Related papers: Assembling Omnitigs using Hidden-Order de Bruijn G…
Genome assembly is a fundamental problem in Bioinformatics, where for a given set of overlapping substrings of a genome, the aim is to reconstruct the source genome. The classical approaches to solving this problem use assembly graphs, such…
In this thesis, we address the problem of identifying and quantifying variants (alternative splicing and genomic polymorphism) in RNA-seq data when no reference genome is available, without assembling the full transcripts. Based on the…
Searching for other participants is one of the most important operations in a distributed system. We are interested in topologies in which it is possible to route a packet in a fixed number of hops until it arrives at its destination. Given…
Within biology, it is of interest to construct DNA complexes of a certain shape. These complexes can be represented through graph theory, using edges to model strands of DNA joined at junctions, represented by vertices. Because guided…
Aligning a sequence to a walk in a labeled graph is a problem of fundamental importance to Computational Biology. For finding a walk in an arbitrary graph with $|E|$ edges that exactly matches a pattern of length $m$, a lower bound based on…
Recently, Conte et al. generalized the longest-common prefix (LCP) array from strings to Wheeler DFAs, and they showed that it can be used to efficiently determine matching statistics on a Wheeler DFA [DCC 2023]. However, storing the LCP…
Drawing a graph in the plane with as few crossings as possible is one of the central problems in graph drawing and computational geometry. Another option is to remove the smallest number of vertices or edges such that the remaining graph…
A graph $G=(V,E)$ is word-representable if there exists a word $w$ over the alphabet $V$ such that letters $x$ and $y$ alternate in $w$ if and only if $xy\in E$. Word-representable graphs generalize several important classes of graphs such…
Discovering the underlying structures present in large real world graphs is a fundamental scientific problem. In this paper we show that a graph's clique tree can be used to extract a hyperedge replacement grammar. If we store an ordering…
An Eulerian circuit in a directed graph is one of the most fundamental Graph Theory notions. Detecting if a graph $G$ has a unique Eulerian circuit can be done in polynomial time via the BEST theorem by de Bruijn, van Aardenne-Ehrenfest,…
Graph embedding algorithms are used to efficiently represent (encode) a graph in a low-dimensional continuous vector space that preserves the most important properties of the graph. One aspect that is often overlooked is whether the graph…
Problems of the following kind have been the focus of much recent research in the realm of parameterized complexity: Given an input graph (digraph) on $n$ vertices and a positive integer parameter $k$, find if there exist $k$ edges (arcs)…
We initiate the study of computational problems on $k$-mers (strings of length $k$) in labeled graphs. As a starting point, we consider the problem of counting the number of distinct $k$-mers found on the walks of a graph. We establish that…
For positive integers $k,n$, a de Bruijn sequence $B(k,n)$ is a finite sequence of elements drawn from $k$ characters whose subwords of length $n$ are exactly the $k^n$ words of length $n$ on $k$ characters. This paper introduces the…
We present time-efficient distributed algorithms for decomposing graphs with large edge or vertex connectivity into multiple spanning or dominating trees, respectively. As their primary applications, these decompositions allow us to achieve…
An exact-match overlap graph of $n$ given strings of length $\ell$ is an edge-weighted graph in which each vertex is associated with a string and there is an edge $(x,y)$ of weight $\omega = \ell - |ov_{max}(x,y)|$ if and only if $\omega…
De Brujin graphs are widely used in bioinformatics for processing next-generation sequencing data. Due to a very large size of NGS datasets, it is essential to represent de Bruijn graphs compactly, and several approaches to this problem…
A cut-down de Bruijn sequence is a cyclic string of length $L$, where $1 \leq L \leq k^n$, such that every substring of length $n$ appears at most once. Etzion [Theor. Comp. Sci 44 (1986)] gives an algorithm to construct binary cut-down de…
Kautz and de Bruijn graphs have a high degree of connectivity which makes them ideal candidates for massively parallel computer network topologies. In order to realize a practical computer architecture based on these graphs, it is useful to…
Sequence assembly from short reads is an important problem in biology. It is known that solving the sequence assembly problem exactly on a bi-directed de Bruijn graph or a string graph is intractable. However finding a Shortest Double…