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Objective. Supervised learning paradigms are often limited by the amount of labeled data that is available. This phenomenon is particularly problematic in clinically-relevant data, such as electroencephalography (EEG), where labeling can be…

Machine Learning · Statistics 2020-08-03 Hubert Banville , Omar Chehab , Aapo Hyvärinen , Denis-Alexander Engemann , Alexandre Gramfort

The computational pipelines of single-particle cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) include an early particle-picking stage, in which a micrograph or tomogram is scanned to extract candidate particles,…

Signal Processing · Electrical Eng. & Systems 2026-04-14 Amnon Balanov , Alon Zabatani , Tamir Bendory

Determining the three-dimensional structure of proteins and protein complexes at atomic resolution is a fundamental task in structural biology. Over the last decade, remarkable progress has been made using "single particle" cryo-electron…

Numerical Analysis · Mathematics 2017-06-05 Alex Barnett , Leslie Greengard , Andras Pataki , Marina Spivak

We employ unsupervised machine learning to enhance the accuracy of our recently presented scaling method for wave confinement analysis [1]. We employ the standard k-means++ algorithm as well as our own model-based algorithm. We investigate…

This work presents an unsupervised deep discriminant analysis for clustering. The method is based on deep neural networks and aims to minimize the intra-cluster discrepancy and maximize the inter-cluster discrepancy in an unsupervised…

Machine Learning · Computer Science 2022-06-13 Jinyu Cai , Wenzhong Guo , Jicong Fan

Computer vision and machine learning tools offer an exciting new way for automatically analyzing and categorizing information from complex computer simulations. Here we design an ensemble machine learning framework that can independently…

Computer Vision and Pattern Recognition · Computer Science 2021-09-06 Maarja Bussov , Joonas Nättilä

Deep clustering against self-supervised learning is a very important and promising direction for unsupervised visual representation learning since it requires little domain knowledge to design pretext tasks. However, the key component,…

Computer Vision and Pattern Recognition · Computer Science 2020-08-21 Weijie Chen , Shiliang Pu , Di Xie , Shicai Yang , Yilu Guo , Luojun Lin

This research implements an advanced unsupervised clustering system for MNIST handwritten digits through two-phase deep autoencoder architecture. A deep neural autoencoder requires a training process during phase one to develop minimal yet…

Machine Learning · Computer Science 2025-06-13 Md. Faizul Islam Ansari

Unsupervised learning has gained prominence in the big data era, offering a means to extract valuable insights from unlabeled datasets. Deep clustering has emerged as an important unsupervised category, aiming to exploit the non-linear…

Machine Learning · Computer Science 2024-02-02 Georgios Vardakas , Ioannis Papakostas , Aristidis Likas

Cryo-electron microscopy (cryo-EM) is a powerful technique for determining high-resolution 3D biomolecular structures from imaging data. Its unique ability to capture structural variability has spurred the development of heterogeneous…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Minkyu Jeon , Rishwanth Raghu , Miro Astore , Geoffrey Woollard , Ryan Feathers , Alkin Kaz , Sonya M. Hanson , Pilar Cossio , Ellen D. Zhong

Unsupervised image classification, or image clustering, aims to group unlabeled images into semantically meaningful categories. Early methods integrated representation learning and clustering within an iterative framework. However, the rise…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Melih Baydar , Emre Akbas

This paper presents a multiple learner algorithm called the 'Three Ensemble Clustering 3EC' algorithm that classifies unlabeled data into quality clusters as a part of unsupervised learning. It offers the flexibility to explore the context…

Machine Learning · Computer Science 2021-07-09 Kundu , Debasish

Image clustering is a particularly challenging computer vision task, which aims to generate annotations without human supervision. Recent advances focus on the use of self-supervised learning strategies in image clustering, by first…

Computer Vision and Pattern Recognition · Computer Science 2024-09-30 Foivos Ntelemis , Yaochu Jin , Spencer A. Thomas

Cryo-electron microscopy (cryo-EM), the subject of the 2017 Nobel Prize in Chemistry, is a technology for determining the 3-D structure of macromolecules from many noisy 2-D projections of instances of these macromolecules, whose…

Computer Vision and Pattern Recognition · Computer Science 2020-04-22 Roy R. Lederman , Joakim Andén , Amit Singer

Clustering is a class of unsupervised learning methods that has been extensively applied and studied in computer vision. Little work has been done to adapt it to the end-to-end training of visual features on large scale datasets. In this…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 Mathilde Caron , Piotr Bojanowski , Armand Joulin , Matthijs Douze

Recent advances in semi-supervised learning methods rely on estimating the categories of unlabeled data using a model trained on the labeled data (pseudo-labeling) and using the unlabeled data for various consistency-based regularization.…

Machine Learning · Computer Science 2019-06-14 Chia-Wen Kuo , Chih-Yao Ma , Jia-Bin Huang , Zsolt Kira

Particle picking is a time-consuming step in single-particle analysis and often requires significant interventions from users, which has become a bottleneck for future automated electron cryo-microscopy (cryo-EM). Here we report a deep…

Quantitative Methods · Quantitative Biology 2016-05-09 Feng Wang , Huichao Gong , Gaochao liu , Meijing Li , Chuangye Yan , Tian Xia , Xueming Li , Jianyang Zeng

Clustering is an unsupervised machine learning methodology where unlabeled elements/objects are grouped together aiming to the construction of well-established clusters that their elements are classified according to their similarity. The…

Machine Learning · Statistics 2023-10-20 Dimitrios Saligkaras , Vasileios E. Papageorgiou

Clustering analysis is one of the most widely used statistical tools in many emerging areas such as microarray data analysis. For microarray and other high-dimensional data, the presence of many noise variables may mask underlying…

Machine Learning · Statistics 2008-03-26 Benhuai Xie , Wei Pan , Xiaotong Shen