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Matched case-control studies are commonly employed in epidemiological research for their convenience and efficiency. Analysis of secondary outcomes can yield valuable insights into biological pathways and help identify genetic variants of…

Methodology · Statistics 2026-02-24 Shanshan Liu , Guoqing Diao

AI-enabled precision medicine promises a transformational improvement in healthcare outcomes by enabling data-driven personalized diagnosis, prognosis, and treatment. However, the well-known "curse of dimensionality" and the clustered…

Machine Learning · Computer Science 2023-05-19 Amanda M. Buch , Conor Liston , Logan Grosenick

Two successful approaches for the segmentation of biomedical images are (1) the selection of segment candidates from a merge-tree, and (2) the clustering of small superpixels by solving a Multi-Cut problem. In this paper, we introduce a…

Computer Vision and Pattern Recognition · Computer Science 2017-07-05 Jan Funke , Chong Zhang , Tobias Pietzsch , Stephan Saalfeld

Conformance checking is a process mining technique that allows verifying the conformance of process instances to a given model. Thus, this technique is predestined to be used in the medical context for the comparison of treatment cases with…

Artificial Intelligence · Computer Science 2022-09-21 Joscha Grüger , Tobias Geyer , Martin Kuhn , Stefan Braun , Ralph Bergmann

Clinical trials are essential for drug development but are extremely expensive and time-consuming to conduct. It is beneficial to study similar historical trials when designing a clinical trial. However, lengthy trial documents and lack of…

Computation and Language · Computer Science 2022-10-11 Zifeng Wang , Jimeng Sun

The comparison of different medical treatments from observational studies or across different clinical studies is often biased by confounding factors such as systematic differences in patient demographics or in the inclusion criteria for…

Methodology · Statistics 2025-05-15 Ekkehard Glimm , Lillian Yau

Accurate clinical coding is essential for healthcare documentation, billing, and decision-making. While prior work shows that off-the-shelf LLMs struggle with this task, evaluations based on exact match metrics often overlook errors where…

Computation and Language · Computer Science 2025-10-10 Zhangdie Yuan , Han-Chin Shing , Mitch Strong , Chaitanya Shivade

Clinicians may rely on medical coding systems such as International Classification of Diseases (ICD) to identify patients with diseases from Electronic Health Records (EHRs). However, due to the lack of detail and specificity as well as a…

Computation and Language · Computer Science 2022-05-19 Jingqing Zhang , Atri Sharma , Luis Bolanos , Tong Li , Ashwani Tanwar , Vibhor Gupta , Yike Guo

Deep learning approaches exhibit promising performances on various text tasks. However, they are still struggling on medical text classification since samples are often extremely imbalanced and scarce. Different from existing mainstream…

Computation and Language · Computer Science 2023-11-29 Jiahuan Yan , Haojun Gao , Zhang Kai , Weize Liu , Danny Chen , Jian Wu , Jintai Chen

We propose a new application of embedding techniques for problem retrieval in adaptive tutoring. The objective is to retrieve problems whose mathematical concepts are similar. There are two challenges: First, like sentences, problems…

Computers and Society · Computer Science 2020-03-25 Du Su , Ali Yekkehkhany , Yi Lu , Wenmiao Lu

International Classification of Diseases (ICD) is a set of classification codes for medical records. Automated ICD coding, which assigns unique International Classification of Diseases codes with each medical record, is widely used recently…

Artificial Intelligence · Computer Science 2022-12-12 Shi Wang , Daniel Tang , Luchen Zhang , Huilin Li , Ding Han

We propose a new coding scheme, called the delayed coding (DC) scheme, for channels with insertion, deletion, and substitution (IDS) errors. The proposed scheme employs delayed encoding and non-iterative detection and decoding strategies to…

Information Theory · Computer Science 2022-05-25 Ryo Shibata , Hiroyuki Yashima

We propose a novel and interpretable embedding method to represent the international statistical classification codes of diseases and related health problems (i.e., ICD codes). This method considers a self-attention mechanism within the…

Applications · Statistics 2019-06-14 Dixin Luo , Hongteng Xu , Lawrence Carin

The integration of multi-omics data has emerged as a promising approach for gaining comprehensive insights into complex diseases such as cancer. This paper proposes a novel approach to identify cancer subtypes through the integration of…

Machine Learning · Computer Science 2023-12-06 Mark Peelen , Leila Bagheriye , Johan Kwisthout

A classical problem in causal inference is that of matching, where treatment units need to be matched to control units based on covariate information. In this work, we propose a method that computes high quality almost-exact matches for…

Machine Learning · Statistics 2021-02-16 Tianyu Wang , Marco Morucci , M. Usaid Awan , Yameng Liu , Sudeepa Roy , Cynthia Rudin , Alexander Volfovsky

We propose a dynamic allocation procedure that increases power and efficiency when measuring an average treatment effect in sequential randomized trials. Subjects arrive iteratively and are either randomized or paired via a matching…

Methodology · Statistics 2013-05-23 Adam Kapelner , Abba Krieger

Cancer cell lines have frequently been used to link drug sensitivity and resistance with genomic profiles. To capture genomic complexity in cancer, the Cancer Genome Project (CGP) (Garnett et al., 2012) screened 639 human tumor cell lines…

Applications · Statistics 2017-02-09 Hongmei Liu , J. Sunil Rao

We present a new scientific document similarity model based on matching fine-grained aspects of texts. To train our model, we exploit a naturally-occurring source of supervision: sentences in the full-text of papers that cite multiple…

Computation and Language · Computer Science 2022-05-05 Sheshera Mysore , Arman Cohan , Tom Hope

Biological sequence comparison is a key step in inferring the relatedness of various organisms and the functional similarity of their components. Thanks to the Next Generation Sequencing efforts, an abundance of sequence data is now…

Machine Learning · Computer Science 2016-09-13 Dhananjay Kimothi , Akshay Soni , Pravesh Biyani , James M. Hogan

International Classification of Disease (ICD) coding procedure which refers to tagging medical notes with diagnosis codes has been shown to be effective and crucial to the billing system in medical sector. Currently, ICD codes are assigned…

Computation and Language · Computer Science 2021-04-22 Biplob Biswas , Thai-Hoang Pham , Ping Zhang