics · Physics 2014-10-14 Riccardo Borgani , Daniel Forchheimer , Jonas Bergqvist , Per-Anders Thorén , Olle Inganäs , David B. Haviland

We present a novel way of wavefront sensing using a commercially available, continuous-wave time-of-flight camera with QVGA-resolution. This CMOS phase camera is capable of sensing externally modulated light sources with frequencies up to…

Instrumentation and Detectors · Physics 2021-08-18 Erik Muñiz , Varun Srivastava , Subham Vidyant , Stefan W. Ballmer

The electronic wavefunction is at the heart of physical phenomena, defining the frontiers of quantum materials research. While the amplitude of the electron wavefunction in crystals can be measured with state-of-the-art probes in…

Calcium imaging permits optical measurement of neural activity. Since intracellular calcium concentration is an indirect measurement of neural activity, computational tools are necessary to infer the true underlying spiking activity from…

Machine Learning · Statistics 2017-11-07 Artur Speiser , Jinyao Yan , Evan Archer , Lars Buesing , Srinivas C. Turaga , Jakob H. Macke

Single-molecule detection enables direct observation of individual biomolecular events, providing mechanistic insights into biological processes and offering a powerful tool for disease diagnostics. However, the fundamental scale mismatch…

Optics · Physics 2025-10-14 Guifeng Li , Chaoyang Gong

We introduce a imaging modality that works by transiently masking image-subregions during a single exposure of a CCD frame. By offsetting subregion exposure time, temporal information is embedded within each stored frame, allowing…

Quantitative Methods · Quantitative Biology 2016-09-08 Gil Bub , Matthias Tecza , Michiel Helmes , Peter Lee , Peter Kohl