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Computing the similarity between two DNA sequences is of vital importance in bioscience, yet it can be computationally expensive on classical hardware. For example, the edit distance with move operations (EDM), a DNA similarity measure of…

Quantum Physics · Physics 2025-12-03 Chenyu Shi , Gabriele Leoni , Mauro Petrillo , Antonio Puertas Gallardo , Hao Wang

DNA Data storage has recently attracted much attention due to its durable preservation and extremely high information density (bits per gram) properties. In this work, we propose a hybrid coding strategy comprising of generalized…

Information Theory · Computer Science 2021-12-20 Yixin Wang , Li Deng , Md. Noor-A-Rahim , Erry Gunawan , Yong L. Guan , Zhi P. Shi , Chueh L. Poh

DNA pattern matching is essential for many widely used bioinformatics applications. Disease diagnosis is one of these applications, since analyzing changes in DNA sequences can increase our understanding of possible genetic diseases. The…

Hardware Architecture · Computer Science 2022-06-01 Jinane Bazzi , Jana Sweidan , Mohammed E. Fouda , Rouwaida Kanj , Ahmed M. Eltawil

In this paper we introduce {\em weak ascent sequences}, a class of number sequences that properly contains ascent sequences. We show how these sequences uniquely encode each of the following objects: permutations avoiding a particular…

Combinatorics · Mathematics 2022-10-11 Beáta Bényi , Anders Claesson , Mark Dukes

Deep neural networks have been shown to learn and rely on spurious correlations present in the data that they are trained on. Reliance on such correlations can cause these networks to malfunction when deployed in the real world, where these…

Machine Learning · Computer Science 2025-05-20 Varun Mulchandani , Jung-Eun Kim

DNA storage is a promising archival data storage solution to today's big data problem. A DNA storage system encodes and stores digital data with synthetic DNA sequences and decodes DNA sequences back to digital data via sequencing. For…

Emerging Technologies · Computer Science 2024-03-25 Yixun Wei , Bingzhe Li , David Du

DNA data storage is rapidly emerging as a promising solution for long-term data archiving, largely due to its exceptional durability. However, the synthesis of DNA strands remains a significant bottleneck in terms of cost and speed. To…

Other Computer Science · Computer Science 2025-07-11 Parv Agarwal , Nimesh Pinnamaneni , Thomas Heinis

We consider DNA codes based on the nearest-neighbor (stem) similarity model which adequately reflects the "hybridization potential" of two DNA sequences. Our aim is to present a survey of bounds on the rate of DNA codes with respect to a…

Information Theory · Computer Science 2016-11-17 A. D'yachkov , A. Voronina , A. Macula , T. Renz , V. Rykov

Patterned nanomagnet arrays (PNAs) have been shown to exhibit a strong geometrically frustrated dipole interaction. Some PNAs have also shown emergent domain wall dynamics. Previous works have demonstrated methods to physically probe these…

Modeling genomic sequences faces two unsolved challenges: the information density varies widely across different regions, while there is no clearly defined minimum vocabulary unit. Relying on either four primitive bases or independently…

Genomics · Quantitative Biology 2025-11-20 Siyuan Li , Kai Yu , Anna Wang , Zicheng Liu , Chang Yu , Jingbo Zhou , Qirong Yang , Yucheng Guo , Xiaoming Zhang , Stan Z. Li

A novel processing-in-storage (PRinS) architecture based on Resistive CAM (ReCAM) is described and proposed for Smith-Waterman (S-W) sequence alignment. The ReCAM massively-parallel compare operation finds matching base-pairs in a fixed…

Emerging Technologies · Computer Science 2018-01-03 Roman Kaplan , Leonid Yavits , Ran Ginosar , Uri Weiser

Deep neural networks (DNNs) have been employed for designing wireless networks in many aspects, such as transceiver optimization, resource allocation, and information prediction. Existing works either use fully-connected DNN or the DNNs…

Machine Learning · Computer Science 2019-11-07 Jia Guo , Chenyang Yang

A new family of codes, called clustering-correcting codes, is presented in this paper. This family of codes is motivated by the special structure of data that is stored in DNA-based storage systems. The data stored in these systems has the…

Information Theory · Computer Science 2019-03-12 Tal Shinkar , Eitan Yaakobi , Andreas Lenz , Antonia Wachter-Zeh

Quantum maps are fundamental to quantum information theory and open quantum systems. Covariant or weakly symmetric quantum maps, in particular, play a key role in defining quantum evolutions that respect thermodynamics, establish free…

Quantum Physics · Physics 2025-02-10 Marco Cattaneo

DNA sequence encoding is fundamental to gene function prediction, protein synthesis, and diverse downstream biological tasks. Despite the substantial progress achieved by large-scale DNA sequence pretraining, existing studies have…

Machine Learning · Computer Science 2026-04-21 Zhijiang Tang , Jiaxin Qi , Yan Cui , Jinli Ou , Yuhua Zheng , Jianqiang Huang

Data compression plays an important role to deal with high volumes of DNA sequences in the field of Bioinformatics. Again data compression techniques directly affect the alignment of DNA sequences. So the time needed to decompress a…

Computational Engineering, Finance, and Science · Computer Science 2012-11-13 Subhankar Roy , Sunirmal Khatua , Sudipta Roy , Samir K. Bandyopadhyay

Constrained coding plays a key role in optimizing performance and mitigating errors in applications such as storage and communication, where specific constraints on codewords are required. While non-parametric constraints have been…

Information Theory · Computer Science 2025-05-05 Daniella Bar-Lev , Michael Shlizerman

The biggest challenge when using DNA as a storage medium is maintaining its stability. The relative occurrence of Guanine (G) and Cytosine (C) is essential for the longevity of DNA. In addition to that, reverse complementary base pairs…

Information Theory · Computer Science 2023-08-03 NallappaBhavithran G , Selvakumar R

The DNA storage channel is considered, in which a codeword is comprised of $M$ unordered DNA molecules. At reading time, $N$ molecules are sampled with replacement, and then each molecule is sequenced. A coded-index concatenated-coding…

Information Theory · Computer Science 2022-05-23 Nir Weinberger

High-throughput DNA sequencers are becoming indispensable in our understanding of diseases at molecular level, in marker-assisted selection in agriculture and in microbial genetics research. These sequencing instruments produce enormous…

Genomics · Quantitative Biology 2014-02-05 Saurabh Gupta , Sanjoy Chaudhury 'and' Binay Panda