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We propose a homotopy sampling procedure, loosely based on importance sampling. Starting from a known probability distribution, the homotopy procedure generates the unknown normalization of a target distribution. In the context of…
In solving real world systems for higher-codimension bifurcation problems, one often faces the difficulty in computing the normal form or the focus values associated with generalized Hopf bifurcation, and the normal form with unfolding for…
Sudden transitions in the state of a system are often undesirable in natural and human-made systems. Such transitions under fast variation of system parameters are called rate-induced tipping. We experimentally demonstrate rate-induced…
The low-density lipoprotein (LDL)/high-density lipoprotein (HDL)-cholesterol ratio has been shown a high correlation with the cardiovascular risk assessment. Is it possible to quantify the correlation mathematically? In this paper, we…
In this paper, we develop a dynamic model of HIV infection that incorporates latent hosts, cytotoxic T lymphocyte (CTL) immunity, saturated incidence rates, and two transmission mechanisms: virus-to-cell and cell-to-cell transmission. The…
The study of thrombosis is crucial to understand and develop new therapies for diseases like deep vein thrombosis, diabetes related strokes, pulmonary embolism etc. The last two decades have seen an exponential growth in studies related to…
In the human immune system, T-helper cells are able to differentiate into two lymphocyte subsets: Th1 and Th2. The intracellular signaling pathways of differentiation form a dynamic regulation network by secreting distinctive types of…
We present a detailed study of a scalar differential equation with threshold state-dependent delayed feedback. This equation arises as a simplification of a gene regulatory model. There are two monotone nonlinearities in the model: one…
In this work, we investigate the dynamical properties of a reaction-diffusion system arising from tumor-therapy modelling that features both nonlinear interactions and nonlocal delay. By applying the Lyapunov-Schmidt reduction, we establish…
Species diversity in ecosystems is often accompanied by the self-organisation of the population into fascinating spatio-temporal patterns. Here, we consider a two-dimensional three-species population model and study the spiralling patterns…
Atherosclerosis is one of the principle pathologies of cardiovascular disease with blood cholesterol a significant risk factor. The World Health Organisation estimates that approximately 2.5 million deaths occur annually due to the risk…
To understand the behavior of composite fluid particles such as nucleated cells and double-emulsions in flow, we study a finite-size particle encapsulated in a deforming droplet under shear flow as a model system. In addition to its…
We solve a simple model that supports a dynamic phase transition and show conditions for the existence of the transition. Using methods of large deviation theory we analytically compute the probability distribution for activity and entropy…
A data-driven model identification strategy is developed for dynamical systems near a supercritical Hopf bifurcation with nonautonomous inputs. This strategy draws on phase-amplitude reduction techniques, leveraging an analytical…
We present a bifurcation analysis of a normal form for travelling waves in one-dimensional excitable media. The normal form which has been recently proposed on phenomenological grounds is given in form of a differential delay equation. The…
In this paper we revisit the Mackey-Glass model for blood-forming process, which was proposed to describe the spontaneous fluctuations of the blood cell counts in normal individuals and the first stage of chronic myelocytic (or…
A one - parameter dynamical system is associated to the mathematical problem governing the membrane excitability of a ventricular cardiomyocyte, according to the Luo-Rudy I model. An algorithm used to construct the equilibrium curve is…
This paper presents a general framework to derive the weakly nonlinear stability near a Hopf bifurcation in a special class of multi-scale reaction-diffusion equations. The main focus is on how the linearity and nonlinearity of the fast…
We consider a heterogeneous, globally coupled population of excitatory quadratic integrate-and-fire neurons with excitability adaptation due to a metabolic feedback associated with ketogenic diet, a form of therapy for epilepsy. Bifurcation…
We study the effects of discrete, randomly distributed time delays on the dynamics of a coupled system of self-propelling particles. Bifurcation analysis on a mean field approximation of the system reveals that the system possesses patterns…