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In this work we analyse a PDE-ODE problem modelling the evolution of a Glioblastoma, which includes an anisotropic nonlinear diffusion term with a diffusion velocity increasing with respect to vasculature. First, we prove the existence of…

Analysis of PDEs · Mathematics 2021-09-21 A. Fernández-Romero , F. Guillén-González , A. Suárez

We consider the Cauchy problem of the porous medium type reaction-diffusion equation \begin{equation*} \partial_t\rho=\Delta\rho^m+\rho g(\rho),\quad (x,t)\in \mathbb{R}^n\times \mathbb{R}_+,\quad n\geq2,\quad m>1, \end{equation*} where $g$…

Analysis of PDEs · Mathematics 2024-08-30 Qingyou He

This paper investigates the connection between the chemotaxis--Navier--Stokes system with porous medium type nonlinear diffusion and the Hele--Shaw problem in $\mathbb{R}^d$ ($d\geq2$). First, we prove the global-in-time existence of weak…

Analysis of PDEs · Mathematics 2025-06-16 Qingyou He , Ling-Yun Shou , Leyun Wu

An asymptotic analysis for a system with equation and dynamic boundary condition of Cahn-Hilliard type is carried out as the coefficient of the surface diffusion acting on the phase variable tends to 0, thus obtaining a forward-backward…

Analysis of PDEs · Mathematics 2021-06-03 Pierluigi Colli , Takeshi Fukao , Luca Scarpa

We develop a numerical method for solving a free boundary problem which describes shape relaxation, by surface tension, of a long and thin bubble of an inviscid fluid trapped inside a viscous fluid in a Hele-Shaw cell. The method of…

Computational Physics · Physics 2007-05-23 Arkady Vilenkin , Baruch Meerson

We consider the free boundary problem for two layers of immiscible, viscous, incompressible fluid in a uniform gravitational field, lying above a general rigid bottom in a three-dimensional horizontally periodic setting. We establish the…

Analysis of PDEs · Mathematics 2015-10-07 Yanjin Wang , Ian Tice , Chanwoo Kim

We establish the global well-posedness of the free boundary problem of the viscous pressureless and almost pressureless heat conductive flows in one space dimension. In both cases, arbitrarily large but smooth initial data is considered,…

Analysis of PDEs · Mathematics 2025-04-08 Xin Liu

We consider the problem of the long time dynamics for a diffuse interface model for tumor growth. The model describes the growth of a tumor surrounded by host tissues in the presence of a nutrient and consists in a Cahn-Hilliard-type…

Analysis of PDEs · Mathematics 2018-10-30 Alain Miranville , Elisabetta Rocca , Giulio Schimperna

We study the existence of weak solutions to a mixture model for tumour growth that consists of a Cahn--Hilliard--Darcy system coupled with an elliptic reaction-diffusion equation. The Darcy law gives rise to an elliptic equation for the…

Analysis of PDEs · Mathematics 2018-03-26 Harald Garcke , Kei Fong Lam

In this paper, we use the Bayesian inversion approach to study the data assimilation problem for a family of tumor growth models described by porous-medium type equations. The models contain uncertain parameters and are indexed by a…

Numerical Analysis · Mathematics 2024-02-14 Yu Feng , Liu Liu , Zhennan Zhou

The transport of single-phase fluid mixtures in porous media is described by cross-diffusion equations for the mass densities. The equations are obtained in a thermodynamic consistent way from mass balance, Darcy's law, and the van der…

Analysis of PDEs · Mathematics 2016-12-14 Ansgar Jüngel , Jiří Mikyška , Nicola Zamponi

In this paper, we characterize a degenerate PDE as the gradient flow in the space of nonnegative measures endowed with an optimal transport-growth metric. The PDE of concern, of Hele-Shaw type, was introduced by Perthame et. al. as a…

Analysis of PDEs · Mathematics 2017-12-19 Lénaïc Chizat , Simone Di Marino

In this paper, we investigate a class of tumor growth models governed by porous medium-type equations with uncertainties arisen from the growth function, initial condition, tumor support radius or other parameters in the model. We develop a…

Numerical Analysis · Mathematics 2025-06-24 Ning Jiang , Liu Liu , Huimin Yu

In this paper we study nonlocal-to-local asymptotics for a tumor-growth model coupling a viscous Cahn-Hilliard equation describing the tumor proportion with a reaction-diffusion equation for the nutrient phase parameter. First, we prove…

Analysis of PDEs · Mathematics 2023-11-20 Elisa Davoli , Elisabetta Rocca , Luca Scarpa , Lara Trussardi

We consider a one--spatial dimensional tumour growth model [2, 3, 4] that consists of three dependent variables of space and time: volume fraction of tumour cells, velocity of tumour cells, and nutrient concentration. The model variables…

Numerical Analysis · Mathematics 2020-07-01 Jerome Droniou , Neela Nataraj , Gopikrishnan Chirappurathu Remesan

Cancer is a disease of cellular regulation, often initiated by genetic mutation within cells, and leading to a heterogeneous cell population within tissues. In the competition for nutrients and growth space within the tumors the phenotype…

Populations and Evolution · Quantitative Biology 2017-08-08 András Szabó , Roeland M. H. Merks

We analyze long-time behavior of solutions to a class of problems related to very fast and singular diffusion porous medium equations having nonhomogeneous in space and time source terms with zero mean. In dimensions two and three, we…

Analysis of PDEs · Mathematics 2022-10-24 Georgy Kitavtsev , Roman M. Taranets

We study a non-local variant of a diffuse interface model proposed by Hawkins--Darrud et al. (2012) for tumour growth in the presence of a chemical species acting as nutrient. The system consists of a Cahn--Hilliard equation coupled to a…

Analysis of PDEs · Mathematics 2017-03-13 Sergio Frigeri , Kei Fong Lam , Elisabetta Rocca

We are concerned with a model describing the motion of two compressible, immiscible fluids with density-dependent viscosity in the whole $\mathbb R^3$. The phases of the flow may have different pressure and viscosity laws and are separated…

Analysis of PDEs · Mathematics 2025-10-14 Marcel Zodji

In this work, we present a phase-field model for tumour growth, where a diffuse interface separates a tumour from the surrounding host tissue. In our model, we consider transport processes by an internal, non-solenoidal velocity field. We…

Numerical Analysis · Mathematics 2024-06-21 Harald Garcke , Dennis Trautwein