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Recent research is revealing how cognitive processes are supported by a complex interplay between the brain and the rest of the body, which can be investigated by the analysis of physiological features such as breathing rhythms, heart rate,…
In this paper we study a model of HCV with mitotic proliferation, a saturation infection rate and a discrete intracellular delay: the delay corresponds to the time between infection of a infected target hepatocytes and production of new HCV…
In a previous work we investigated the existence of Hopf degenerate bifurcation points for a differential delay equation modeling leukemia and we actually found Hopf points of codimension two for the considered problem. If around the…
Herewith we discuss a network model of the ferroptosis avascular and vascular tumor growth based on our previous proposed framework. Chiefly, ferroptosis should be viewed as a first order phase transition characterized by a supercritical…
We discuss a bifurcation scenario which creates periodic pulsating solutions in slow-fast delayed systems through a cascade of almost simultaneous Hopf bifurcations. This scenario has been previously associated with formation of pulses in a…
This study presents a mathematical model describing cloned hematopoiesis in chronic myeloid leukemia (CML) through a nonlinear system of differential equations. The primary objective is to understand the progression from healthy…
Dynamical properties of ultradiscrete Hopf bifurcation, similar to those of the standard Hopf bifurcation, are discussed by proposing a simple model of ultradiscrete equations with max-plus algebra. In ultradiscrete Hopf bifurcation, limit…
We investigate a diffusive, stage-structured epidemic model with the maturation delay and freely-moving delay. Choosing delays and diffusive rates as bifurcation parameters, the only possible way to destabilize the endemic equilibrium is…
A new detailed mathematical model for dynamics of immune response to hepatitis B is proposed, which takes into account contributions from innate and adaptive immune responses, as well as cytokines. Stability analysis of different steady…
We study a three-dimensional dynamical system in two slow variables and one fast variable. We analyze the tangency of the unstable manifold of an equilibrium point with "the" repelling slow manifold, in the presence of a stable periodic…
A new approach to the modular, complex systems analysis of nonlinear dynamics in cell cycling network transformations involved in carcinogenesis is proposed. Carcinogenesis is a complex process that involves dynamically inter-connected…
Accompanied by the development of microfabrication techniques, such as MEMS and micro-TAS, there has been increasing interests on the methodology to generate a desired motion on a micro object in a solution environment. It is well know that…
In this paper we analyse a dynamical system based on the so-called KCG (K\"all\'en, Crafoord, Ghil) conceptual climate model. This model describes an evolution of the globally averaged temperature and the average extent of the ice sheets.…
A novel flow state consisting of two oppositely travelling waves (TWs) with oscillating amplitudes has been found in the counterrotating Taylor-Couette system by full numerical simulations. This structure bifurcates out of axially standing…
Various biological phenomena, like cell differentiation and pattern formation in multicellular organisms, are explained using the bifurcation theory. Molecular network motifs like positive feedback and mutual repressor exhibit bifurcation…
We combine results available in the literature to prove that the torus emerging in a secondary Hopf bifurcation is normally hyperbolic. This result is then applied to establish sufficient conditions for the bifurcation of normally…
The generalized Hopf (Bautin) bifurcation is a well-studied codimension two bifurcation characterized by an equilibrium with a pair of simple purely imaginary eigenvalues as the only critical eigenvalues and the vanishing first Lyapunov…
Quantifying the stability of an equilibrium is central in the theory of dynamical systems as well as in engineering and control. A comprehensive picture must include the response to both small and large perturbations, leading to the…
Large observational clinical datasets become increasingly available for mining associations between various disease traits and administered therapy. These datasets can be considered as representations of the landscape of all possible…
We focus on various measures of the fluctuations of the sequence of intervals between beats of the human heart, and how such fluctuations can be used to assess the presence or likelihood of cardiovascular disease. We examine sixteen such…