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Label noise in training data can significantly degrade a model's generalization performance for supervised learning tasks. Here we focus on the problem that noisy labels are primarily mislabeled samples, which tend to be concentrated near…

Machine Learning · Computer Science 2021-03-16 Hao-Chiang Shao , Hsin-Chieh Wang , Weng-Tai Su , Chia-Wen Lin

This paper presents a novel unsupervised segmentation method for 3D medical images. Convolutional neural networks (CNNs) have brought significant advances in image segmentation. However, most of the recent methods rely on supervised…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 Takayasu Moriya , Holger R. Roth , Shota Nakamura , Hirohisa Oda , Kai Nagara , Masahiro Oda , Kensaku Mori

This paper presents a comprehensive comparative analysis of prominent clustering algorithms K-means, DBSCAN, and Spectral Clustering on high-dimensional datasets. We introduce a novel evaluation framework that assesses clustering…

Machine Learning · Computer Science 2025-07-31 Vishnu Vardhan Baligodugula , Fathi Amsaad

A crucial step in single particle analysis (SPA) of cryogenic electron microscopy (Cryo-EM), 2D classification and alignment takes a collection of noisy particle images to infer orientations and group similar images together. Averaging…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Supawit Chockchowwat , Chandrajit L. Bajaj

The growing role of data-driven approaches to scientific discovery has unveiled a large class of models that involve latent transformations with a rigid algebraic constraint. Three-dimensional molecule reconstruction in Cryo-Electron…

Information Theory · Computer Science 2019-06-04 Amelia Perry , Jonathan Weed , Afonso S. Bandeira , Philippe Rigollet , Amit Singer

We present a novel clustering objective that learns a neural network classifier from scratch, given only unlabelled data samples. The model discovers clusters that accurately match semantic classes, achieving state-of-the-art results in…

Computer Vision and Pattern Recognition · Computer Science 2019-08-23 Xu Ji , João F. Henriques , Andrea Vedaldi

In complex visual recognition tasks it is typical to adopt multiple descriptors, that describe different aspects of the images, for obtaining an improved recognition performance. Descriptors that have diverse forms can be fused into a…

Computer Vision and Pattern Recognition · Computer Science 2015-06-15 Jayaraman J. Thiagarajan , Karthikeyan Natesan Ramamurthy , Andreas Spanias

Cellular processes are governed by macromolecular complexes inside the cell. Study of the native structures of macromolecular complexes has been extremely difficult due to lack of data. With recent breakthroughs in Cellular electron cryo…

Quantitative Methods · Quantitative Biology 2018-06-12 Chengqian Che , Ruogu Lin , Xiangrui Zeng , Karim Elmaaroufi , John Galeotti , Min Xu

Microstructure of materials is often characterized through image analysis to understand processing-structure-properties linkages. We propose a largely automated framework that integrates unsupervised and supervised learning methods to…

Applications · Statistics 2025-09-05 Kungang Zhang , Wei Chen , Wing K. Liu , L. Catherine Brinson , Daniel W. Apley

The immense amount of time series data produced by astronomical surveys has called for the use of machine learning algorithms to discover and classify several million celestial sources. In the case of variable stars, supervised learning…

Solar and Stellar Astrophysics · Physics 2022-10-12 R. Pantoja , M. Catelan , K. Pichara , P. Protopapas

Clustering is an essential problem in machine learning and data mining. One vital factor that impacts clustering performance is how to learn or design the data representation (or features). Fortunately, recent advances in deep learning can…

Machine Learning · Computer Science 2015-01-14 Gang Chen

A single-particle cryo-electron microscopy (cryo-EM) measurement, called a micrograph, consists of multiple two-dimensional tomographic projections of a three-dimensional (3-D) molecular structure at unknown locations, taken under unknown…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Shay Kreymer , Amit Singer , Tamir Bendory

Single particle imaging (SPI) at X-ray free electron lasers (XFELs) is particularly well suited to determine the 3D structure of particles in their native environment. For a successful reconstruction, diffraction patterns originating from a…

Data Analysis, Statistics and Probability · Physics 2021-12-17 Dameli Assalauova , Alexandr Ignatenko , Fabian Isensee , Sergey Bobkov , Darya Trofimova , Ivan A. Vartanyants

The use of fluorescent molecules to create long sequences of low-density, diffraction-limited images enables highly-precise molecule localization. However, this methodology requires lengthy imaging times, which limits the ability to view…

Image and Video Processing · Electrical Eng. & Systems 2024-03-26 Yair Ben Sahel , Yonina C. Eldar

Recently, a number of works have studied clustering strategies that combine classical clustering algorithms and deep learning methods. These approaches follow either a sequential way, where a deep representation is learned using a deep…

Machine Learning · Computer Science 2019-06-13 Severine Affeldt , Lazhar Labiod , Mohamed Nadif

Extended Vision techniques are ubiquitous in physics. However, the data cubes steaming from such analysis often pose a challenge in their interpretation, due to the intrinsic difficulty in discerning the relevant information from the…

Machine Learning · Computer Science 2024-07-16 Alessandro Bombini , Fernando García-Avello Bofías , Caterina Bracci , Michele Ginolfi , Chiara Ruberto

Cryo-Electron Microscopy (Cryo-EM) is a Nobel prize-winning technology for determining the 3D structure of particles at near-atomic resolution. A fundamental step in the recovering of the 3D single-particle structure is to align its 2D…

Image and Video Processing · Electrical Eng. & Systems 2021-01-12 Koby Bibas , Gili Weiss-Dicker , Dana Cohen , Noa Cahan , Hayit Greenspan

Medical image segmentation is a fundamental and critical step in many clinical approaches. Semi-supervised learning has been widely applied to medical image segmentation tasks since it alleviates the heavy burden of acquiring…

Image and Video Processing · Electrical Eng. & Systems 2022-08-29 Yichi Zhang , Rushi Jiao , Qingcheng Liao , Dongyang Li , Jicong Zhang

Manifold structure learning is often used to exploit geometric information among data in semi-supervised feature learning algorithms. In this paper, we find that local discriminative information is also of importance for semi-supervised…

Machine Learning · Computer Science 2016-07-12 Sen Wang , Feiping Nie , Xiaojun Chang , Xue Li , Quan Z. Sheng , Lina Yao

Unsupervised learning, and more specifically clustering, suffers from the need for expertise in the field to be of use. Researchers must make careful and informed decisions on which algorithm to use with which set of hyperparameters for a…

Machine Learning · Computer Science 2021-12-28 Antoine Zambelli
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