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Background. Dengue outbreaks are a major public health issue, with Brazil reporting 71% of global cases in 2024. Purpose. This study aims to describe the profile of severe dengue patients admitted to Brazilian Intensive Care units (ICUs)…
Three drugs, Ibuprofen, Aspirin and Erythromycin, are encapsulated in spherical Pluronic F127 micelles. The shapes and the size distributions of the micelles in dilute, aqueous solutions, with and without drugs, are ascertained using cryo-…
In this paper, we use a Bayesian method to estimate the effective reproduction number (R(t)), in the context of monitoring the time evolution of the COVID-19 pandemic in Brazil at different geographic levels. The focus of this study is to…
We report the results of our study of approved drugs as potential treatments for COVID 19, based on the application of various bioinformatics predictive methods. The drugs studied include chloroquine, ivermectin, remdesivir, sofosbuvir,…
This data paper describes and publicly releases this dataset (v1.0.0), published on Zenodo under DOI 10.5281/zenodo.18189192. Motivated by the need to increase the temporal granularity of originally monthly data to enable more effective…
We address a biophysical network dynamical model to study how the modulation of dopamine (DA) activity and related N-methyl-d-aspartate (NMDA) glutamate receptor activity as well as the emerging Pre-Frontal Cortex (PFC) functional…
Alzheimer disease (AD) is considered one of the leading causes of death in the United States, and there is no effective cure for it. Understanding the neuropathological mechanisms underlying AD is essential for identifying early, reliable…
The scintillation anisotropy effect for proton recoil events has been investigated in five pure organic crystalline materials: anthracene, trans-stilbene, p-terphenyl, bibenzyl, and diphenylacetylene. These measurements include…
Aedes albopictus has been newly recorded in Agdal district at Rabat in Morocco. The establishment of this invasive mosquito could affect the public health by causing serious epidemics despite of its high nuisance in urban and sub-urban…
Monkeypox is a viral disease belonging to the smallpox family. Although it has milder symptoms than smallpox in humans, it has become a global threat in recent years, especially in African countries. Initially, incidental immunity against…
Several studies suggest that cyclooxygenase (COX)-2 plays a pivotal role in the progression of ischaemic brain damage. In the present study, we investigated the effects of selective inhibition of COX-2 with nimesulide (12 mg/kg) and…
In recent years, the US has experienced an opioid epidemic with an unprecedented number of drugs overdose deaths. Research finds such overdose deaths are linked to neighborhood-level traits, thus providing opportunity to identify effective…
Congenital cognitive dysfunctions are frequently due to deficits in molecular pathways that underlie synaptic plasticity. For example, Rubinstein-Taybi syndrome (RTS) is due to a mutation in cbp, encoding the histone acetyltransferase…
Background: Community-acquired pneumonia (CAP) is an acute disease condition with a high risk of rapid deteriorations. We analysed the influence of genetics on cytokine regulation to obtain a better understanding of patient's heterogeneity.…
Myopia is a common visual disorder that affects millions of people worldwide and its prevalence has been increasing in recent years. Environmental factors, such as reading time, viewing distance, and ambient lighting, have been identified…
In this work we propose a new biophysical computational model of brain regions relevant to Parkinson's Disease based on local field potential data collected from the brain of marmoset monkeys. Parkinson's disease is a neurodegenerative…
More than half of the world's population is exposed to the risk of mosquito-borne diseases, which leads to millions of cases and hundreds of thousands of deaths every year. Analyzing this type of data is often complex and poses several…
Reports from the Health Department in the Philippines show that cases of Human Immunodeficiency Virus (HIV) are increasing despite management and control efforts by the government. Worldwide, the Philippines has one of the fastest growing…
Diabetic-induced peripheral neuropathy (DPN) is a diabetic late complication. The molecular mechanisms underlying the pathophysiology of nerve damage & sensory loss remain largely unclear. Recently, alterations in metabolic flux have gained…
Non-degradable fluorophores that accumulate as Lipofuscin in retinal pigment epithelium (RPE) cells has been a major source of intrinsic biomarker for quantifying the progression of several diseases, including age-related macular…