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In cryo-electron microscopy (cryo-EM), a microscope generates a top view of a sample of randomly-oriented copies of a molecule. The problem of single particle reconstruction (SPR) from cryo-EM is to use the resulting set of noisy 2D…

Numerical Analysis · Mathematics 2014-09-16 Gene Katsevich , Alexander Katsevich , Amit Singer

Single-particle electron cryomicroscopy is an essential tool for high-resolution 3D reconstruction of proteins and other biological macromolecules. An important challenge in cryo-EM is the reconstruction of non-rigid molecules with parts…

Image and Video Processing · Electrical Eng. & Systems 2021-05-31 Amit Moscovich , Amit Halevi , Joakim Andén , Amit Singer

An unsupervised framework for hyperspectral image (HSI) clustering is proposed that incorporates masked deep representation learning with diffusion-based clustering, extending the Spatially-Regularized Superpixel-based Diffusion Learning…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Vutichart Buranasiri , James M. Murphy

The scarcity of labeled data often impedes the application of deep learning to the segmentation of medical images. Semi-supervised learning seeks to overcome this limitation by exploiting unlabeled examples in the learning process. In this…

Computer Vision and Pattern Recognition · Computer Science 2021-06-25 Jizong Peng , Marco Pedersoli , Christian Desrosiers

We propose a method for the unsupervised clustering of hyperspectral images based on spatially regularized spectral clustering with ultrametric path distances. The proposed method efficiently combines data density and geometry to…

Computer Vision and Pattern Recognition · Computer Science 2020-04-13 Shukun Zhang , James M. Murphy

This project aims to break down large pathology images into small tiles and then cluster those tiles into distinct groups without the knowledge of true labels, our analysis shows how difficult certain aspects of clustering tumorous and…

Image and Video Processing · Electrical Eng. & Systems 2020-12-29 Mostafa Ibrahim , Kevin Bryson

Multi-view clustering is an important research topic due to its capability to utilize complementary information from multiple views. However, there are few methods to consider the negative impact caused by certain views with unclear…

Machine Learning · Computer Science 2025-11-21 Jie Xu , Yazhou Ren , Huayi Tang , Zhimeng Yang , Lili Pan , Yang Yang , Xiaorong Pu , Philip S. Yu , Lifang He

Local discriminative representation is needed in many medical image analysis tasks such as identifying sub-types of lesion or segmenting detailed components of anatomical structures. However, the commonly applied supervised representation…

Computer Vision and Pattern Recognition · Computer Science 2021-03-25 Huai Chen , Jieyu Li , Renzhen Wang , Yijie Huang , Fanrui Meng , Deyu Meng , Qing Peng , Lisheng Wang

Electron cryomicroscopy (cryo-EM) is an imaging technique widely used in structural biology to determine the three-dimensional structure of biological molecules from noisy two-dimensional projections with unknown orientations. As the…

Numerical Analysis · Mathematics 2025-06-26 Bogdan Toader , Marcus A. Brubaker , Roy R. Lederman

We aim to improve segmentation through the use of machine learning tools during region agglomeration. We propose an active learning approach for performing hierarchical agglomerative segmentation from superpixels. Our method combines…

Computer Vision and Pattern Recognition · Computer Science 2015-03-13 Juan Nunez-Iglesias , Ryan Kennedy , Toufiq Parag , Jianbo Shi , Dmitri B. Chklovskii

Deep convolutional neural networks (CNNs) have demonstrated remarkable success in computer vision by supervisedly learning strong visual feature representations. However, training CNNs relies heavily on the availability of exhaustive…

Computer Vision and Pattern Recognition · Computer Science 2019-05-31 Jiabo Huang , Qi Dong , Shaogang Gong , Xiatian Zhu

Automated analyses of the outcome of a simulation have been an important part of atomistic modeling since the early days, addressing the need of linking the behavior of individual atoms and the collective properties that are usually the…

Chemical Physics · Physics 2019-05-22 Michele Ceriotti

Over the past decade, cryogenic electron microscopy (cryo-EM) has emerged as a primary method for determining near-native, near-atomic resolution 3D structures of biological macromolecules. In order to meet increasing demand for cryo-EM,…

Image and Video Processing · Electrical Eng. & Systems 2022-01-19 Paul T. Kim , Alex J. Noble , Anchi Cheng , Tristan Bepler

In this work we used unsupervised machine learning methods in order to find possible clustering structures in superconducting materials data sets. We used the SuperCon database, as well as our own data sets complied from literature, in…

Superconductivity · Physics 2022-07-13 B. Roter , N. Ninkovic , S. V. Dordevic

High-quality labeled datasets are essential for deep learning. Traditional manual annotation methods are not only costly and inefficient but also pose challenges in specialized domains where expert knowledge is needed. Self-supervised…

Computer Vision and Pattern Recognition · Computer Science 2023-11-16 Zhaocong liu , Fa Zhang , Lin Cheng , Huanxi Deng , Xiaoyan Yang , Zhenyu Zhang , Chichun Zhou

Unsupervised learning algorithms are beginning to achieve accuracies comparable to their supervised counterparts on benchmark computer vision tasks, but their utility for practical applications has not yet been demonstrated. In this work,…

Computer Vision and Pattern Recognition · Computer Science 2022-01-13 Jeremiah W. Johnson , Swathi Hari , Donald Hampton , Hyunju K. Connor , Amy Keesee

Manifold learning using deep neural networks been shown to be an effective tool for building sophisticated prior image models that can be applied to noise reduction in low-dose CT. We propose a new iterative CT reconstruction algorithm,…

Medical Physics · Physics 2020-10-20 Matthew Tivnan , J. Webster Stayman

In the field of materials science, microscopy is the first and often only accessible method for structural characterization. There is a growing interest in the development of machine learning methods that can automate the analysis and…

Materials Science · Physics 2022-09-28 Shizhao Lu , Brian Montz , Todd Emrick , Arthi Jayaraman

Given a union of non-linear manifolds, non-linear subspace clustering or manifold clustering aims to cluster data points based on manifold structures and also learn to parameterize each manifold as a linear subspace in a feature space. Deep…

Machine Learning · Computer Science 2022-01-26 Zengyi Li , Yubei Chen , Yann LeCun , Friedrich T. Sommer

The problem of unsupervised learning and segmentation of hyperspectral images is a significant challenge in remote sensing. The high dimensionality of hyperspectral data, presence of substantial noise, and overlap of classes all contribute…

Computer Vision and Pattern Recognition · Computer Science 2018-10-17 James M. Murphy , Mauro Maggioni
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