Related papers: Assembling Omnitigs using Hidden-Order de Bruijn G…
Motivation: Eugene Myers in his string graph paper (Myers, 2005) suggested that in a string graph or equivalently a unitig graph, any path spells a valid assembly. As a string/unitig graph also encodes every valid assembly of reads, such a…
Motivation: Intimately tied to assembly quality is the complexity of the de Bruijn graph built by the assembler. Thus, there have been many paradigms developed to decrease the complexity of the de Bruijn graph. One obvious combinatorial…
Partitioning a graph into balanced components is important for several applications. For multi-objective problems, it is useful not only to find one solution but also to enumerate all the solutions with good values of objectives. However,…
Orientable sequences of order n are infinite periodic sequences with symbols drawn from a finite alphabet of size k with the property that any particular subsequence of length n occurs at most once in a period in either direction. They were…
The decomposition of undirected graphs simplifies complex problems by breaking them into solvable subgraphs, following the philosophy of divide and conquer. This paper investigates the relationship between atom decomposition and the maximum…
We present kleuren, a novel assembly-free method to reconstruct phylogenetic trees using the Colored de Bruijn Graph. kleuren works by constructing the Colored de Bruijn Graph and then traversing it, finding bubble structures in the graph…
Motivation: Working with a large number of genomes simultaneously is of great interest in genetic population and comparative genomics research. Bubbles discovery in multi-genomes coloured de bruijn graph for de novo genome assembly is a…
Maximal clique enumeration is a fundamental graph mining task, but its utility is often limited by computational intractability and highly redundant output. To address these challenges, we introduce \emph{$\rho$-dense aggregators}, a novel…
Metagenomics research has accelerated the studies of microbial organisms, providing insights into the composition and potential functionality of various microbial communities. Metatranscriptomics (studies of the transcripts from a mixture…
Classic cycle-joining techniques have found widespread application in creating universal cycles for a diverse range of combinatorial objects, such as shorthand permutations, weak orders, orientable sequences, and various subsets of $k$-ary…
Recently, Marcus et al. (Bioinformatics 2014) proposed to use a compressed de Bruijn graph to describe the relationship between the genomes of many individuals/strains of the same or closely related species. They devised an $O(n \log g)$…
Graph analytics attract much attention from both research and industry communities. Due to the linear time complexity, the $k$-core decomposition is widely used in many real-world applications such as biology, social networks, community…
The focus of this work is to show how to combine Zech's logarithms and each of the cycle joining and cross-join pairing methods to construct binary de Bruijn sequences of any order. A basic implementation is supplied as a proof-of-concept.…
We consider the problem of sampling from the uniform distribution on the set of Eulerian orientations of subgraphs of the triangular lattice. Although it is known that this can be achieved in polynomial time for any graph, the algorithm…
Genome assembly is a fundamental problem in Bioinformatics, requiring to reconstruct a source genome from an assembly graph built from a set of reads (short strings sequenced from the genome). A notion of genome assembly solution is that of…
BioFabrics were introduced by Longabaugh in 2012 as a way to draw large graphs in a clear and uncluttered manner. The visual quality of BioFabrics crucially depends on the order of vertices and edges, which can be chosen independently.…
The graph structure is a commonly used data storage mode, and it turns out that the low-dimensional embedded representation of nodes in the graph is extremely useful in various typical tasks, such as node classification, link prediction ,…
(An updated version of this manuscript has been accepted to Scientific Reports in 2016, please refer to http://www.nature.com/articles/srep31900) The highly anticipated transition from next generation sequencing (NGS) to third generation…
Variation graphs, which represent genetic variation within a population, are replacing sequences as reference genomes. Path indexes are one of the most important tools for working with variation graphs. They generalize text indexes to…
De novo genome assembly is the process of stitching short DNA sequences to generate longer DNA sequences, without using any reference sequence for alignment. It enables high-throughput genome sequencing and thus accelerates the discovery of…