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Despite super-resolution fluorescence blinking microscopes break the diffraction limit, the intense phototoxic illumination and long-term image sequences thus far still pose to major challenges in visualizing live-organisms. Here, we…
Dynamic full-field optical coherence tomography (D-FFOCT) has recently emerged as a label-free imaging tool, capable of resolving cell types and organelles within 3D live samples, whilst monitoring their activity at tens of milliseconds…
Optical phase-spaces represent fields of any spatial coherence, and are typically measured through phase-retrieval methods involving a computational inversion, interference, or a resolution-limiting lenslet array. Recently, a weak-values…
Dual-comb spectroscopy utilizes two sets of comb lines with slightly different comb-tooth-spacings, and optical spectral information is acquired by measuring the radio-frequency beat notes between the sets of comb lines. It holds the…
The simultaneous progress of integrated optical frequency comb (OFC) and radio frequency (RF) photonic signal processing technique have promoted the rapid development of real-time signal processing. Integrated optical frequency comb offer…
Confocal microscopy has long been a cornerstone technique for visualizing complex interactions and processes within cellular structures. However, achieving super-resolution imaging of multiple organelles and their interactions…
Ptychography is an enabling coherent diffraction imaging technique for both fundamental and applied sciences. Its applications in optical microscopy, however, fall short for its low imaging throughput and limited resolution. Here, we report…
A fluorescence correlation spectroscopy (FCS) system based on two independent measurement volumes is presented. The optical setup and data acquisition hardware are detailed, as well as a complete protocol to control the location, size and…
OCTOCAM is a multi-channel imager and spectrograph that has been proposed for the 10.4m GTC telescope. It will use dichroics to split the incoming light to produce simultaneous observations in 8 different bands, ranging from the ultraviolet…
We demonstrate numerical refocusing in coherent confocal laser scanning microscopy based on synthetic optical holography. This physics-based approach implements a computational propagation on the complex signal recovered in synthetic…
Optical frequency comb, as a spectrum made of discrete and equally spaced spectral lines, is a light source with essential applications in modern technology. Cavity optomechanical systems were found to be a feasible candidate for realizing…
Confocal microscopy is the backbone of cellular research labs across the world but unfortunately, the imaging is restricted to a single plane. Chromatic confocal microscopy offers the possibility to image multiple planes simultaneously thus…
We demonstrate photonic RF phase encoding based on an integrated micro-comb source. By assembling single-cycle Gaussian pulse replicas using a transversal filtering structure, phase encoded waveforms can be generated by programming the…
Rapid characterization of optical and vibrational spectra with high resolution can identify species in cluttered environments and is important for assays and early alerts. In this regard, dual-comb spectroscopy has emerged as a powerful…
Optical coherence tomography (OCT) has seen widespread success as an in vivo clinical diagnostic 3D imaging modality, impacting areas including ophthalmology, cardiology, and gastroenterology. Despite its many advantages, such as high…
Electro-optic frequency combs were employed to rapidly interrogate an optomechanical sensor, demonstrating spectral resolution substantially exceeding that possible with a mode-locked frequency comb. Frequency combs were generated using an…
In this article, we report an imaging method, termed Fourier ptychographic microscopy (FPM), which iteratively stitches together a number of variably illuminated, low-resolution intensity images in Fourier space to produce a wide-field,…
Frequency comb spectroscopy has significantly advanced molecular spectroscopy across scientific research and diverse applications. Among its key performance metrics especially for time-resolved studies, sensitivity and measurement speed are…
Optical frequency combs have emerged as a cornerstone for a wide range of areas, including spectroscopy, ranging, optical clocks, time and frequency transfer, waveform synthesis, and communications. However, quantum mechanical fluctuations…
A multichannel dual-comb spectroscopy (DCS) approach for high-resolution, broadband spectral measurements is presented, demonstrating its effectiveness in studying complex atomic systems. By implementing a photodetector array, we enhance…