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The present paper deals with the problem of improving the efficiency of large scale turbulent flow simulations. The high-fidelity methods for modelling turbulent flows become available for a wider range of applications thanks to the…

Computational Physics · Physics 2018-04-10 Boris Krasnopolsky

Thrombosis in rotary blood pumps arises from complex flow conditions that remain difficult to translate into reliable and interpretable risk predictions using existing computational models. This limitation reflects an incomplete…

Machine Learning · Computer Science 2025-12-19 Christopher Blum , Michael Neidlin

Cerebrovascular diseases such as brain aneurysms are a primary cause of adult disability. The flow dynamics in brain arteries, both during periods of rest and increased activity, are known to be a major factor in the risk of aneurysm…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-04-30 Mohamed A. Itani , Ulf D. Schiller , Sebastian Schmieschek , James Hetherington , Miguel O. Bernabeu , Hoskote Chandrashekar , Fergus Robertson , Peter V. Coveney , Derek Groen

It is known that the maximum diameter for the rupture-risk assessment of the abdominal aortic aneurysm is a generally good method, but not sufficient. Alternative features obtained with computational modeling may provide additional useful…

Computational Engineering, Finance, and Science · Computer Science 2020-03-16 Shanlin Qin , Rongliang Chen , Bokai Wu , Jia Liu , Wen-Shin Shiu , Zhengzheng Yan , Xiao-Chuan Cai

To address existing challenges with intravascular mechanical thrombectomy devices, a novel ultrasound-enhanced aspiration approach is being developed to mechanically degrade clots using cavitation. This method employs standing waves within…

Medical Physics · Physics 2024-05-27 Li Gong , Alex R. Wright , Kullervo Hynynen , David E. Goertz

Many numerical studies of blood flow impose a rigid wall assumption due to the simplicity of its implementation compared to a full coupling to a solid mechanics model. In this paper, we present a localised method for incorporating the…

Fluid Dynamics · Physics 2021-08-20 J. W. S. McCullough , P. V. Coveney

Prosthetic heart valve interventions such as TAVR have surged over the past decade, but the associated complication of long-term, life-threatening thrombotic events continues to undermine patient outcomes. Thus, improving thrombogenic risk…

Computational Engineering, Finance, and Science · Computer Science 2024-06-19 Kyle Baylous , Brandon Kovarovic , Salwa Anam , Ryan Helbock , Marvin Slepian , Danny Bluestein

This paper presents a numerical method for the simulation of multiscale materials composed of an elastic matrix and slender active inclusions. The setting is motivated by the modeling of vascularized tissues and by problems arising in the…

Numerical Analysis · Mathematics 2025-08-19 Camilla Belponer , Alfonso Caiazzo , Luca Heltai

This paper provides a mathematical analysis of ultrafast ultrasound imaging. This newly emerging modality for biomedical imaging uses plane waves instead of focused waves in order to achieve very high frame rates. We derive the point spread…

Numerical Analysis · Mathematics 2017-01-09 Giovanni S. Alberti , Habib Ammari , Francisco Romero , Timothée Wintz

Aneurysms are localized bulges of arteries, and they can rupture with fatal consequences. Complex mechanobiological factors preclude in vivo testing to assess the rupture risk of an aneurysm, and size based criteria are often used in…

Medical Physics · Physics 2021-08-26 Masoud Hejazi , A. Srikantha Phani

A multiscale stochastic-deterministic coupling method is proposed to investigate the complex interactions between turbulent and rarefied gas flows within a unified framework. This method intermittently integrates the general synthetic…

Computational Physics · Physics 2025-03-14 Liyan Luo , Songyan Tian , Lei Wu

In this paper, a multiscale constitutive framework for one-dimensional blood flow modeling is presented and discussed. By analyzing the asymptotic limits of the proposed model, it is shown that different types of blood propagation phenomena…

Numerical Analysis · Mathematics 2023-12-13 Giulia Bertaglia , Lorenzo Pareschi

Numerous are the questionings raised by medicine interventionnelle, concerning the hold in charge of the pathologies of the arterial partition (aneurysm, dissection, coarctation, atherosclerosis).for it we made the modeling and the numeric…

Fluid Dynamics · Physics 2009-06-29 H . Alla , M. S. Gueblaoui , M. H. Bensaid

A simple coupled oscillator system with chemotaxis is introduced to study morphogenesis of cellular slime molds. The model successfuly explains the migration of pseudoplasmodium which has been experimentally predicted to be lead by cells…

adap-org · Physics 2009-10-30 Satoshi Sawai , Yoji Aizawa

Cerebral vasospasm, a prolonged constriction of cerebral arteries, is the first cause of morbidity and mortality for patients who survive hospitalisation after aneurysmal subarachnoid haemorrhage. The recent finding that stent-retrievers…

Computational Engineering, Finance, and Science · Computer Science 2024-09-02 Giulia Pederzani , Andrii Grytsan , Alfons G. Hoekstra , Anne M. Robertson , Paul N. Watton

We present a new optomechanical device where the motion of a micromechanical membrane couples to a microwave resonance of a three-dimensional superconducting cavity. With this architecture, we realize ultrastrong parametric coupling, where…

Quantum Physics · Physics 2020-01-09 G. A. Peterson , S. Kotler , F. Lecocq , K. Cicak , X. Y. Jin , R. W. Simmonds , J. Aumentado , J. D. Teufel

Active- and transfer-learning are applied to polymer flows for the multiscale discovery of effective constitutive approximations required in viscoelastic flow simulation. The result is macroscopic rheology directly connected to a…

Computational Physics · Physics 2021-02-03 Lifei Zhao , Zhen Li , Zhicheng Wang , Bruce Caswell , Jie Ouyang , George Em Karniadakis

This paper reports on the derivation and implementation of a shape optimization procedure for the minimization of hemolysis induction in biomedical devices. Hemolysis is a blood damaging phenomenon that may occur in mechanical…

Fluid Dynamics · Physics 2021-01-27 Georgios Bletsos , Niklas Kühl , Thomas Rung

Enodvascular coils treat intracranial aneurysms (IAs) by causing them to occlude by thrombosis. Ideally, coiled IAs eventually occlude in the long-term. However, 20.8% are found incompletely occluded at treatment follow-up. Computer…

Investigating blood flow in the cardiovascular system is crucial for assessing cardiovascular health. Computational approaches offer some non-invasive alternatives to measure blood flow dynamics. Numerical simulations based on traditional…

Numerical Analysis · Mathematics 2024-06-07 Han Zhang , Raymond Chan , Xue-Cheng Tai