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The methylation of DNA regulates gene expression. On cell division the methylation state of the DNA is typically inherited from parent to daughter cells. While the chemical bond between the methyl group and the DNA is very strong, changes…

Populations and Evolution · Quantitative Biology 2012-10-05 Sean P Stromberg

We propose a segmentation framework that uses deep neural networks and introduce two innovations. First, we describe a biophysics-based domain adaptation method. Second, we propose an automatic method to segment white and gray matter, and…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Amir Gholami , Shashank Subramanian , Varun Shenoy , Naveen Himthani , Xiangyu Yue , Sicheng Zhao , Peter Jin , George Biros , Kurt Keutzer

Alzheimer's disease (AD), a degenerative brain condition, can benefit from early prediction to slow its progression. As the disease progresses, patients typically undergo brain atrophy. Current prediction methods for Alzheimers disease…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Xin Honga , Jie Lin , Minghui Wang

Accurate phenotype prediction from RNA sequencing (RNA-seq) data is essential for diagnosis, biomarker discovery, and personalized medicine. Deep learning models have demonstrated strong potential to outperform classical machine learning…

Machine Learning · Computer Science 2026-03-10 Kevin Dradjat , Massinissa Hamidi , Blaise Hanczar

Although current face anti-spoofing methods achieve promising results under intra-dataset testing, they suffer from poor generalization to unseen attacks. Most existing works adopt domain adaptation (DA) or domain generalization (DG)…

Computer Vision and Pattern Recognition · Computer Science 2021-02-25 Jingjing Wang , Jingyi Zhang , Ying Bian , Youyi Cai , Chunmao Wang , Shiliang Pu

In recent years, there has been significant development in the analysis of medical data using machine learning. It is believed that the onset of Age-related Macular Degeneration (AMD) is associated with genetic polymorphisms. However,…

Computer Vision and Pattern Recognition · Computer Science 2024-09-18 Yoichi Furukawa , Satoshi Kamiya , Yoichi Sakurada , Kenji Kashiwagi , Kazuhiro Hotta

Identification of human genes involved in the aging process is critical due to the incidence of many diseases with age. A state-of-the-art approach for this purpose infers a weighted dynamic aging-specific subnetwork by mapping gene…

Molecular Networks · Quantitative Biology 2022-05-27 Qi Li , Khalique Newaz , Tijana Milenković

Gene expression (GE) data capture valuable condition-specific information ("condition" can mean a biological process, disease stage, age, patient, etc.) However, GE analyses ignore physical interactions between gene products, i.e.,…

Molecular Networks · Quantitative Biology 2020-04-16 Khalique Newaz , Tijana Milenkovic

Automatic age estimation from real-world and unconstrained face images is rapidly gaining importance. In our proposed work, a deep CNN model that was trained on a database for face recognition task is used to estimate the age information on…

Computer Vision and Pattern Recognition · Computer Science 2017-09-07 Zakariya Qawaqneh , Arafat Abu Mallouh , Buket D. Barkana

Federated learning enables collaborative model training across medical institutions without sharing raw data, but its performance is often limited by domain heterogeneity across clients. Existing approaches to address this challenge fall…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Chamani Shiranthika , Parvaneh Saeedi

Automated facial age estimation has diverse real-world applications in multimedia analysis, e.g., video surveillance, and human-computer interaction. However, due to the randomness and ambiguity of the aging process, age assessment is…

Computer Vision and Pattern Recognition · Computer Science 2022-10-20 Ziyuan Zhao , Peisheng Qian , Yubo Hou , Zeng Zeng

The need for training data can impede the adoption of novel imaging modalities for learning-based medical image analysis. Domain adaptation methods partially mitigate this problem by translating training data from a related source domain to…

Computer Vision and Pattern Recognition · Computer Science 2021-01-19 Eleni Chiou , Francesco Giganti , Shonit Punwani , Iasonas Kokkinos , Eleftheria Panagiotaki

Automatic prediction of age and gender from face images has drawn a lot of attention recently, due it is wide applications in various facial analysis problems. However, due to the large intra-class variation of face images (such as…

Computer Vision and Pattern Recognition · Computer Science 2020-12-09 Amirali Abdolrashidi , Mehdi Minaei , Elham Azimi , Shervin Minaee

Adapting machine learning models to medical time series across different domains remains a challenge due to complex temporal dependencies and dynamic distribution shifts. Current approaches often focus on isolated feature representations,…

Machine Learning · Computer Science 2025-09-23 YongKyung Oh , Alex Bui

For most diseases, building large databases of labeled genetic data is an expensive and time-demanding task. To address this, we introduce genetic Generative Adversarial Networks (gGAN), a semi-supervised approach based on an innovative GAN…

Machine Learning · Computer Science 2020-07-03 Caio Davi , Ulisses Braga-Neto

Motivation: DNA methylation is an intensely studied epigenetic mark, yet its functional role is incompletely understood. Attempts to quantitatively associate average DNA methylation to gene expression yield poor correlations outside of the…

Genomics · Quantitative Biology 2016-11-17 Chantriolnt-Andreas Kapourani , Guido Sanguinetti

The Convolutional Neural Network has amazed us with its usage on several applications. Age range estimation using CNN is emerging due to its application in myriad of areas which makes it a state-of-the-art area for research and improve the…

Computer Vision and Pattern Recognition · Computer Science 2021-04-20 Dipesh Gyawali , Prashanga Pokharel , Ashutosh Chauhan , Subodh Chandra Shakya

Background: Recent assays for individual-specific genome-wide DNA methylation profiles have enabled epigenome-wide association studies to identify specific CpG sites associated with a phenotype. Computational prediction of CpG site-specific…

Genomics · Quantitative Biology 2015-11-12 Weiwei Zhang , Tim D Spector , Panos Deloukas , Jordana T Bell , Barbara E Engelhardt

Population attributes are essential in health for understanding who the data represents and precision medicine efforts. Even within disease infection labels, patients can exhibit significant variability; "fever" may mean something different…

Machine Learning · Statistics 2018-11-28 Vishwali Mhasawade , Nabeel Abdur Rehman , Rumi Chunara

A classic approach for solving differential equations with neural networks builds upon neural forms, which employ the differential equation with a discretisation of the solution domain. Making use of neural forms for time-dependent…

Neural and Evolutionary Computing · Computer Science 2022-09-02 Toni Schneidereit , Michael Breuß