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The main target of this paper is to present an efficient method to solve a nonlinear free boundary mathematical model of prostate tumor. This model consists of two parabolics, one elliptic and one ordinary differential equations that are…

Numerical Analysis · Mathematics 2022-03-31 Farzaneh Nasresfahani , M. R. Eslahchi

The method of matched asymptotic expansions is used to study the canonical problem of steady laminar flow through a narrow two-dimensional channel blocked by a tight-fitting finite-length highly permeable porous obstacle. We investigate the…

Fluid Dynamics · Physics 2016-12-05 Mohit P. Dalwadi , S. Jonathan Chapman , Sarah L. Waters , James M. Oliver

The two-dimensional free-boundary problem describing steady gravity waves with vorticity on water of finite depth is considered. Bounds for stream functions as well as free-surface profiles and the total head are obtained under the…

Mathematical Physics · Physics 2016-11-29 Vladimir Kozlov , Nikolay Kuznetsov

We consider an optimal control problem for a diffuse interface model of tumor growth. The state equations couples a Cahn-Hilliard equation and a reaction-diffusion equation, which models the growth of a tumor in the presence of a nutrient…

Optimization and Control · Mathematics 2016-08-02 Harald Garcke , Kei-Fong Lam , Elisabetta Rocca

We study a porous medium equation that models tissue growth in a heterogeneous environment. We show that, in the incompressible limit, solutions converge to those of a weak form of a Hele-Shaw type free boundary problem. To obtain enough…

Analysis of PDEs · Mathematics 2025-12-11 Anthony Sulak , Olga Turanova

The present paper is devoted to the joint motion of two immiscible incompressible liquids in porous media. The liquids have different densities and initially separated by a surface of strong discontinuity (free boundary). We discuss the…

Differential Geometry · Mathematics 2011-10-10 O. V. Galtsev , A. M. Meirmanov

In this paper a macroscopic model of tumor cord growth is developed, relying on the mathematical theory of deformable porous media. Tumor is modeled as a saturated mixture of proliferating cells, extracellular fluid and extracellular…

Mathematical Physics · Physics 2010-11-09 Andrea Tosin

Tumor growth has a number of features in common with a physical process known as molecular beam epitaxy. Both growth processes are characterized by the constraint of growth development to the body border, and surface diffusion of…

Quantitative Methods · Quantitative Biology 2009-11-13 Carlos Escudero

Mechanical models of tumor growth based on a porous medium approach have been attracting a lot of interest both analytically and numerically. In this paper, we study the stability properties of a finite difference scheme for a model where…

Numerical Analysis · Mathematics 2021-05-24 Noemi David , Xinran Ruan

Strong experimental evidence has indicated that tumor growth belongs to the molecular beam epitaxy universality class. This type of growth is characterized by the constraint of cell proliferation to the tumor border, and surface diffusion…

Quantitative Methods · Quantitative Biology 2009-11-13 Carlos Escudero

Geometric flows related to shape optimization problems of Bernoulli type are investigated. The evolution law is the sum of a curvature term and a nonlocal term of Hele-Shaw type. We introduce generalized set solutions, the definition of…

Analysis of PDEs · Mathematics 2010-02-15 Pierre Cardaliaguet , Olivier Ley

We consider a free boundary model of epithelial cell migration with logistic growth and nonlinear diffusion induced by mechanical interactions. Using numerical simulations, phase plane and perturbation analysis, we find and analyse…

Pattern Formation and Solitons · Physics 2020-10-05 Ryan J Murphy , Pascal R Buenzli , Ruth E Baker , Matthew J Simpson

We investigate the large time behavior of an agent based model describing tumor growth. The microscopic model combines short-range repulsion and cell division. As the number of cells increases exponentially in time, the microscopic model is…

Soft Condensed Matter · Physics 2017-01-04 Sebastien Motsch , Diane Peurichard

We study the behavior of solutions to the first-order mean field games system with a local coupling, when the initial density is a compactly supported function on the real line. Our results show that the solution is smooth in regions where…

Analysis of PDEs · Mathematics 2023-08-02 Pierre Cardaliaguet , Sebastian Munoz , Alessio Porretta

In this paper, we study a phase field model for a tumor growth model of Cahn--Hilliard type in which the often assumed parabolic relaxation of the chemical potential is replaced by a hyperbolic one. We show that the resulting…

Analysis of PDEs · Mathematics 2026-02-16 Pierluigi Colli , Elisabetta Rocca , Jürgen Sprekels

A mutualist model with nonlocal diffusions and a free boundary is first considered. We prove that this problem has a unique solution defined $t\ge0$, and its dynamics are governed by a spreading-vanishing dichotomy. Some criteria for…

Analysis of PDEs · Mathematics 2021-10-28 Lei Li , Mingxin Wang

In this paper, we study a distributed optimal control problem for a diffuse interface model for tumor growth. The model consists of a Cahn-Hilliard type equation for the phase field variable coupled to a reaction diffusion equation for the…

Optimization and Control · Mathematics 2021-10-12 Matthias Ebenbeck , Patrik Knopf

We study capillary-gravity surface waves for fluid flows governed by Darcy's law. This includes flows in vertical Hele-Shaw cells and in porous media (the one-phase Muskat problem) with finite or infinite depth. The free boundary is acted…

Analysis of PDEs · Mathematics 2026-02-20 Huy Q. Nguyen

In this paper, we investigate the speed of convergence and higher-order asymptotics of solutions to the porous medium equation posed in $\mathbf{R}^N$. Applying a nonlinear change of variables, we rewrite the equation as a diffusion on a…

Analysis of PDEs · Mathematics 2015-05-26 Christian Seis

We study the Cahn-Hilliard-Biot model with respect to its mathematical well-posedness. The system models flow through deformable porous media in which the solid material has two phases with distinct material properties. The two phases of…

Analysis of PDEs · Mathematics 2024-10-04 Marvin Fritz